- Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance
[作者:Conrad, JA; Ramalingam, RK; Duncan, CB; Smith, RM; Wei, J; Barnett, L; Simons, BC; Lorey, SL; Kalams, SA,期刊:Journal of virology, 页码:4213-4221 , 文章类型: Article,,卷期:2012年86-8]
- After initiation of antiretroviral therapy (ART), HIV loads and frequencies of HIV epitope-specific immune responses decrease. A diverse virus-specific T cell receptor (TCR) repertoire allows the host to respond to viral...
- The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon
[作者:Alvarez-Breckenridge, CA; Yu, JH; Price, R; Wei, M; Wang, Y; Nowicki, MO; Ha, YP; Bergin, S; Hwang, C; Fernandez, SA; Kaur, B; Caligiuri, MA; Chiocca, EA,期刊:Journal of virology, 页码:4566-4577 , 文章类型: Article,,卷期:2012年86-8]
- Tumor virotherapy has been and continues to be used in clinical trials. One barrier to effective viral oncolysis, consisting of the interferon (IFN) response induced by viral infection, is inhibited by valproic acid (VPA...
- The PI3K/Akt Pathway Contributes to Arenavirus Budding
[作者:Urata, S; Ngo, N; de la Torre, JC,期刊:Journal of virology, 页码:4578-4585 , 文章类型: Article,,卷期:2012年86-8]
- Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that ...
- Live Attenuated Herpes Simplex Virus 2 Glycoprotein E Deletion Mutant as a Vaccine Candidate Defective in Neuronal Spread
[作者:Awasthi, S; Zumbrun, EE; Si, HX; Wang, FS; Shaw, CE; Cai, M; Lubinski, JM; Barrett, SM; Balliet, JW; Flynn, JA; Casimiro, DR; Bryan, JT; Friedman, HM,期刊:Journal of virology, 页码:4586-4598 , 文章类型: Article,,卷期:2012年86-8]
- A herpes simplex virus 2 (HSV-2) glycoprotein E deletion mutant (gE2-del virus) was evaluated as a replication-competent, attenuated live virus vaccine candidate. The gE2-del virus is defective in epithelial cell-to-axon...
- Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus
[作者:Miller, MS; Pelka, P; Fonseca, GJ; Cohen, MJ; Kelly, JN; Barr, SD; Grand, RJA; Turnell, AS; Whyte, P; Mymryk, JS,期刊:Journal of virology, 页码:4222-4233 , 文章类型: Article,,卷期:2012年86-8]
- Early region 1A (E1A) of human adenovirus (HAdV) has been the focus of over 30 years of investigation and is required for the oncogenic capacity of HAdV in rodents. Alternative splicing of the E1A transcript generates mR...
- Primary Severe Acute Respiratory Syndrome Coronavirus Infection Limits Replication but Not Lung Inflammation upon Homologous Rechallenge
[作者:Clay, C; Donart, N; Fomukong, N; Knight, JB; Lei, WL; Price, L; Hahn, F; Van Westrienen, J; Harrod, KS,期刊:Journal of virology, 页码:4234-4244 , 文章类型: Article,,卷期:2012年86-8]
- Our knowledge regarding immune-protective and immunopathogenic events in severe acute respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about the dynamics of the immune response at the...
- Plasmacytoid Dendritic Cells Reduce HIV Production in Elite Controllers
[作者:Machmach, K; Leal, M; Gras, C; Viciana, P; Genebat, M; Franco, E; Boufassa, F; Lambotte, O; Herbeuval, JP; Ruiz-Mateos, E,期刊:Journal of virology, 页码:4245-4252 , 文章类型: Article,,卷期:2012年86-8]
- HIV elite controllers (EC) are a rare group of HIV-infected patients who are able to maintain undetectable viral loads during a long period of time in the absence of antiretroviral treatment. Adaptive immunity and host g...
- Anti-HIV-1 Activity of Elafin Is More Potent than Its Precursor's, Trappin-2, in Genital Epithelial Cells
[作者:Drannik, AG; Nag, K; Yao, XD; Henrick, BM; Jain, S; Ball, B; Plummer, FA; Wachihi, C; Kimani, J; Rosenthal, KL,期刊:Journal of virology, 页码:4599-4610 , 文章类型: Article,,卷期:2012年86-8]
- Cervicovaginal lavage fluid (CVL) is a natural source of anti-HIV-1 factors; however, molecular characterization of the anti-HIV-1 activity of CVL remains elusive. In this study, we confirmed that CVLs from HIV-1-resista...
- Metagenomic Analysis of Viruses from Bat Fecal Samples Reveals Many Novel Viruses in Insectivorous Bats in China
[作者:Ge, XY; Li, Y; Yang, XL; Zhang, HJ; Zhou, P; Zhang, YZ; Shi, ZL,期刊:Journal of virology, 页码:4620-4630 , 文章类型: Article,,卷期:2012年86-8]
- Increasing data indicate that bats harbor diverse viruses, some of which cause severe human diseases. In this study, sequence-independent amplification and high-throughput sequencing (Solexa) were applied to the metageno...
- The Immune Response to a Vesicular Stomatitis Virus Vaccine Vector Is Independent of Particulate Antigen Secretion and Protein Turnover Rate
[作者:Cobleigh, MA; Bradfield, C; Liu, YJ; Mehta, A; Robek, MD,期刊:Journal of virology, 页码:4253-4261 , 文章类型: Article,,卷期:2012年86-8]
- Vesicular stomatitis virus (VSV) is a highly cytopathic virus being developed as a vaccine vector due to its ability to induce strong protective T cell and antibody responses after a single dose. However, little is known...
- Functional Hierarchy of Herpes Simplex Virus 1 Viral Glycoproteins in Cytoplasmic Virion Envelopment and Egress
[作者:Chouljenko, DV; Kim, IJ; Chouljenko, VN; Subramanian, R; Walker, JD; Kousoulas, KG,期刊:Journal of virology, 页码:4262-4270 , 文章类型: Article,,卷期:2012年86-8]
- Herpes simplex virus 1 (HSV-1) viral glycoproteins gD (carboxyl terminus), gE, gK, and gM, the membrane protein UL20, and membrane-associated protein UL11 play important roles in cytoplasmic virion envelopment and egress...
- Genetic Evidence of a Long-Range RNA-RNA Interaction between the Genomic 5 ' Untranslated Region and the Nonstructural Protein 1 Coding Region in Murine and Bovine Coronaviruses
[作者:Guan, BJ; Su, YP; Wu, HY; Brian, DA,期刊:Journal of virology, 页码:4631-4643 , 文章类型: Article,,卷期:2012年86-8]
- Higher-order RNA structures in the 5' untranslated regions (UTRs) of the mouse hepatitis coronavirus (MHV) and bovine coronavirus (BCoV), separate species in the betacoronavirus genus, appear to be largely conserved desp...
- Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Recombinant Priming and Envelope Protein Boosting Elicits Localized, Mucosal IgA Immunity in Rhesus Macaques Correlated with Delayed Acquisition following a Repeated Low-Dose Rectal SIVmac251 Challenge
[作者:Xiao, P; Patterson, LJ; Kuate, S; Brocca-Cofano, E; Thomas, MA; Venzon, D; Zhao, J; DiPasquale, J; Fenizia, C; Lee, EM; Kalisz, I; Kalyanaraman, VS; Pal, R; Montefiori, D; Keele, BF; Robert-Guroff, M,期刊:Journal of virology, 页码:4644-4657 , 文章类型: Article,,卷期:2012年86-8]
- We have shown that sequential replicating adenovirus type 5 host range mutant human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) recombinant priming delivered first intranasally (i.n.) plus orally and t...
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