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  • Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers
    [作者:Finkelman, BS; Rubinstein, WS; Friedman, S; Friebel, TM; Dubitsky, S; Schonberger, NS; Shoretz, R; Singer, CF; Blum, JL; Tung, N; Olopade, OI; Weitzel, JN; Lynch, HT; Snyder, C; Garber, JE; Schildkraut, J; Daly, MB; Isaacs, C; Pichert, G; Neuhausen, SL; Couch, FJ; van't Veer, L; Eeles, R; Bancroft, E; Evans, DG; Ganz, PA; Tomlinson, GE; Narod, SA; Matloff, E; Domchek, S; Rebbeck, TR,期刊:Journal of clinical oncology, 页码:1321-1328 , 文章类型: Article,,卷期:2012年30-12]
  • Purpose Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated ho...