A novel one-pot tandem asymmetric Hantzsch-type process has been employed to generate fluorinated 1,4-dihydropyridines (1,4-DHPs) as single diastereoisomers. It involves the condensation of (R)-(+)-allyl p-tolyl sulfoxid...
Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic a...
A new variation on the Boulton-Katritzky reaction is reported, namely, involving use of a CNC side chain. A novel Montmorillonite-K10 catalyzed nonreductive transamination of a 3-benzoyl-1,2,4-oxadiazole afforded a 3-(al...
A nickel-catalyzed intramolecular cyclization of alkynylalkanone in the presence of Et3SiH using an NHC ligand produced various carbo- and heterocycles In a stereoselective manner. The reaction would proceed via formatio...
A new family of optically active 2,3-dihydrobenzofurans has been prepared by a simple chemoenzymatic asymmetric strategy. This synthetic approach is based on the combination of a lipase-mediated kinetic resolution of 1-a...
A highly enantioselective direct Mannich-type reaction of aldimines with dialkyl malonates was developed with the use of a Mg(II)-BINOLate salt, which was designed as a cooperative acid-base catalyst that can activate bo...
Switchable access to dihydropyrazoles and pyrazoles has been developed from common hydrazides by reagent-controlled iodocyclization. Controlling the oxidative aromatization In iodocyclization for heterocycles is reported...
Newly synthesized 6-O-(2-anthroyl)amylose (AC-Am; 51% substitution) was photolyzed in (aqueous) DMSO solutions to give HH dimers as major products (after saponification), with modest enantiomeric excesses (ee) of 12-15% ...
The usefulness of azopyridinium methyl Iodide salts for designing new promising light-controlled molecular switches is presented. Large absorbance changes have been produced in the samples by Irradiation with light at la...
An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the ...
The pimaricin-inducing (PI) factor, produced by Streptomyces natalensis is a proposed pheromone with a peculiar vicinal diamine structure. The first synthesis of this molecule is reported. It features oxidative dimerizat...