- Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
[作者：Moiani, A; Paleari, Y; Sartori, D; Mezzadra, R; Miccio, A; Cattoglio, C; Cocchiarella, F; Lidonnici, MR; Ferrari, G; Mavilio, F,期刊：Journal of clinical investigation, 页码：1653-1666 , 文章类型： Article，,卷期：2012年122-5]
- Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene ex...
- Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
[作者：Cesana, D; Sgualdino, J; Rudilosso, L; Merella, S; Naldini, L; Montini, E,期刊：Journal of clinical investigation, 页码：1667-1676 , 文章类型： Article，,卷期：2012年122-5]
- Gamma-retroviral/lentiviral vectors (gamma RV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and internal moderate cellular promoters pose a reduced risk of insertional mutagenesis when compared with vecto...
- Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice
[作者：Ai, D; Baez, JM; Jiang, HF; Conlon, DM; Hernandez-Ono, A; Frank-Kamenetsky, M; Milstein, S; Fitzgerald, K; Murphy, AJ; Woo, CW; Strong, A; Ginsberg, HN; Tabas, I; Rader, DJ; Tall, AR,期刊：Journal of clinical investigation, 页码：1677-1687 , 文章类型： Article，,卷期：2012年122-5]
- Recent GWAS have identified SNPs at a human chromosoml locus associated with coronary artery disease risk and LDL cholesterol levels. The SNPs are also associated with altered expression of hepatic sortilin-1 (SORT1), wh...
- Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
[作者：Takiishi, T; Korf, H; Van Belle, TL; Robert, S; Grieco, FA; Caluwaerts, S; Galleri, L; Spagnuolo, I; Steidler, L; Van Huynegem, K; Demetter, P; Wasserfall, C; Atkinson, MA; Dotta, F; Rottiers, P; Gysemans, C; Mathieu, C,期刊：Journal of clinical investigation, 页码：1717-1725 , 文章类型： Article，,卷期：2012年122-5]
- Current interventions for arresting autoimmune diabetes have yet to strike the balance between sufficient efficacy, minimal side effects, and lack of generalized immunosuppression. Introduction of antigen via the gut rep...
- Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
[作者：Maione, F; Capano, S; Regano, D; Zentilin, L; Giacca, M; Casanovas, O; Bussolino, F; Serini, G; Giraudo, E,期刊：Journal of clinical investigation, 页码：1832-1848 , 文章类型： Article，,卷期：2012年122-5]
- Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to interfere with tumor growth, but cancer cells respond by deve...
- Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
[作者：Celia-Terrassa, T; Meca-Cortes, O; Mateo, F; de Paz, AM; Rubio, N; Arnal-Estape, A; Ell, BJ; Bermudo, R; Diaz, A; Guerra-Rebollo, M; Lozano, JJ; Estaras, C; Ulloa, C; Alvarez-Simon, D; Mila, J; Vilella, R; Paciucci, R; Martinez-Balbas, M; de Herreros, AG; Gomis, RR; Kang, YB; Blanco, J; Fernandez, PL; Thomson, TM,期刊：Journal of clinical investigation, 页码：1849-1868 , 文章类型： Article，,卷期：2012年122-5]
- Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of ...
- Cooperation between Rb and Art in suppressing mouse retinoblastoma
[作者：Conkrite, K; Sundby, M; Mu, D; Mukai, S; MacPherson, D,期刊：Journal of clinical investigation, 页码：1726-1733 , 文章类型： Article，,卷期：2012年122-5]
- Retinoblastoma is a pediatric cancer that has served as a paradigm for tumor suppressor gene function. Retinoblastoma is initiated by RB gene mutations, but the subsequent cooperating mutational events leading to tumorig...
- Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker
[作者：Ray, P; Rialon-Guevara, KL; Veras, E; Sullenger, BA; White, RR,期刊：Journal of clinical investigation, 页码：1734-1741 , 文章类型： Article，,卷期：2012年122-5]
- Most cases of pancreatic cancer are not diagnosed until they are no longer curable with surgery. Therefore, it is critical to develop a sensitive, preferably noninvasive, method for detecting the disease at an earlier st...
- Revertant mosaicism in a human skin fragility disorder results from slipped mispairing and mitotic recombination
[作者：Kiritsi, D; He, YH; Pasmooij, AMG; Onder, M; Happle, R; Jonkman, MF; Bruckner-Tuderman, L; Has, C,期刊：Journal of clinical investigation, 页码：1742-1746 , 文章类型： Article，,卷期：2012年122-5]
- Spontaneous gene repair, also called revertant mosaicism, has been documented in several genetic disorders involving organs that undergo self-regeneration, including the skin. Genetic reversion may occur through differen...
- CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice
[作者：Zanoni, I; Ostuni, R; Barresi, S; Di Gioia, M; Broggi, A; Costa, B; Marzi, R; Granucci, F,期刊：Journal of clinical investigation, 页码：1747-1757 , 文章类型： Article，,卷期：2012年122-5]
- Inflammation is a multistep process triggered when innate immune cells for example, DCs sense a pathogen or injured cell or tissue. Edema formation is one of the first steps in the inflammatory response; it is fundamenta...
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