- Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1
[作者:Lu, J; Yi, LN; Zhao, J; Yu, J; Chen, Y; Lin, MC; Kung, HF; He, ML,期刊:Journal of virology, 页码:3767-3776 , 文章类型: Article,,卷期:2012年86-7]
- The recent outbreak of enterovirus 71 (EV71) infected millions of children and caused over 1,000 deaths. To date, neither an effective vaccine nor antiviral treatment is available for EV71 infection. Interferons (IFNs) h...
- The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication
[作者:Wang, XX; Ao, ZJ; Chen, LY; Kobinger, G; Peng, JY; Yao, XJ,期刊:Journal of virology, 页码:3777-3786 , 文章类型: Article,,卷期:2012年86-7]
- The cytidine deaminase APOBEC3G (A3G) exerts a multifaceted antiviral effect against HIV-1 infection. First, A3G was shown to be able to terminate HIV infection by deaminating the cytosine residues to uracil in the minus...
- Combination of Biological Screening in a Cellular Model of Viral Latency and Virtual Screening Identifies Novel Compounds That Reactivate HIV-1
[作者:Gallastegui, E; Marshall, B; Vidal, D; Sanchez-Duffhues, G; Collado, JA; Alvarez-Fernandez, C; Luque, N; Terme, JM; Gatell, JM; Sanchez-Palomino, S; Munoz, E; Mestres, J; Verdin, E; Jordan, A,期刊:Journal of virology, 页码:3795-3808 , 文章类型: Article,,卷期:2012年86-7]
- Although highly active antiretroviral therapy (HAART) has converted HIV into a chronic disease, a reservoir of HIV latently infected resting T cells prevents the eradication of the virus from patients. To achieve eradica...
- Sangassou Virus, the First Hantavirus Isolate from Africa, Displays Genetic and Functional Properties Distinct from Those of Other Murinae-Associated Hantaviruses
[作者:Klempa, B; Witkowski, PT; Popugaeva, E; Auste, B; Koivogui, L; Fichet-Calvet, E; Strecker, T; ter Meulen, J; Kruger, DH,期刊:Journal of virology, 页码:3819-3827 , 文章类型: Article,,卷期:2012年86-7]
- We have discovered the first indigenous African hantavirus, Sangassou virus (SANGV). The virus was isolated from an African wood mouse (Hylomyscus simus), trapped in a forest habitat in Guinea, West Africa. Here, we repo...
- Mutation of the F-Protein Cleavage Site of Avian Paramyxovirus Type 7 Results in Furin Cleavage, Fusion Promotion, and Increased Replication In Vitro but Not Increased Replication, Tissue Tropism, or Virulence in Chickens
[作者:Xiao, S; Khattar, SK; Subbiah, M; Collins, PL; Samal, SK,期刊:Journal of virology, 页码:3828-3838 , 文章类型: Article,,卷期:2012年86-7]
- We constructed a reverse genetics system for avian paramyxovirus serotype 7 (APMV-7) to investigate the role of the fusion F glycoprotein in tissue tropism and virulence. The AMPV-7 F protein has a single basic residue a...
- Induction of Immunological Tolerance to Adenoviral Vectors by Using a Novel Dendritic Cell-Based Strategy
[作者:Kushwah, R; Oliver, JR; Duan, RQ; Zhang, L; Keshavjee, S; Hu, J,期刊:Journal of virology, 页码:3422-3435 , 文章类型: Article,,卷期:2012年86-7]
- The success of helper-dependent adenoviral (HD-Ad) vector-mediated lung gene therapy is hampered by the host immune response, which limits pulmonary transgene expression following multiple rounds of vector readminstratio...
- Tissue Exit: a Novel Control Point in the Accumulation of Antigen-Specific CD8 T Cells in the Influenza A Virus-Infected Lung
[作者:Jennrich, S; Lee, MH; Lynn, RC; Dewberry, K; Debes, GF,期刊:Journal of virology, 页码:3436-3445 , 文章类型: Article,,卷期:2012年86-7]
- Memory/effector T cells efficiently migrate into extralymphoid tissues and sites of infection, providing immunosurveillance and a first line of defense against invading pathogens. Even though it is a potential means to r...
- Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid
[作者:Allaume, X; El-Andaloussi, N; Leuchs, B; Bonifati, S; Kulkarni, A; Marttila, T; Kaufmann, JK; Nettelbeck, DM; Kleinschmidt, J; Rommelaere, J; Marchini, A,期刊:Journal of virology, 页码:3452-3465 , 文章类型: Article,,卷期:2012年86-7]
- The rat parvovirus H-1PV is a promising anticancer agent given its oncosuppressive properties and the absence of known side effects in humans. H-1PV replicates preferentially in transformed cells, but the virus can enter...
- Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15
[作者:Sun, Z; Li, YH; Ransburgh, R; Snijder, EJ; Fang, Y,期刊:Journal of virology, 页码:3839-3850 , 文章类型: Article,,卷期:2012年86-7]
- Type I interferon (alpha/beta interferon [IFN-alpha/beta]) stimulates the expression of interferon-stimulated gene 15 (ISG15), which encodes a ubiquitin-like protein, ISG15. Free ISG15 and ISG15 conjugates function in di...
- HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6
[作者:Lee, K; Mulky, A; Yuen, W; Martin, TD; Meyerson, NR; Choi, L; Yu, H; Sawyer, SL; KewalRamani, VN,期刊:Journal of virology, 页码:3851-3860 , 文章类型: Article,,卷期:2012年86-7]
- The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1) infection through an interaction with capsid (CA), preventing virus nuclear entry and integration. HIV-1 acquires resistance to CPSF6-3...
- Correlation of Recombinant Integrase Activity and Functional Preintegration Complex Formation during Acute Infection by Replication-Defective Integrase Mutant Human Immunodeficiency Virus
[作者:Li, X; Koh, Y; Engelman, A,期刊:Journal of virology, 页码:3861-3879 , 文章类型: Article,,卷期:2012年86-7]
- Previous studies characterized two types of replication-defective human immunodeficiency virus type 1 (HIV-1) integrase mutants: class I, which are specifically blocked at the integration step, and class II, which harbor...
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