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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共49条记录   Multistep activation of the Helicobacter pylori effector CagA [作者：Muller, A,期刊：Journal of clinical investigation, 页码：1192-1195 , 文章类型： Editorial Material，,卷期：2012年122-4] Chronic infection with the Gram-negative bacterium Helicobacter pylori is a major risk factor for the development of gastric cancer. Accumulating evidence indicates that the H. pylori virulence determinant cytotoxin-asso... Parkinson's disease: don't mess with calcium [作者：Mattson, MP,期刊：Journal of clinical investigation, 页码：1195-1198 , 文章类型： Editorial Material，,卷期：2012年122-4] The hallmark of the movement disorder Parkinson's disease (PD) is progressive degeneration of dopaminergic neurons. Mitochondrial dysfunction, impaired ubiquitin-mediated proteolysis of a-synuclein, and ER stress are eac... A "so cilia" network: cilia proteins start "social" networking [作者：Saudou, F,期刊：Journal of clinical investigation, 页码：1198-1202 , 文章类型： Editorial Material，,卷期：2012年122-4] Cilia are unique cellular organelles found in nearly all cell types. In recent years, the importance of these organelles has been highlighted by the discovery that mutations in genes encoding proteins related to cilia bi... Chk'ing p53-deficient breast cancers [作者：Schoppy, DW; Brown, EJ,期刊：Journal of clinical investigation, 页码：1202-1205 , 文章类型： Editorial Material，,卷期：2012年122-4] Loss or functional impairment of p53 occurs in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Hence, much effort is currently devoted to developing novel treatm... Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease [作者：Gladwin, MT; Kanias, T; Kim-Shapiro, DB,期刊：Journal of clinical investigation, 页码：1205-1208 , 文章类型： Editorial Material，,卷期：2012年122-4] Blood transfusion represents the first and most prescribed cell-based therapy; however, clinical safety and efficacy trials are lacking. Clinical cohort studies have suggested that massive transfusion and/or transfusion ... Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease [作者：Sheikh, F; Ouyang, KF; Campbell, SG; Lyon, RC; Chuang, J; Fitzsimons, D; Tangney, J; Hidalgo, CG; Chung, CS; Cheng, HQ; Dalton, ND; Gu, Y; Kasahara, H; Ghassemian, M; Omens, JH; Peterson, KL; Granzier, HL; Moss, RL; McCulloch, AD; Chen, J,期刊：Journal of clinical investigation, 页码：1209-1221 , 文章类型： Article，,卷期：2012年122-4] Actin-myosin interactions provide the driving force underlying each heartbeat. The current view is that actin-bound regulatory proteins play a dominant role in the activation of calcium-dependent cardiac muscle contracti... MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death [作者：Aurora, AB; Mahmoud, AI; Luo, X; Johnson, BA; van Rooij, E; Matsuzaki, S; Humphries, KM; Hill, JA; Bassel-Duby, R; Sadek, HA; Olson, EN,期刊：Journal of clinical investigation, 页码：1222-1232 , 文章类型： Article，,卷期：2012年122-4] Early reperfusion of ischemic cardiac tissue remains the most effective intervention for improving clinical outcome following myocardial infarction. However, abnormal increases in intracellular Ca2+ during myocardial rep... Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis [作者：Rachel, RA; May-Simera, HL; Veleri, S; Gotoh, N; Choi, BY; Murga-Zamalloa, C; McIntyre, JC; Marek, J; Lopez, I; Hackett, AN; Brooks, M; den Hollander, AI; Beales, PL; Li, TS; Jacobson, SG; Sood, R; Martens, JR; Liu, P; Friedman, TB; Khanna, H; Koenekoop, RK; Kelley, MW; Swaroop, A,期刊：Journal of clinical investigation, 页码：1233-1245 , 文章类型： Article，,卷期：2012年122-4] Cilia are highly specialized microtubule-based organelles that have pivotal roles in numerous biological processes, including transducing sensory signals. Defects in cilia biogenesis and transport cause pleiotropic human... Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma [作者：Howell, GR; Soto, I; Zhu, XJ; Ryan, M; Macalinao, DG; Sousa, GL; Caddle, LB; MacNicoll, KH; Barbay, JM; Porciatti, V; Anderson, MG; Smith, RS; Clark, AF; Libby, RT; John, SWM,期刊：Journal of clinical investigation, 页码：1246-1261 , 文章类型： Article，,卷期：2012年122-4] Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs). Although many studies have implicated various molecul... Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice [作者：Ai, D; Chen, CY; Han, S; Ganda, A; Murphy, AJ; Haeusler, R; Thorp, E; Accili, D; Horton, JD; Tall, AR,期刊：Journal of clinical investigation, 页码：1262-1270 , 文章类型： Article，,卷期：2012年122-4] Individuals with type 2 diabetes have an increased risk of atherosclerosis. One factor underlying this is dyslipidemia, which in hyperinsulinemic subjects with early type 2 diabetes is typically characterized by increase... IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma [作者：Yang, ZZ; Grote, DM; Ziesmer, SC; Niki, T; Hirashima, M; Novak, AJ; Witzig, TE; Ansell, SM,期刊：Journal of clinical investigation, 页码：1271-1282 , 文章类型： Article，,卷期：2012年122-4] The cytolcine IL-12 induces IFN-gamma production by T and NK cells. In preclinical models, it contributes to antitumor immunity. However, in clinical testing, it has shown limited benefit in patients with any one of a va... P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3 [作者：Zerrouqi, A; Pyrzynska, B; Febbraio, M; Brat, DJ; Van Meir, EG,期刊：Journal of clinical investigation, 页码：1283-1295 , 文章类型： Article，,卷期：2012年122-4] Malignant gliomas are the most common and the most lethal primary brain tumors in adults. Among malignant gliomas, 60%-80% show loss of P14ARF tumor suppressor activity due to somatic alterations of the INK4A/ARF genetic... ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis [作者：Worzfeld, T; Swiercz, JM; Looso, M; Straub, BK; Sivaraj, KK; Offermanns, S,期刊：Journal of clinical investigation, 页码：1296-1305 , 文章类型： Article，,卷期：2012年122-4] Diagnosis of metastatic breast cancer is associated with a very poor prognosis. New therapeutic targets are urgently needed, but their development is hampered by a lack of understanding of the mechanisms leading to tumor... PKC epsilon phosphorylation of the sodium channel Na(V)1.8 increases channel function and produces mechanical hyperalgesia in mice [作者：Wu, DF; Chandra, D; McMahon, T; Wang, D; Dadgar, J; Kharazia, VN; Liang, YJ; Waxman, SG; Dib-Hajj, SD; Messing, RO,期刊：Journal of clinical investigation, 页码：1306-1315 , 文章类型： Article，,卷期：2012年122-4] Mechanical hyperalgesia is a common and potentially disabling complication of many inflammatory and neuropathic conditions. Activation of the enzyme PKC epsilon in primary afferent nociceptors is a major mechanism that u... Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline [作者：Talbot, K; Wang, HY; Kazi, H; Han, LY; Bakshi, KP; Stucky, A; Fuino, RL; Kawaguchi, KR; Samoyedny, AJ; Wilson, RS; Arvanitakis, Z; Schneider, JA; Wolf, BA; Bennett, DA; Trojanowski, JQ; Arnold, SE,期刊：Journal of clinical investigation, 页码：1316-1338 , 文章类型： Article，,卷期：2012年122-4] While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder. We provide such a demonstration here by showing that the hippocampal formation (H... An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated A beta oligomers [作者：Bomfim, TR; Forny-Germano, L; Sathler, LB; Brito-Moreira, J; Houzel, JC; Decker, H; Silverman, MA; Kazi, H; Melo, HM; McClean, PL; Holscher, C; Arnold, SE; Talbot, K; Klein, WL; Munoz, DP; Ferreira, ST; De Felice, FG,期刊：Journal of clinical investigation, 页码：1339-1353 , 文章类型： Article，,卷期：2012年122-4] Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection between AD and diabetes has been suggested, a major unknown is...