- Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans
[作者:Wrammert, J; Onlamoon, N; Akondy, RS; Perng, GC; Polsrila, K; Chandele, A; Kwissa, M; Pulendran, B; Wilson, PC; Wittawatmongkol, O; Yoksan, S; Angkasekwinai, N; Pattanapanyasat, K; Chokephaibulkit, K; Ahmed, R,期刊:Journal of virology, 页码:2911-2918 , 文章类型: Article,,卷期:2012年86-6]
- Humoral immune responses are thought to play a major role in dengue virus-induced immunopathology; however, little is known about the plasmablasts producing these antibodies during an ongoing infection. Herein we present...
- Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane
[作者:Montero, M; Gulzar, N; Klaric, KA; Donald, JE; Lepik, C; Wu, S; Tsai, S; Julien, JP; Hessell, AJ; Wang, SX; Lu, S; Burton, DR; Pai, EF; DeGrado, WF; Scott, JK,期刊:Journal of virology, 页码:2930-2941 , 文章类型: Article,,卷期:2012年86-6]
- Failure to elicit broadly neutralizing (bNt) antibodies (Abs) against the membrane-proximal external region of HIV-1 gp41 (MPER) reflects the difficulty of mimicking its neutralization-competent structure (NCS). Here, we...
- Protruding Domain of Capsid Protein Is Necessary and Sufficient To Determine Murine Norovirus Replication and Pathogenesis In Vivo
[作者:Strong, DW; Thackray, LB; Smith, TJ; Virgin, HW,期刊:Journal of virology, 页码:2950-2958 , 文章类型: Article,,卷期:2012年86-6]
- Human noroviruses (HuNoVs) are the major cause of epidemic, nonbacterial gastroenteritis worldwide. Due to the lack of a tractable model system and the inability to grow HuNoVs in cell culture, factors required for the n...
- Entry of Human T-Cell Leukemia Virus Type 1 Is Augmented by Heparin Sulfate Proteoglycans Bearing Short Heparin-Like Structures
[作者:Tanaka, A; Jinno-Oue, A; Shimizu, N; Hoque, A; Mori, T; Islam, S; Nakatani, Y; Shinagawa, M; Hoshino, H,期刊:Journal of virology, 页码:2959-2969 , 文章类型: Article,,卷期:2012年86-6]
- Three molecules have been identified as the main cellular factors required for binding and entry of human T-cell leukemia virus type 1 (HTLV-1): glucose transporter 1 (GLUT1), heparan sulfate (HS), and neuropilin 1 (NRP-...
- Detection of Murine Leukemia Virus in the Epstein-Barr Virus-Positive Human B-Cell Line JY, Using a Computational RNA-Seq-Based Exogenous Agent Detection Pipeline, PARSES
[作者:Lin, Z; Puetter, A; Coco, J; Xu, GR; Strong, MJ; Wang, X; Fewell, C; Baddoo, M; Taylor, C; Flemington, EK,期刊:Journal of virology, 页码:2970-2977 , 文章类型: Article,,卷期:2012年86-6]
- Many cell lines commonly used for biological studies have been found to harbor exogenous agents such as the human tumor viruses Epstein-Barr virus (EBV) and human papillomavirus. Nevertheless, broad-based, unbiased appro...
- A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses
[作者:Hu, HX; Voss, J; Zhang, GL; Buchy, P; Zuo, T; Wang, LL; Wang, F; Zhou, F; Wang, GQ; Tsai, CG; Calder, L; Gamblin, SJ; Zhang, LQ; Deubel, V; Zhou, BP; Skehel, JJ; Zhou, P,期刊:Journal of virology, 页码:2978-2989 , 文章类型: Article,,卷期:2012年86-6]
- Influenza A virus infection is a persistent threat to public health worldwide due to its ability to evade immune surveillance through rapid genetic drift and shift. Current vaccines against influenza A virus provide immu...
- Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag
[作者:Grewe, B; Hoffmann, B; Ohs, I; Blissenbach, M; Brandt, S; Tippler, B; Grunwald, T; Uberla, K,期刊:Journal of virology, 页码:2990-3002 , 文章类型: Article,,卷期:2012年86-6]
- In some retroviruses, such as Rous sarcoma virus and prototype foamy virus, Gag proteins are known to shuttle between the nucleus and the cytoplasm and are implicated in nuclear export of the viral genomic unspliced RNA ...
- Beyond Anchoring: the Expanding Role of the Hendra Virus Fusion Protein Transmembrane Domain in Protein Folding, Stability, and Function
[作者:Smith, EC; Culler, MR; Hellman, LM; Fried, MG; Creamer, TP; Dutch, RE,期刊:Journal of virology, 页码:3003-3013 , 文章类型: Article,,卷期:2012年86-6]
- While work with viral fusion proteins has demonstrated that the transmembrane domain (TMD) can affect protein folding, stability, and membrane fusion promotion, the mechanism(s) remains poorly understood. TMDs could play...
- Impact of HLA-B(star)81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity
[作者:Wright, JK; Naidoo, VL; Brumme, ZL; Prince, JL; Claiborne, DT; Goulder, PJR; Brockman, MA; Hunter, E; Ndung'u, T,期刊:Journal of virology, 页码:3193-3199 , 文章类型: Article,,卷期:2012年86-6]
- HIV-1 attenuation resulting from immune escape mutations selected in Gag may contribute to slower disease progression in HIV-1-infected individuals expressing certain HLA class I alleles. We previously showed that the pr...
- Postexposure Treatment with the Live-Attenuated Rabies Virus (RV) Vaccine TriGAS Triggers the Clearance of Wild-Type RV from the Central Nervous System (CNS) through the Rapid Induction of Genes Relevant to Adaptive Immunity in CNS Tissues
[作者:Li, JW; Ertel, A; Portocarrero, C; Barkhouse, DA; Dietzschold, B; Hooper, DC; Faber, M,期刊:Journal of virology, 页码:3200-3210 , 文章类型: Article,,卷期:2012年86-6]
- Postexposure treatment (PET) of wild-type rabies virus (RV)-infected mice with a live-attenuated triple-glycoprotein RV variant (TriGAS) promotes survival but does not prevent the pathogenic RV from invading and replicat...
- Varicella-Zoster Virus Infects Human Embryonic Stem Cell-Derived Neurons and Neurospheres but Not Pluripotent Embryonic Stem Cells or Early Progenitors
[作者:Dukhovny, A; Sloutskin, A; Markus, A; Yee, MB; Kinchington, PR; Goldstein, RS,期刊:Journal of virology, 页码:3211-3218 , 文章类型: Article,,卷期:2012年86-6]
- Pluripotent human stem cells are a powerful tool for the generation of differentiated cells that can be used for the study of human disease. We recently demonstrated that neurons derived from pluripotent human embryonic ...
- Contribution of Intra- and Interhost Dynamics to Norovirus Evolution
[作者:Bull, RA; Eden, JS; Luciani, F; McElroy, K; Rawlinson, WD; White, PA,期刊:Journal of virology, 页码:3219-3229 , 文章类型: Article,,卷期:2012年86-6]
- Norovirus (NoV) is an emerging RNA virus that has been associated with global epidemics of gastroenteritis. Each global epidemic arises with the emergence of novel antigenic variants. While the majority of NoV infections...
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