- On relaxations and aging of various glasses
[作者:Amir, A; Oreg, Y; Imry, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1850-1855 , 文章类型: Article,,卷期:2012年109-6]
- Slow relaxation occurs in many physical and biological systems. "Creep" is an example from everyday life. When stretching a rubber band, for example, the recovery to its equilibrium length is not, as one might think, exp...
- Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection
[作者:Fanning, S; Hall, LJ; Cronin, M; Zomer, A; MacSharry, J; Goulding, D; Motherway, MO; Shanahan, F; Nally, K; Dougan, G; van Sinderen, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2108-2113 , 文章类型: Article,,卷期:2012年109-6]
- Bifidobacteria comprise a significant proportion of the human gut microbiota. Several bifidobacterial strains are currently used as therapeutic interventions, claiming various health benefits by acting as probiotics. How...
- Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires
[作者:Miller, EW; Lin, JY; Frady, EP; Steinbach, PA; Kristan, WB; Tsien, RY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2114-2119 , 文章类型: Article,,卷期:2012年109-6]
- Fluorescence imaging is an attractive method for monitoring neuronal activity. A key challenge for optically monitoring voltage is development of sensors that can give large and fast responses to changes in transmembrane...
- Maternal modulation of novelty effects on physical development
[作者:Tang, AC; Yang, Z; Reeb-Sutherland, BC; Romeo, RD; McEwen, BS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2120-2125 , 文章类型: Article,,卷期:2012年109-6]
- Familiarity to the mother and the novelty afforded by the postnatal environment are two contrasting sources of neonatal influence. One hypothesis regarding their relationship is the maternal modulation hypothesis, which ...
- Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
[作者:Beltran, WA; Cideciyan, AV; Lewin, AS; Iwabe, S; Khanna, H; Sumaroka, A; Chiodo, VA; Fajardo, DS; Roman, AJ; Deng, WT; Swider, M; Aleman, TS; Boye, SL; Genini, S; Swaroop, A; Hauswirth, WW; Jacobson, SG; Aguirre, GD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2132-2137 , 文章类型: Article,,卷期:2012年109-6]
- Hereditary retinal blindness is caused by mutations in genes expressed in photoreceptors or retinal pigment epithelium. Gene therapy in mouse and dog models of a primary retinal pigment epithelium disease has already bee...
- Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
[作者:Carhart-Harris, RL; Erritzoe, D; Williams, T; Stone, JM; Reed, LJ; Colasanti, A; Tyacke, RJ; Leech, R; Malizia, AL; Murphy, K; Hobden, P; Evans, J; Feilding, A; Wise, RG; Nutt, DJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2138-2143 , 文章类型: Article,,卷期:2012年109-6]
- Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about how they work in the brain. Here we used psilocybin, ...
- Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors
[作者:Bard-Chapeau, EA; Jeyakani, J; Kok, CH; Muller, J; Chua, BQ; Gunaratne, J; Batagov, A; Jenjaroenpun, P; Kuznetsov, VA; Wei, CL; D'Andrea, RJ; Bourque, G; Jenkins, NA; Copeland, NG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2168-2173 , 文章类型: Article,,卷期:2012年109-6]
- Ecotropic viral integration site 1 (EVI1) is an oncogenic dual domain zinc finger transcription factor that plays an essential role in the regulation of hematopoietic stem cell renewal, and its overexpression in myeloid ...
- Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia
[作者:Bottos, A; Martini, M; Di Nicolantonio, F; Comunanza, V; Maione, F; Minassi, A; Appendino, G; Bussolino, F; Bardelli, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E353-E359 , 文章类型: Article,,卷期:2012年109-6]
- Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the epithelial compartment influences tumor angiogenesis is largely une...
- DNA charge transport as a first step in coordinating the detection of lesions by repair proteins
[作者:Sontz, PA; Mui, TP; Fuss, JO; Tainer, JA; Barton, JK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1856-1861 , 文章类型: Article,,卷期:2012年109-6]
- Damaged bases in DNA are known to lead to errors in replication and transcription, compromising the integrity of the genome. We have proposed a model where repair proteins containing redoxactive [4Fe-4S] clusters utilize...
- pH-controlled delivery of luminescent europium coated nanoparticles into platelets
[作者:Davies, A; Lewis, DJ; Watson, SP; Thomas, SG; Pikramenou, Z,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1862-1867 , 文章类型: Article,,卷期:2012年109-6]
- Water soluble, luminescent gold nanoparticles are delivered into human platelets via a rapid, pH-controlled mechanism using a pH low insertion peptide, pHLIP. The approach introduces cocoating of gold nanoparticles with ...
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