- Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluorothymidine, a Novel Antitumor Nucleoside, in Rats
[作者:Okayama, T; Yoshisue, K; Kuwata, K; Komuro, M; Ohta, S; Nagayama, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:457-462 , 文章类型: Article,,卷期:2012年340-2]
- alpha alpha alpha-Trifluorothymidine (TFT), an anticancer nucleoside analog, is a potent thymidylate synthase inhibitor. TFT exerts its antitumor activity primarily by inducing DNA fragmentation after incorporation of th...
- Structural Nucleotide Analogs Are Potent Activators/Inhibitors of Pancreatic beta Cell KATP Channels: An Emerging Mechanism Supporting Their Use as Antidiabetic Drugs
[作者:Tricarico, D; Rolland, JF; Cannone, G; Mele, A; Cippone, V; Laghezza, A; Carbonara, G; Fracchiolla, G; Tortorella, P; Loiodice, F; Camerino, DC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:266-276 , 文章类型: Article,,卷期:2012年340-2]
- The 2H-1,4-benzoxazine derivatives are novel drugs structurally similar to nucleotides; however, their actions on the pancreatic beta cell ATP-sensitive K(+) (KATP) channel and on glucose disposal are unknown. Therefore,...
- Spleen Tyrosine Kinase Mediates BEAS-2B Cell Migration and Proliferation and Human Rhinovirus-Induced Expression of Vascular Endothelial Growth Factor and Interleukin-8
[作者:Wang, XM; Mychajlowycz, M; Lau, C; Gutierrez, C; Scott, JA; Chow, CW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:277-285 , 文章类型: Article,,卷期:2012年340-2]
- Spleen tyrosine kinase (Syk) is an immunoregulatory tyrosine kinase that was identified originally in leukocytes. It is a key regulator of innate immunity as well as hematopoietic cell differentiation and proliferation. ...
- Effects of the alpha(2)-Adrenergic Agonist Clonidine on the Pharmacodynamics and Pharmacokinetics of 3,4-Methylenedioxymethamphetamine in Healthy Volunteers
[作者:Hysek, CM; Brugger, R; Simmler, LD; Bruggisser, M; Donzelli, M; Grouzmann, E; Hoener, MC; Liechti, ME,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:286-294 , 文章类型: Article,,卷期:2012年340-2]
- The mechanism of action of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) involves the carrier-mediated and potentially vesicular release of monoamines. We assessed the effects of the sympatholytic alpha(2)-adrenergic...
- Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis
[作者:Coffey, G; DeGuzman, F; Inagaki, M; Pak, Y; Delaney, SM; Ives, D; Betz, A; Jia, ZJ; Pandey, A; Baker, D; Hollenbach, SJ; Phillips, DR; Sinha, U,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:350-359 , 文章类型: Article,,卷期:2012年340-2]
- Based on genetic studies that establish the role of spleen tyrosine kinase (Syk) in immune function, inhibitors of this kinase are being investigated as therapeutic agents for inflammatory diseases. Because genetic studi...
- Changes in Mouse Liver Protein Glutathionylation after Acetaminophen Exposure
[作者:Yang, X; Greenhaw, J; Ali, A; Shi, Q; Roberts, DW; Hinson, JA; Muskhelishvili, L; Beger, R; Pence, LM; Ando, Y; Sun, JC; Davis, K; Salminen, WF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:360-368 , 文章类型: Article,,卷期:2012年340-2]
- The role of protein glutathionylation in acetaminophen (APAP)induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300 mg/kg APAP in B6C3F1 mice produced increased serum alanine aminotr...
- Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
[作者:Pettipher, R; Vinall, SL; Xue, LZ; Speight, G; Townsend, ER; Gazi, L; Whelan, CJ; Armer, RE; Payton, MA; Hunter, MG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:473-482 , 文章类型: Article,,卷期:2012年340-2]
- D prostanoid receptor 2 (DP(2)) [also known as chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells (CRTH2)] is selectively expressed by Th2 lymphocytes, eosinophils, and basophils and mediate...
- The Effects of TAK-875, a Selective G Protein-Coupled Receptor 40/Free Fatty Acid 1 Agonist, on Insulin and Glucagon Secretion in Isolated Rat and Human Islets
[作者:Yashiro, H; Tsujihata, Y; Takeuchi, K; Hazama, M; Johnson, PRV; Rorsman, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:483-489 , 文章类型: Article,,卷期:2012年340-2]
- G protein-coupled receptor 40 (GPR40)/free fatty acid 1 (FFA1) is a G protein-coupled receptor involved in free fatty acid-induced insulin secretion. To analyze the effect of our novel GPR40/FFA1-selective agonist, [(3S)...
- The Cytochrome P450 4A/F-20-Hydroxyeicosatetraenoic Acid System: A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood (vol 338, pg 421, 2011)
[作者:Guo, AM; Janic, B; Sheng, J; Falck, JR; Roman, RJ; Edwards, PA; Arbab, AS; Scicli, AG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:490-490 , 文章类型: Correction,,卷期:2012年340-2]
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