- Extensive chromosomal variation in a recently formed natural allopolyploid species, Tragopogon miscellus (Asteraceae)
[作者:Chester, M; Gallagher, JP; Symonds, VV; da Silva, AVC; Mavrodiev, EV; Leitch, AR; Soltis, PS; Soltis, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1176-1181 , 文章类型: Article,,卷期:2012年109-4]
- Polyploidy, or whole genome duplication, has played a major role in the evolution of many eukaryotic lineages. Although the prevalence of polyploidy in plants is well documented, the molecular and cytological consequence...
- A morphologically specialized soldier caste improves colony defense in a neotropical eusocial bee
[作者:Gruter, C; Menezes, C; Imperatriz-Fonseca, VL; Ratnieks, FLW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1182-1186 , 文章类型: Article,,卷期:2012年109-4]
- Division of labor among workers is common in insect societies and is thought to be important in their ecological success. In most species, division of labor is based on age (temporal castes), but workers in some ants and...
- Divergence of duplicate genes in exon-intron structure
[作者:Xu, GX; Guo, CC; Shan, HY; Kong, HZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1187-1192 , 文章类型: Article,,卷期:2012年109-4]
- Gene duplication plays key roles in organismal evolution. Duplicate genes, if they survive, tend to diverge in regulatory and coding regions. Divergences in coding regions, especially those that can change the function o...
- The mystery of missing heritability: Genetic interactions create phantom heritability
[作者:Zuk, O; Hechter, E; Sunyaev, SR; Lander, ES,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1193-1198 , 文章类型: Article,,卷期:2012年109-4]
- Human genetics has been haunted by the mystery of "missing heritability" of common traits. Although studies have discovered >1,200 variants associated with common diseases and traits, these variants typically appear to e...
- Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1
[作者:Cui, CY; Childress, V; Piao, Y; Michel, M; Johnson, AA; Kunisada, M; Ko, MSH; Kaestner, KH; Marmorstein, AD; Schlessinger, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1199-1203 , 文章类型: Article,,卷期:2012年109-4]
- Body temperature is maintained in a narrow range in mammals, primarily controlled by sweating. In humans, the dynamic thermoregulatory organ, comprised of 2-4 million sweat glands distributed over the body, can secrete u...
- Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
[作者:Barreiro, LB; Tailleux, L; Pai, AA; Gicquel, B; Marioni, JC; Gilad, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1204-1209 , 文章类型: Article,,卷期:2012年109-4]
- Tuberculosis (TB) is a major public health problem. One-third of the world's population is estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent causing TB, and active disease kills nearly...
- Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8(+) T-cell immunity
[作者:Lang, PA; Lang, KS; Xu, HFC; Grusdat, M; Parish, IA; Recher, M; Elford, AR; Dhanji, S; Shaabani, N; Tran, CW; Dissanayake, D; Rahbar, R; Ghazarian, M; Brustle, A; Fine, J; Chen, P; Weaver, CT; Klose, C; Diefenbach, A; Haussinger, D; Carlyle, JR; Kaech, SM; Maka, TW; Ohashi, PS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1210-1215 , 文章类型: Article,,卷期:2012年109-4]
- Infections with HIV, hepatitis B virus, and hepatitis C virus can turn into chronic infections, which currently affect more than 500 million patients worldwide. It is generally thought that virus-mediated T-cell exhausti...
- Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1
[作者:Kanehiro, Y; Todo, K; Negishi, M; Fukuoka, J; Gan, WJ; Hikasa, T; Kaga, Y; Takemoto, M; Magari, M; Li, XL; Manley, JL; Ohmori, H; Kanayama, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1216-1221 , 文章类型: Article,,卷期:2012年109-4]
- Somatic hypermutation (SHM) of Ig variable region (IgV) genes requires both IgV transcription and the enzyme activation-induced cytidine deaminase (AID). Identification of a cofactor responsible for the fact that IgV gen...
- Chlamydophila pneumoniae phospholipase D (CpPLD) drives Th17 inflammation in human atherosclerosis
[作者:Benagiano, M; Munari, F; Ciervo, A; Amedei, A; Paccani, SR; Mancini, F; Ferrari, M; Della Bella, C; Ulivi, C; D'Elios, S; Baldari, CT; Prisco, D; de Bernard, M; D'Elios, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1222-1227 , 文章类型: Article,,卷期:2012年109-4]
- Phospholipases are produced from bacterial pathogens causing very different diseases. One of the most intriguing aspects of phospholipases is their potential to interfere with cellular signaling cascades and to modulate ...
- CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi
[作者:Hawley, KL; Olson, CM; Iglesias-Pedraz, JM; Navasa, N; Cervantes, JL; Caimano, MJ; Izadi, H; Ingalls, RR; Pal, U; Salazar, JC; Radolf, JD; Anguita, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1228-1232 , 文章类型: Article,,卷期:2012年109-4]
- Phagocytosis of Borrelia burgdorferi, the causative agent of Lyme disease, is a poorly understood process, despite its importance during the host immune response to infection. B. burgdorferi has been shown to bind to dif...
- T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease
[作者:Gil-Cruz, C; Perez-Shibayama, C; Firner, S; Waisman, A; Bechmann, I; Thiel, V; Cervantes-Barragan, L; Ludewig, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1233-1238 , 文章类型: Article,,卷期:2012年109-4]
- Generation of antiviral IgM is usually considered as a marker of a short-lived initial antibody response that is replaced by hyper-mutated and more-efficient IgG. However, once viruses have established a particular niche...
- Digoxin inhibits development of hypoxic pulmonary hypertension in mice
[作者:Abud, EM; Maylor, J; Undem, C; Punjabi, A; Zaiman, AL; Myers, AC; Sylvester, JT; Semenza, GL; Shimoda, LA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1239-1244 , 文章类型: Article,,卷期:2012年109-4]
- Chronic hypoxia is an inciting factor for the development of pulmonary arterial hypertension. The mechanisms involved in the development of hypoxic pulmonary hypertension (HPH) include hypoxia-inducible factor 1 (HIF-1)-...
- Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes
[作者:Hinson, SR; Romero, MF; Popescu, BFG; Lucchinetti, CF; Fryer, JP; Wolburg, H; Fallier-Becker, P; Noell, S; Lennon, VA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1245-1250 , 文章类型: Article,,卷期:2012年109-4]
- The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection ...
- Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis
[作者:Cummings, HE; Barbi, J; Reville, P; Oghumu, S; Zorko, N; Sarkar, A; Keiser, TL; Lu, B; Ruckle, T; Varikuti, S; Lezama-Davila, C; Wewers, MD; Whitacre, C; Radzioch, D; Rommel, C; Seveau, S; Satoskar, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1251-1256 , 文章类型: Article,,卷期:2012年109-4]
- Obligate intracellular pathogens such as Leishmania specifically target host phagocytes for survival and replication. Phosphoinositide 3-kinase gamma (PI3K gamma), a member of the class I PI3Ks that is highly expressed b...
- Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis
[作者:Madigan, CA; Cheng, TY; Layre, E; Young, DC; McConnell, MJ; Debono, CA; Murry, JP; Wei, JR; Barry, CE; Rodriguez, GM; Matsunaga, I; Rubin, EJ; Moody, DB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1257-1262 , 文章类型: Article,,卷期:2012年109-4]
- To measure molecular changes underlying pathogen adaptation, we generated a searchable dataset of more than 12,000 mass spectrometry events, corresponding to lipids and small molecules that constitute a lipidome for Myco...
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