- Analysis of Hepatitis C Virus Intrahost Diversity across the Coding Region by Ultradeep Pyrosequencing
[作者:Lauck, M; Alvarado-Mora, MV; Becker, EA; Bhattacharya, D; Striker, R; Hughes, AL; Carrilho, FJ; O'Connor, DH; Pinho, JRR,期刊:Journal of virology, 页码:3952-3960 , 文章类型: Article,,卷期:2012年86-7]
- Hepatitis C virus (HCV) is the leading cause of liver disease worldwide. In this study, we analyzed four treatment-naive patients infected with subtype 1a and performed Roche/454 pyrosequencing across the coding region. ...
- Role of Conserved Cysteine Residues in Hepatitis C Virus Glycoprotein E2 Folding and Function
[作者:McCaffrey, K; Boo, I; Tewierek, K; Edmunds, ML; Poumbourios, P; Drummer, HE,期刊:Journal of virology, 页码:3961-3974 , 文章类型: Article,,卷期:2012年86-7]
- Hepatitis C virus glycoprotein E2 contains 18 conserved cysteines predicted to form nine disulfide pairs. In this study, a comprehensive cysteine-alanine mutagenesis scan of all 18 cysteine residues was performed in E1E2...
- The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets
[作者:Schrauwen, EJA; Herfst, S; Leijten, LM; van Run, P; Bestebroer, TM; Linster, M; Bodewes, R; Kreijtz, JHCM; Rimmelzwaan, GF; Osterhaus, ADME; Fouchier, RAM; Kuiken, T; van Riel, D,期刊:Journal of virology, 页码:3975-3984 , 文章类型: Article,,卷期:2012年86-7]
- The route by which highly pathogenic avian influenza (HPAI) H5N1 virus spreads systemically, including the central nervous system (CNS), is largely unknown in mammals. Especially, the olfactory route, which could be a ro...
- Analysis of the Autographa californica Multiple Nucleopolyhedrovirus Overlapping Gene Pair lef3 and ac68 Reveals that AC68 Is a Per Os Infectivity Factor and that LEF3 Is Critical, but Not Essential, for Virus Replication
[作者:Nie, YC; Fang, MG; Erlandson, MA; Theilmann, DA,期刊:Journal of virology, 页码:3985-3994 , 文章类型: Article,,卷期:2012年86-7]
- Autographa californica multiple nucleopolyhedrovirus ac68 is a core gene that overlaps lef3 which encodes the single-stranded DNA binding protein. A knockout (KO) virus lacking both lef3 and ac68 was generated (lef3-ac68...
- HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes
[作者:Tong, T; Crooks, ET; Osawa, K; Binley, JM,期刊:Journal of virology, 页码:3574-3587 , 文章类型: Article,,卷期:2012年86-7]
- Hypothetically, since native HIV-1 Env trimers are exclusively recognized by neutralizing antibodies, they might induce the neutralizing antibodies in a vaccine setting. This idea has not been evaluated due to the diffic...
- Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus
[作者:Woo, PCY; Lau, SKP; Lam, CSF; Lau, CCY; Tsang, AKL; Lau, JHN; Bai, R; Teng, JLL; Tsang, CCC; Wang, M; Zheng, BJ; Chan, KH; Yuen, KY,期刊:Journal of virology, 页码:3995-4008 , 文章类型: Article,,卷期:2012年86-7]
- Recently, we reported the discovery of three novel coronaviruses, bulbul coronavirus HKU11, thrush coronavirus HKU12, and munia coronavirus HKU13, which were identified as representatives of a novel genus, Deltacoronavir...
- HLA B(star)5701-Positive Long-Term Nonprogressors/Elite Controllers Are Not Distinguished from Progressors by the Clonal Composition of HIV-Specific CD8(+) T Cells
[作者:Mendoza, D; Royce, C; Ruff, LE; Ambrozak, DR; Quigley, MF; Dang, T; Venturi, V; Price, DA; Douek, DC; Migueles, SA; Connors, M,期刊:Journal of virology, 页码:4014-4018 , 文章类型: Article,,卷期:2012年86-7]
- To better understand the qualitative features of effective human immunodeficiency virus (HIV)-specific immunity, we examined the TCR clonal composition of CD8(+) T cells recognizing conserved HIV p24-derived epitopes in ...
- Recombinant Dengue Type 2 Viruses with Altered E Protein Domain III Epitopes Are Efficiently Neutralized by Human Immune Sera
[作者:Wahala, WMPB; Huang, C; Butrapet, S; White, LJ; de Silva, AM,期刊:Journal of virology, 页码:4019-4023 , 文章类型: Article,,卷期:2012年86-7]
- Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection. Many mouse antibodies that neutralize DENV bind to the lateral ridge or A strand epitopes on domain III of...
- An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
[作者:Helguera, G; Jemielity, S; Abraham, J; Cordo, SM; Martinez, MG; Rodriguez, JA; Bregni, C; Wang, JYZJ; Farzan, M; Penichet, ML; Candurra, NA; Choe, H,期刊:Journal of virology, 页码:4024-4028 , 文章类型: Article,,卷期:2012年86-7]
- Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus,...
- The 3A Protein from Multiple Picornaviruses Utilizes the Golgi Adaptor Protein ACBD3 To Recruit PI4KIII beta
[作者:Greninger, AL; Knudsen, GM; Betegon, M; Burlingame, AL; DeRisi, JL,期刊:Journal of virology, 页码:3605-3616 , 文章类型: Article,,卷期:2012年86-7]
- The activity of phosphatidylinositol 4-kinase class III beta (PI4KIII beta) has been shown to be required for the replication of multiple picornaviruses; however, it is unclear whether a physical association between PI4K...
- The Genome Sequence of the Emerging Common Midwife Toad Virus Identifies an Evolutionary Intermediate within Ranaviruses
[作者:Mavian, C; Lopez-Bueno, A; Balseiro, A; Casais, R; Alcami, A; Alejo, A,期刊:Journal of virology, 页码:3617-3625 , 文章类型: Article,,卷期:2012年86-7]
- Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors directly related to human activities. These factors may additionally be favoring the emergence ...
- Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Human Varicella-Zoster Virus
[作者:Willer, DO; Ambagala, APN; Pilon, R; Chan, JK; Fournier, J; Brooks, J; Sandstrom, P; MacDonald, KS,期刊:Journal of virology, 页码:3626-3634 , 文章类型: Article,,卷期:2012年86-7]
- Varicella-zoster virus (VZV) is a member of the alphaherpesvirus family and the causative agent of chickenpox and shingles. To determine the utility of cynomolgus macaques (Macaca fascicularis) as a nonhuman primate mode...
- Depletion of Intracellular Zinc Inhibits the Ubiquitin Ligase Activity of Viral Regulatory Protein ICP0 and Restricts Herpes Simplex Virus 1 Replication in Cell Culture
[作者:Grant, K; Grant, L; Tong, L; Boutell, C,期刊:Journal of virology, 页码:4029-4033 , 文章类型: Article,,卷期:2012年86-7]
- The viral ubiquitin ligase ICP0 stimulates the onset of HSV-1 lytic infection and productive reactivation of viral genomes from latency. In order to mediate these processes, it requires its C3HC4 RING finger domain, a te...
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