- Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC
[作者:Zuo, T; Liu, DL; Lv, W; Wang, XD; Wang, JW; Lv, MY; Huang, WL; Wu, JX; Zhang, HH; Jin, HW; Zhang, LR; Kong, W; Yu, XH,期刊:Journal of virology, 页码:5497-5507 , 文章类型: Article,,卷期:2012年86-10]
- The HIV-1 viral infectivity factor (Vif) protein is essential for viral replication. Vif recruits cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein APOBEC3G (A3G) for proteasomal degrad...
- The Magnitude of Dengue Virus NS1 Protein Secretion Is Strain Dependent and Does Not Correlate with Severe Pathologies in the Mouse Infection Model
[作者:Watanabe, S; Tan, KH; Rathore, APS; Rozen-Gagnon, K; Shuai, W; Ruedl, C; Vasudevan, SG,期刊:Journal of virology, 页码:5508-5514 , 文章类型: Article,,卷期:2012年86-10]
- There are conflicting data on the relationship between the level of secreted NS1 (sNS1), viremia, and disease severity upon dengue virus (DENY) infection in the clinical setting, and therefore, we examined this relations...
- Influenza Virus H1N1pdm09 Infections in the Young and Old: Evidence of Greater Antibody Diversity and Affinity for the Hemagglutinin Globular Head Domain (HA1 Domain) in the Elderly than in Young Adults and Children
[作者:Verma, N; Dimitrova, M; Carter, DM; Crevar, CJ; Ross, TM; Golding, H; Khurana, S,期刊:Journal of virology, 页码:5515-5522 , 文章类型: Article,,卷期:2012年86-10]
- The H1N1 2009 influenza virus (H1N1pdm09) pandemic had several unexpected features, including low morbidity and mortality in older populations. We performed in-depth evaluation of antibody responses generated following H...
- Restored PB1-F2 in the 2009 Pandemic H1N1 Influenza Virus Has Minimal Effects in Swine
[作者:Pena, L; Vincent, AL; Loving, CL; Henningson, JN; Lager, KM; Lorusso, A; Perez, DR,期刊:Journal of virology, 页码:5523-5532 , 文章类型: Article,,卷期:2012年86-10]
- PB1-F2 is an 87- to 90-amino-acid-long protein expressed by certain influenza A viruses. Previous studies have shown that PB1-F2 contributes to virulence in the mouse model; however, its role in natural hosts-pigs, human...
- Shelterin Dysfunction and p16(INK4a)-Mediated Growth Inhibition in HIV-1-Specific CD8 T Cells
[作者:Lichterfeld, M; Cung, T; Seiss, K; Rosenberg, ES; Pereyra, F; Yu, XG,期刊:Journal of virology, 页码:5533-5540 , 文章类型: Article,,卷期:2012年86-10]
- HIV-1-specific cytotoxic T cell responses are expanded during advanced HIV-1 infection but seem unable to effectively protect the host against disease progression. These cells are able to produce gamma interferon and rem...
- Valosin-Containing Protein (VCP/p97) Is Required for Poliovirus Replication and Is Involved in Cellular Protein Secretion Pathway in Poliovirus Infection
[作者:Arita, M; Wakita, T; Shimizu, H,期刊:Journal of virology, 页码:5541-5553 , 文章类型: Article,,卷期:2012年86-10]
- Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), includ...
- Computational Reconstruction of Bole1a, a Representative Synthetic Hepatitis C Virus Subtype 1a Genome
[作者:Munshaw, S; Bailey, JR; Liu, L; Osburn, WO; Burke, KP; Cox, AL; Ray, SC,期刊:Journal of virology, 页码:5915-5921 , 文章类型: Article,,卷期:2012年86-10]
- Hepatitis C virus (HCV) research is hampered by the use of arbitrary representative isolates in cell culture and immunology. The most replicative isolate in vitro is a subtype 2a virus (JFH-1); however, genotype 1 is mor...
- Abortive Replication of Influenza Virus in Mouse Dendritic Cells
[作者:Ioannidis, LJ; Verity, EE; Crawford, S; Rockman, SP; Brown, LE,期刊:Journal of virology, 页码:5922-5925 , 文章类型: Article,,卷期:2012年86-10]
- The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome...
- Recombinant Influenza A Viruses with Enhanced Levels of PB1 and PA Viral Protein Expression
[作者:Belicha-Villanueva, A; Rodriguez-Madoz, JR; Maamary, J; Baum, A; Bernal-Rubio, D; de la Escalera, MM; Fernandez-Sesma, A; Garcia-Sastre, A,期刊:Journal of virology, 页码:5926-5930 , 文章类型: Article,,卷期:2012年86-10]
- Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replicati...
- TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core
[作者:Valle-Casuso, JC; Di Nunzio, F; Yang, Y; Reszka, N; Lienlaf, M; Arhel, N; Perez, P; Brass, AL; Diaz-Griffero, F,期刊:Journal of virology, 页码:5931-5936 , 文章类型: Article,,卷期:2012年86-10]
- TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 i...
- Four Amino Acids of an Insect Densovirus Capsid Determine Midgut Tropism and Virulence
[作者:Multeau, C; Froissart, R; Perrin, A; Castelli, I; Casartelli, M; Ogliastro, M,期刊:Journal of virology, 页码:5937-5941 , 文章类型: Article,,卷期:2012年86-10]
- Densoviruses are insect parvoviruses that are orally infectious for Lepidoptera. To assess the mechanisms underlying their specificity and their virulence, we investigated the role of eight candidate residues in the dens...
- Analysis of Clinical Ostreid Herpesvirus 1 (Malacoherpesviridae) Specimens by Sequencing Amplified Fragments from Three Virus Genome Areas
[作者:Renault, T; Moreau, P; Faury, N; Pepin, JF; Segarra, A; Webb, S,期刊:Journal of virology, 页码:5942-5947 , 文章类型: Article,,卷期:2012年86-10]
- Although there are a number of ostreid herpesvirus 1 (OsHV-1) variants, it is expected that the true diversity of this virus will be known only after the analysis of significantly more data. To this end, we analyzed 72 O...
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