- Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy
[作者:Sakata, E; Bohn, S; Mihalache, O; Kiss, P; Beck, F; Nagy, I; Nickell, S; Tanaka, K; Saeki, Y; Forster, F; Baumeister, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1479-1484 , 文章类型: Article,,卷期:2012年109-5]
- Two canonical subunits of the 26S proteasome, Rpn10 and Rpn13, function as ubiquitin (Ub) receptors. The mutual arrangement of these subunits-and all other non-ATPase subunits-in the regulatory particle is unknown. Using...
- Full-length myosin Va exhibits altered gating during processive movement on actin
[作者:Armstrong, JM; Krementsova, E; Michalek, AJ; Heaslip, AT; Nelson, SR; Trybus, KM; Warshaw, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E218-E224 , 文章类型: Article,,卷期:2012年109-5]
- Myosin Va (myoV) is a processive molecular motor that transports intracellular cargo along actin tracks with each head taking multiple 72-nm hand-over-hand steps. This stepping behavior was observed with a constitutively...
- Evolution of patterns on Conus shells
[作者:Gong, ZQ; Matzke, NJ; Ermentrout, B; Song, D; Vendetti, JE; Slatkin, M; Oster, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E234-E241 , 文章类型: Article,,卷期:2012年109-5]
- The pigmentation patterns of shells in the genus Conus can be generated by a neural-network model of the mantle. We fit model parameters to the shell pigmentation patterns of 19 living Conus species for which a well reso...
- Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer
[作者:Anthony, PC; Perez, CF; Garcia-Garcia, C; Block, SM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1485-1489 , 文章类型: Article,,卷期:2012年109-5]
- Riboswitches are motifs in the untranslated regions (UTRs) of RNA transcripts that sense metabolite levels and modulate the expression of the corresponding genes for metabolite import, export, synthesis, or degradation. ...
- Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment
[作者:Morrone, S; Cheng, ZH; Moon, RT; Cong, F; Xu, WQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1500-1505 , 文章类型: Article,,卷期:2012年109-5]
- Axin is a tumor suppressor and a key negative regulator of the Wnt/beta-catenin signaling pathway. Axin turnover is controlled by its poly-ADP-ribosylation catalyzed by tankyrase (TNKS), which requires the direct interac...
- The channel kinase, TRPM7, is required for early embryonic development
[作者:Jin, J; Wu, LJ; Jun, J; Cheng, XP; Xu, HX; Andrews, NC; Clapham, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E225-E233 , 文章类型: Article,,卷期:2012年109-5]
- Global disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic lethality before embryonic day 7. Using tamoxifen-inducible disruption of Trpm7 and multiple Cre recombinase lines,...
- Glycogen synthase kinase 3 beta transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels
[作者:Rottlaender, D; Boengler, K; Wolny, M; Schwaiger, A; Motloch, LJ; Ovize, M; Schulz, R; Heusch, G; Hoppe, UC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E242-E251 , 文章类型: Article,,卷期:2012年109-5]
- Despite compelling evidence supporting key roles for glycogen synthase kinase 3 beta (GSK3 beta), mitochondrial adenosine triphosphate-sensitive K+ (mitoK(ATP)) channels, and mitochondrial connexin 43 (Cx43) in cytoprote...
- Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
[作者:Ruivo, R; Bellenchi, GC; Chen, X; Zifarelli, G; Sagne, C; Debacker, C; Pusch, M; Supplisson, S; Gasnier, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E210-E217 , 文章类型: Article,,卷期:2012年109-5]
- Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs "uphill" across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual...
- Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer
[作者:Shain, AH; Giacomini, CP; Matsukuma, K; Karikari, CA; Bashyam, MD; Hidalgo, M; Maitra, A; Pollack, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E252-E259 , 文章类型: Article,,卷期:2012年109-5]
- Defining the molecular genetic alterations underlying pancreatic cancer may provide unique therapeutic insight for this deadly disease. Toward this goal, we report here an integrative DNA microarray and sequencing-based ...
- Spatial organization of the extracellular matrix regulates cell-cell junction positioning
[作者:Tseng, QZ; Duchemin-Pelletier, E; Deshiere, A; Balland, M; Guillou, H; Filhol, O; Thery, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1506-1511 , 文章类型: Article,,卷期:2012年109-5]
- The organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ECM) and adjacent cells. The role of cell-cell adhesion in the regulation of epithelial topology is well-described...
- Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
[作者:Mergenthaler, P; Kahl, A; Kamitz, A; van Laak, V; Stohlmann, K; Thomsen, S; Klawitter, H; Przesdzing, I; Neeb, L; Freyer, D; Priller, J; Collins, TJ; Megow, D; Dirnagl, U; Andrews, DW; Meisel, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1518-1523 , 文章类型: Article,,卷期:2012年109-5]
- The metabolic state of a cell is a key determinant in the decision to live and proliferate or to die. Consequently, balanced energy metabolism and the regulation of apoptosis are critical for the development and maintena...
- Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription
[作者:Deng, WS; Lopez-Camacho, C; Tang, JY; Mendoza-Villanueva, D; Maya-Mendoza, A; Jackson, DA; Shore, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1524-1529 , 文章类型: Article,,卷期:2012年109-5]
- Filamin A (FLNA) is an actin-binding protein with a well-established role in the cytoskeleton, where it determines cell shape and locomotion by cross-linking actin filaments. Mutations in FLNA are associated with a wide ...
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