- Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection
[作者:Zeng, H; Pappas, C; Belser, JA; Houser, KV; Zhong, WM; Wadford, DA; Stevens, T; Balczon, R; Katz, JM; Tumpey, TM,期刊:Journal of virology, 页码:667-678 , 文章类型: Article,,卷期:2012年86-2]
- Highly pathogenic avian influenza (HPAI) H5N1 viruses continue to cause sporadic human infections with a high fatality rate. Respiratory failure due to acute respiratory distress syndrome (ARDS) is a complication among h...
- Conserved Glycine 33 Residue in Flexible Domain I of Hepatitis C Virus Core Protein Is Critical for Virus Infectivity
[作者:Angus, AGN; Loquet, A; Stack, SJ; Dalrymple, D; Gatherer, D; Penin, F; Patel, AH,期刊:Journal of virology, 页码:679-690 , 文章类型: Article,,卷期:2012年86-2]
- Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1...
- Ex Vivo and In Vivo Inhibition of Human Rhinovirus Replication by a New Pseudosubstrate of Viral 2A Protease
[作者:Falah, N; Violot, S; Decimo, D; Berri, F; Foucault-Grunenwald, ML; Ohlmann, T; Schuffenecker, I; Morfin, F; Lina, B; Riteau, B; Cortay, JC,期刊:Journal of virology, 页码:691-704 , 文章类型: Article,,卷期:2012年86-2]
- Human rhinoviruses (HRVs) remain a significant public health problem as they are the major cause of both upper and lower respiratory tract infections. Unfortunately, to date no vaccine or antiviral against these pathogen...
- Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2
[作者:Liniger, M; Summerfield, A; Zimmer, G; McCullough, KC; Ruggli, N,期刊:Journal of virology, 页码:705-717 , 文章类型: Article,,卷期:2012年86-2]
- Avian influenza viruses (AIV) raise worldwide veterinary and public health concerns due to their potential for zoonotic transmission. While infection with highly pathogenic AIV results in high mortality in chickens, this...
- Durable Protection from Vaginal Simian-Human Immunodeficiency Virus Infection in Macaques by Tenofovir Gel and Its Relationship to Drug Levels in Tissue
[作者:Dobard, C; Sharma, S; Martin, A; Pau, CP; Holder, A; Kuklenyik, Z; Lipscomb, J; Hanson, DL; Smith, J; Novembre, FJ; Garcia-Lerma, JG; Heneine, W,期刊:Journal of virology, 页码:718-725 , 文章类型: Article,,卷期:2012年86-2]
- A vaginal gel containing 1% tenofovir (TFV) was found to be safe and effective in reducing HIV infection in women when used pericoitally. Because of the long intracellular half-life of TFV and high drug exposure in vagin...
- I kappa B Kinase epsilon-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis
[作者:Nakhaei, P; Sun, Q; Solis, M; Mesplede, T; Bonneil, E; Paz, S; Lin, RT; Hiscott, J,期刊:Journal of virology, 页码:726-737 , 文章类型: Article,,卷期:2012年86-2]
- X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase 3-, 7-, and 9-dependent apoptotic activities that functions as an E3 ubiquitin ligase, and it targets caspases for degradation. In this study, we d...
- Escape from a Dominant HLA-B*15-Restricted CD8(+) T Cell Response against Hepatitis C Virus Requires Compensatory Mutations outside the Epitope
[作者:Ruhl, M; Chhatwal, P; Strathmann, H; Kuntzen, T; Bankwitz, D; Skibbe, K; Walker, A; Heinemann, FM; Horn, PA; Allen, TM; Hoffmann, D; Pietschmann, T; Timm, J,期刊:Journal of virology, 页码:991-1000 , 文章类型: Article,,卷期:2012年86-2]
- Antiviral CD8(+) T cells are a key component of the adaptive immune system against hepatitis C virus (HCV). For the development of immune therapies, it is essential to understand how CD8(+) T cells contribute to clearanc...
- Impact of Vaccination on Cytotoxic T Lymphocyte Immunodominance and Cooperation against Simian Immunodeficiency Virus Replication in Rhesus Macaques
[作者:Ishii, H; Kawada, M; Tsukamoto, T; Yamamoto, H; Matsuoka, S; Shiino, T; Takeda, A; Inoue, M; Iida, A; Hara, H; Shu, T; Hasegawa, M; Naruse, TK; Kimura, A; Takiguchi, M; Matano, T,期刊:Journal of virology, 页码:738-745 , 文章类型: Article,,卷期:2012年86-2]
- Cytotoxic T lymphocyte (CTL) responses play a central role in viral suppression in human immunodeficiency virus (HIV) infections. Prophylactic vaccination resulting in effective CTL responses after viral exposure would c...
- Crystallographic Analysis Reveals Octamerization of Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus
[作者:Akita, F; Higashiura, A; Shimizu, T; Pu, YY; Suzuki, M; Uehara-Ichiki, T; Sasaya, T; Kanamaru, S; Arisaka, F; Tsukihara, T; Nakagawa, A; Omura, T,期刊:Journal of virology, 页码:746-756 , 文章类型: Article,,卷期:2012年86-2]
- The P9-1 protein of Rice black streaked dwarf virus accumulates in viroplasm inclusions, which are structures that appear to play an important role in viral morphogenesis and are commonly found in viruses in the family R...
- Arterivirus and Nairovirus Ovarian Tumor Domain-Containing Deubiquitinases Target Activated RIG-I To Control Innate Immune Signaling
[作者:van Kasteren, PB; Beugeling, C; Ninaber, DK; Frias-Staheli, N; van Boheemen, S; Garcia-Sastre, A; Snijder, EJ; Kikkert, M,期刊:Journal of virology, 页码:773-785 , 文章类型: Article,,卷期:2012年86-2]
- The innate immune response constitutes the first line of defense against viral infection and is extensively regulated through ubiquitination. The removal of ubiquitin from innate immunity signaling factors by deubiquitin...
- RNA Interference against Animal Viruses: How Morbilliviruses Generate Extended Diversity To Escape Small Interfering RNA Control
[作者:Holz, CL; Albina, E; Minet, C; Lancelot, R; Kwiatek, O; Libeau, G; de Almeida, RS,期刊:Journal of virology, 页码:786-795 , 文章类型: Article,,卷期:2012年86-2]
- Viruses are serious threats to human and animal health. Vaccines can prevent viral diseases, but few antiviral treatments are available to control evolving infections. Among new antiviral therapies, RNA interference (RNA...
- Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples
[作者:Ranganathan, P; Clark, PA; Kuo, JS; Salamat, MS; Kalejta, RF,期刊:Journal of virology, 页码:854-864 , 文章类型: Article,,卷期:2012年86-2]
- Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is...
- Role of Multiple Hosts in the Cross-Species Transmission and Emergence of a Pandemic Parvovirus
[作者:Allison, AB; Harbison, CE; Pagan, I; Stucker, KM; Kaelber, JT; Brown, JD; Ruder, MG; Keel, MK; Dubovi, EJ; Holmes, EC; Parrish, CR,期刊:Journal of virology, 页码:865-872 , 文章类型: Article,,卷期:2012年86-2]
- Understanding the mechanisms of cross-species virus transmission is critical to anticipating emerging infectious diseases. Canine parvovirus type 2 (CPV-2) emerged as a variant of a feline parvovirus when it acquired mut...
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