- (S,S)-(+)-Pseudoephedrine a-Iminoglyoxylamide as a Chiral Glycine Cation Equivalent: A Modular and Flexible Approach to Enantioenriched a-Amino Ketones.
[作者:Ruiz, Nerea;Vicario, Jose L.;Badia, Dolores;Carrillo, Luisa;Alonso, Beatriz;,期刊:Organic Letters, 页码:2613-2616 , 文章类型: 研究论文,,卷期:2008年10-12]
- We have studied the ability of an a-imino glyoxylamide derived from (S,S)-(+)-pseudoephedrine as a valuable chiral electrophile for the prepn. of a-amino carbonyl compds. In this context, the addn. of Grignard reagents ...
- Exiguaquinol: A Novel Pentacyclic Hydroquinone from Neopetrosia exigua that Inhibits Helicobacter pylori MurI.
[作者:de Almeida Leone, Priscila;Carroll, Anthony R.;Towerzey, Leanne;King, Gordon;McArdle, Bernadette M.;Kern, Gunther;Fisher, Stewart;Hooper, John N. A.;Quinn, Ronald J.;,期刊:Organic Letters, 页码:2585-2588 , 文章类型: 研究论文,,卷期:2008年10-12]
- sponge Neopetrosia exigua led to the isolation of exiguaquinol (I), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC50 of 4.4 mM. Its structure and relative configur...
- Synthesis of dehydro-b-amino esters via highly regioselective amination of allylic carbonates.
[作者:Benfatti, Fides;Cardillo, Giuliana;Gentilucci, Luca;Mosconi, Elisa;Tolomelli, Alessandra;,期刊:Organic Letters, 页码:2425-2428 , 文章类型: 研究论文,,卷期:2008年10-12]
- The allylic amination of acetates and carbonates affords dehydro-b-aminoesters, which are useful precursors of biol. active compds. The uncatalyzed reaction proceeds via a SN2' mechanism. On the other hand, under pallad...
- A Direct Stereoselective Approach to trans-2,3-Disubstituted Piperidines: Application in the Synthesis of 2-Epi-CP-99,994 and (+)-Epilupinine.
[作者:Ahari, M'hamed;Perez, Amandine;Menant, Christine;Vasse, Jean-Luc;Szymoniak, Jan;,期刊:Organic Letters, 页码:2473-2476 , 文章类型: 研究论文,,卷期:2008年10-12]
- described, offering a straightforward access to the trans-2,3-disubstituted piperidine skeleton which is present in a broad range of biol. active compds. The direct stereoselective approach to trans-2,3-disubstituted pi...
- Stereoselective Total Syntheses of Uncommon Sesquiterpenoids Isolated from Jatropha neopauciflora.
[作者:Hayashi, Yujiro;Miyakoshi, Naoki;Kitagaki, Shinji;Mukai, Chisato;,期刊:Organic Letters, 页码:2385-2388 , 文章类型: 研究论文,,卷期:2008年10-12]
- The first total syntheses of two tricyclic sesquiterpenes I (R = H) and I (R = COMe), isolated from Jatropha neopauciflora, were completed from di-Me D-tartrate in a stereoselective manner. The crucial steps in these sy...
- Silaborations of 1,3-Enynes - Substrate Controlled Allene/1,3-Diene Selectivity.
[作者:Lueken, Christian;Moberg, Christina;,期刊:Organic Letters, 页码:2505-2508 , 文章类型: 研究论文,,卷期:2008年10-12]
- Silaboration of 1,3-enynes catalyzed by group 10 metal complexes affords 1,3-dienes with vinylborane and vinylsilane functions or 1,2-dienes with allylborane and vinylsilane functions. Thus, Pd(acac)2/PEt3 catalyzed sil...
- Synthesis of Large Macrocyclic Azacalix[n]pyridines (n = 6 - 9) and Their Complexation with Fullerenes C60 and C70.
[作者:Zhang, En-Xuan;Wang, De-Xian;Zheng, Qi-Yu;Wang, Mei-Xiang;,期刊:Organic Letters, 页码:2565-2568 , 文章类型: 研究论文,,卷期:2008年10-12]
- Large methylazacalix[n]pyridines (n = 6-9) were synthesized effectively from the Pd-catalyzed macrocyclic fragment coupling reactions between a,w-dibrominated and a,w-diaminated linear oligomers. As macrocyclic host mol...
- A Preparation of Enantiomerically Enriched Axially Chiral b-Diketimines: Synthesis of (-)- and (+)-IAN Amine.
[作者:Luesse, Sarah B.;Counceller, Carla M.;Wilt, Jeremy C.;Perkins, Brittany R.;Johnston, Jeffrey N.;,期刊:Organic Letters, 页码:2445-2447 , 文章类型: 研究论文,,卷期:2008年10-12]
- The prepn. of an enantiomerically enriched b-diketimine I composed of isoquinoline and 2-aminonaphthalene (IAN amine) is described, thereby offering new opportunities in the synthesis of nonracemic b-diketimine- and pyri...
- One-Pot Syntheses of 2,3-Dihydrothiopyran-4-one Derivatives by Pd/Cu-Catalyzed Reactions of a,b-Unsaturated Thioesters with Propargyl Alcohols.
[作者:Minami, Yasunori;Kuniyasu, Hitoshi;Kambe, Nobuaki;,期刊:Organic Letters, 页码:2469-2472 , 文章类型: 研究论文,,卷期:2008年10-12]
- 2,3-Dihydrothiopyran-4-one derivs. were readily prepd. by Pd/Cu-catalyzed reactions between a,b-unsatd. thioesters and propargyl alcs. in the presence of bases. E.g., in presence of PdCl2, CuI, and K2CO3, cyclization of...
- Enantioselective Assembly of Substituted Dihydropyrones via Organocatalytic Reaction in Water Media.
[作者:Wang, Jing;Yu, Fang;Zhang, Xiaojing;Ma, Dawei;,期刊:Organic Letters, 页码:2561-2564 , 文章类型: 研究论文,,卷期:2008年10-12]
- The diarylprolinol ether/AcOH-catalyzed cascade Michael addn. and cyclization of aldehydes and a-keto-a,b-unsatd. esters proceeds smoothly in water to afford cyclic hemiacetals, e.g. I [R = H2C:CH(CH2)6CH2, PhCH2OCH2CH2,...
- Synthesis of the C1-C23 Fragment of Spirastrellolide A.
[作者:Yang, Jin-Haek;Liu, Jia;Hsung, Richard P.;,期刊:Organic Letters, 页码:2525-2528 , 文章类型: 研究论文,,卷期:2008年10-12]
- Synthesis of the C1-C23 fragment I in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3-anti aldol involving Me ketone enolate and Mukaiyam...
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