- Recruitment of the Nuclear Form of Uracil DNA Glycosylase into Virus Particles Participates in the Full Infectivity of HIV-1
[作者:Guenzel, CA; Herate, C; Le Rouzic, E; Maidou-Peindara, P; Sadler, HA; Rouyez, MC; Mansky, LM; Benichou, S,期刊:Journal of virology, 页码:2533-2544 , 文章类型: Article,,卷期:2012年86-5]
- The HIV-1 Vpr protein participates in the early steps of the virus life cycle by influencing the accuracy of reverse transcription. This role of Vpr was related to the recruitment of the nuclear form of the uracil DNA gl...
- Baculovirus-Encoded Protein BV/ODV-E26 Determines Tissue Tropism and Virulence in Lepidopteran Insects
[作者:Katsuma, S; Kobayashi, J; Koyano, Y; Matsuda-Imai, N; Kang, WK; Shimadaa, T,期刊:Journal of virology, 页码:2545-2555 , 文章类型: Article,,卷期:2012年86-5]
- Lepidopteran nucleopolyhedroviruses (NPVs) show distinct tissue tropism in host insect larvae. However, the molecular mechanism of this tropism is largely unknown. We quantitatively investigated NPV tissue tropism by mea...
- Differential Transmission of HIV Traversing Fetal Oral/Intestinal Epithelia and Adult Oral Epithelia
[作者:Tugizov, SM; Herrera, R; Veluppillai, P; Greenspan, D; Soros, V; Greene, WC; Levy, JA; Palefsky, JM,期刊:Journal of virology, 页码:2556-2570 , 文章类型: Article,,卷期:2012年86-5]
- While human immunodeficiency virus (HIV) transmission through the adult oral route is rare, mother-to-child transmission (MTCT) through the neonatal/infant oral and/or gastrointestinal route is common. To study the mecha...
- The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1
[作者:Chaumorcel, M; Lussignol, M; Mouna, L; Cavignac, Y; Fahie, K; Cotte-Laffitte, J; Geballe, A; Brune, W; Beau, I; Codogno, P; Esclatine, A,期刊:Journal of virology, 页码:2571-2584 , 文章类型: Article,,卷期:2012年86-5]
- Human cytomegalovirus modulates macroautophagy in two opposite directions. First, HCMV stimulates autophagy during the early stages of infection, as evident by an increase in the number of autophagosomes and a rise in th...
- Interactions of the Cytoplasmic Domain of Sindbis Virus E2 with Nucleocapsid Cores Promote Alphavirus Budding
[作者:Jose, J; Przybyla, L; Edwards, TJ; Perera, R; Burgner, JW; Kuhn, RJ,期刊:Journal of virology, 页码:2585-2599 , 文章类型: Article,,卷期:2012年86-5]
- Alphavirus budding from the plasma membrane occurs through the specific interaction of the nucleocapsid core with the cytoplasmic domain of the E2 glycoprotein (cdE2). Structural studies of the Sindbis virus capsid prote...
- Baculovirus GP64-Mediated Entry into Mammalian Cells
[作者:Kataoka, C; Kaname, Y; Taguwa, S; Abe, T; Fukuhara, T; Tani, H; Moriishi, K; Matsuura, Y,期刊:Journal of virology, 页码:2610-2620 , 文章类型: Article,,卷期:2012年86-5]
- The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) serves as an efficient viral vector, not only for abundant gene expression in insect cells, but also for gene delivery into mammalian cells. L...
- Infectious Spleen and Kidney Necrosis Virus (a Fish Iridovirus) Enters Mandarin Fish Fry Cells via Caveola-Dependent Endocytosis
[作者:Guo, CJ; Wu, YY; Yang, LS; Yang, XB; He, J; Mi, S; Jia, KT; Weng, SP; Yu, XQ; He, JG,期刊:Journal of virology, 页码:2621-2631 , 文章类型: Article,,卷期:2012年86-5]
- Infectious spleen and kidney necrosis virus (ISKNV) is the type species of the genus Megalocytivirus from the family Iridoviridae. Megalocytiviruses have been implicated in more than 50 fish species infections and curren...
- Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library
[作者:Dower, K; Filone, CM; Hodges, EN; Bjornson, ZB; Rubins, KH; Brown, LE; Schaus, S; Hensley, LE; Connor, JH,期刊:Journal of virology, 页码:2632-2640 , 文章类型: Article,,卷期:2012年86-5]
- Orthopoxviruses include the prototypical vaccinia virus, the emerging infectious agent monkeypox virus, and the potential bio-threat variola virus (the causative agent of smallpox). There is currently no FDA-approved dru...
- In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs
[作者:Andrei, G; Topalis, D; Fiten, P; McGuigan, C; Balzarini, J; Opdenakker, G; Snoeck, R,期刊:Journal of virology, 页码:2641-2652 , 文章类型: Article,,卷期:2012年86-5]
- Varicella zoster virus (VZV) is usually associated with mild to moderate illness in immunocompetent patients. However, older age and immune deficiency are the most important risk factors linked with virus reactivation an...
- Bovine Herpesvirus Type 4 Glycoprotein L Is Nonessential for Infectivity but Triggers Virion Endocytosis during Entry
[作者:Lete, C; Machiels, B; Stevenson, PG; Vanderplasschen, A; Gillet, L,期刊:Journal of virology, 页码:2653-2664 , 文章类型: Article,,卷期:2012年86-5]
- The core entry machinery of mammalian herpesviruses comprises glycoprotein B (gB), gH, and gL. gH and gL form a heterodimer with a central role in viral membrane fusion. When archetypal alpha- or betaherpesviruses lack g...
- Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection
[作者:Smith, SA; Zhou, Y; Olivarez, NP; Broadwater, AH; de Silva, AM; Crowe, JE,期刊:Journal of virology, 页码:2665-2675 , 文章类型: Article,,卷期:2012年86-5]
- Symptomatic dengue virus infection ranges in disease severity from an influenza-like illness to life-threatening shock. One model of the mechanism underlying severe disease proposes that weakly neutralizing, dengue serot...
- The Association of Recombination Events in the Founding and Emergence of Subgenogroup Evolutionary Lineages of Human Enterovirus 71
[作者:Leitch, ECM; Cabrerizo, M; Cardosa, J; Harvala, H; Ivanova, OE; Koike, S; Kroes, ACM; Lukashev, A; Perera, D; Roivainen, M; Susi, P; Trallero, G; Evans, DJ; Simmonds, P,期刊:Journal of virology, 页码:2676-2685 , 文章类型: Article,,卷期:2012年86-5]
- Enterovirus 71 (EV71) is responsible for frequent large-scale outbreaks of hand, foot, and mouth disease worldwide and represent a major etiological agent of severe, sometimes fatal neurological disease. EV71 variants ha...
- Identification of Host Genes Linked with the Survivability of Chickens Infected with Recombinant Viruses Possessing H5N1 Surface Antigens from a Highly Pathogenic Avian Influenza Virus
[作者:Uchida, Y; Watanabe, C; Takemae, N; Hayashi, T; Oka, T; Ito, T; Saito, T,期刊:Journal of virology, 页码:2686-2695 , 文章类型: Article,,卷期:2012年86-5]
- Seventeen recombinant viruses were generated by a reverse genetic technique to elucidate the pathogenicity of highly pathogenic avian influenza viruses (HPAIVs) in chickens. The recombinant viruses generated possessed he...
- Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir
[作者:Quashie, PK; Mesplede, T; Han, YS; Oliveira, M; Singhroy, DN; Fujiwara, T; Underwood, MR; Wainberg, MA,期刊:Journal of virology, 页码:2696-2705 , 文章类型: Article,,卷期:2012年86-5]
- Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of HIV-1 integrase to irreversibly link the reverse-transcribed viral DNA to the host genome. INSTIs have proven their high ef...
- The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals
[作者:Suguitan, AL; Matsuoka, Y; Lau, YF; Santos, CP; Vogel, L; Cheng, LI; Orandle, M; Subbarao, K,期刊:Journal of virology, 页码:2706-2714 , 文章类型: Article,,卷期:2012年86-5]
- Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of their hemagglutinin (HA) protein, a recognized virulence motif in ...
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