- Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury
[作者:Duffy, P; Wang, XX; Siegel, CS; Tu, N; Henkemeyer, M; Cafferty, WBJ; Strittmatter, SM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5063-5068 , 文章类型: Article,,卷期:2012年109-13]
- Recovery of neurological function after traumatic injury of the adult mammalian central nervous system is limited by lack of axonal growth. Myelin-derived inhibitors contribute to axonal growth restriction, with ephrinB3...
- An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
[作者:Guareschi, S; Cova, E; Cereda, C; Ceroni, M; Donetti, E; Bosco, DA; Trotti, D; Pasinelli, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5074-5079 , 文章类型: Article,,卷期:2012年109-13]
- Recent studies suggest that Cu/Zn superoxide dismutase (SOD1) could be pathogenic in both familial and sporadic amyotrophic lateral sclerosis (ALS) through either inheritable or nonheritable modifications. The presence o...
- Rabbits are not resistant to prion infection
[作者:Chianini, F; Fernandez-Borges, N; Vidal, E; Gibbard, L; Pintadoe, B; de Castro, J; Priola, SA; Hamilton, S; Eaton, SL; Finlayson, J; Pang, Y; Steele, P; Reid, HW; Dagleish, MP; Castilla, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5080-5085 , 文章类型: Article,,卷期:2012年109-13]
- The ability of prions to infect some species and not others is determined by the transmission barrier. This unexplained phenomenon has led to the belief that certain species were not susceptible to transmissible spongifo...
- Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
[作者:Bershtein, S; Wu, WM; Shakhnovich, EI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4857-4862 , 文章类型: Article,,卷期:2012年109-13]
- Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of pro...
- Cellular solid-state nuclear magnetic resonance spectroscopy
[作者:Renault, M; Tommassen-van Boxtel, R; Bos, MP; Post, JA; Tommassen, J; Baldus, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4863-4868 , 文章类型: Article,,卷期:2012年109-13]
- Decrypting the structure, function, and molecular interactions of complex molecular machines in their cellular context and at atomic resolution is of prime importance for understanding fundamental physiological processes...
- Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion
[作者:Bakker, GJ; Eich, C; Torreno-Pina, JA; Diez-Ahedo, R; Perez-Samper, G; van Zanten, TS; Figdor, CG; Cambi, A; Garcia-Parajo, MF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4869-4874 , 文章类型: Article,,卷期:2012年109-13]
- Integrins are cell membrane adhesion receptors involved in morphogenesis, immunity, tissue healing, and metastasis. A central, yet unresolved question regarding the function of integrins is how these receptors regulate b...
- Contextual encoding by ensembles of medial prefrontal cortex neurons
[作者:Hyman, JM; Ma, LY; Balaguer-Ballester, E; Durstewitz, D; Seamans, JK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5086-5091 , 文章类型: Article,,卷期:2012年109-13]
- Contextual representations serve to guide many aspects of behavior and influence the way stimuli or actions are encoded and interpreted. The medial prefrontal cortex (mPFC), including the anterior cingulate subregion, ha...
- Nanoparticle delivery in infant lungs
[作者:Semmler-Behnke, M; Kreyling, WG; Schulz, H; Takenaka, S; Butler, JP; Henry, FS; Tsuda, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5092-5097 , 文章类型: Article,,卷期:2012年109-13]
- The lung surface is an ideal pathway to the bloodstream for nanoparticle-based drug delivery. Thus far, research has focused on the lungs of adults, and little is known about nanoparticle behavior in the immature lungs o...
- Plasmodesmata formation and cell-to-cell transport are reduced in decreased size exclusion limit 1 during embryogenesis in Arabidopsis
[作者:Xu, M; Cho, EN; Burch-Smith, TM; Zambryski, PC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5098-5103 , 文章类型: Article,,卷期:2012年109-13]
- In plants, plasmodesmata (PD) serve as channels for micromolecular and macromolecular cell-to-cell transport. Based on structure, PD in immature tissues are classified into two types, simple and branched (X-and Y-shaped)...
- Multiple organellar RNA editing factor (MORF) family proteins are required for RNA editing in mitochondria and plastids of plants
[作者:Takenaka, M; Zehrmann, A; Verbitskiy, D; Kugelmann, M; Hartel, B; Brennicke, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5104-5109 , 文章类型: Article,,卷期:2012年109-13]
- RNA editing in plastids and mitochondria of flowering plants changes hundreds of selected cytidines to uridines, mostly in coding regions of mRNAs. Specific sequences around the editing sites are presumably recognized by...
- Initiation factor 2, tRNA, and 50S subunits cooperatively stabilize mRNAs on the ribosome during initiation
[作者:Masuda, T; Petrov, AN; Iizuka, R; Funatsu, T; Puglisi, JD; Uemura, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4881-4885 , 文章类型: Article,,卷期:2012年109-13]
- Initiation factor 2 (IF2) is a key factor in initiation of bacterial protein synthesis. It recruits initiator tRNA to the small ribosomal subunit and facilitates joining of the large ribosomal subunit. Using reconstitute...
- Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis
[作者:Livshits, G; Kobielak, A; Fuchs, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4886-4891 , 文章类型: Article,,卷期:2012年109-13]
- Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathway...
- Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1
[作者:Wang, Y; Roche, O; Xu, CY; Moriyama, EH; Heir, P; Chung, J; Roos, FC; Chen, YH; Finak, G; Milosevic, M; Wilson, BC; Teh, BT; Park, M; Irwin, MS; Ohh, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4892-4897 , 文章类型: Article,,卷期:2012年109-13]
- Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated and are a...
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