- Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
[作者:Scannevin, RH; Chollate, S; Jung, MY; Shackett, M; Patel, H; Bista, P; Zeng, WK; Ryan, S; Yamamoto, M; Lukashev, M; Rhodes, KJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:274-284 , 文章类型: Article,,卷期:2012年341-1]
- Oxidative stress is central to the pathology of several neurodegenerative diseases, including multiple sclerosis, and therapeutics designed to enhance antioxidant potential could have clinical value. The objective of thi...
- Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis
[作者:Zhang, L; Qin, X; Zhao, Y; Fast, L; Zhuang, SG; Liu, P; Cheng, GM; Zhao, TC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:285-293 , 文章类型: Article,,卷期:2012年341-1]
- We have previously shown that the inhibition of histone deacetylases (HDACs) protects the heart against acute myocardial ischemia and reperfusion injury. We also demonstrated that HDAC inhibition stimulates myogenesis an...
- Estimation of Drug-Metabolizing Capacity by Cytochrome P450 Genotyping and Expression
[作者:Temesvari, M; Kobori, L; Paulik, J; Sarvary, E; Belic, A; Monostory, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:294-305 , 文章类型: Article,,卷期:2012年341-1]
- Many undesired side effects or therapeutic failures of drugs are the result of differences or changes in drug metabolism, primarily depending on the levels and activities of cytochrome P450 (P450) enzymes. To assess whet...
- Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model
[作者:Menochet, K; Kenworthy, KE; Houston, JB; Galetin, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:2-15 , 文章类型: Article,,卷期:2012年341-1]
- Kinetic parameters describing hepatic uptake in hepatocytes are frequently estimated without appropriate incorporation of bidirectional passive diffusion, intracellular binding, and metabolism. A mechanistic two-compartm...
- Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and Paclitaxel
[作者:Gupta, S; Wulf, G; Henjakovic, M; Koepsell, H; Burckhardt, G; Hagos, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:16-23 , 文章类型: Article,,卷期:2012年341-1]
- Antineoplastic agents directed at nuclear and cytoplasmic targets in tumor cells represent the current mainstay of treatment for patients with disseminated malignant diseases. Cellular uptake of antineoplastics is a prer...
- Blocking Epidermal Growth Factor Receptor Activation by 3,3 '-Diindolylmethane Suppresses Ovarian Tumor Growth In Vitro and In Vivo
[作者:Kandala, PK; Wright, SE; Srivastava, SK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:24-32 , 文章类型: Article,,卷期:2012年341-1]
- Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR) (in approximately 70% of ovarian tumors), play a crucial role in the signal transduction pathways that regulate key cellular fu...
- GABAergic Actions Mediate Opposite Ethanol Effects on Dopaminergic Neurons in the Anterior and Posterior Ventral Tegmental Area
[作者:Guan, YZ; Xiao, C; Krnjevic, K; Xie, GQ; Zuo, WH; Ye, JH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:33-42 , 文章类型: Article,,卷期:2012年341-1]
- It is known that the posterior ventral tegmental area (p-VTA) differs from the anterior VTA (a-VTA) in that rats learn to self-administer ethanol into the p-VTA, but not into the a-VTA. Because activation of VTA dopamine...
- Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating mu-Opioid Receptors
[作者:Xie, GQ; Hipolito, L; Zuo, WH; Polache, A; Granero, L; Krnjevic, K; Ye, JH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:43-50 , 文章类型: Article,,卷期:2012年341-1]
- Previous studies in vivo have shown that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse. Although opioid receptors, especially the mu-opioid recepto...
- RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
[作者:Xu, DG; Kim, Y; Postelnek, J; Vu, MD; Hu, DQ; Liao, C; Bradshaw, M; Hsu, J; Zhang, J; Pashine, A; Srinivasan, D; Woods, J; Levin, A; O'Mahony, A; Owens, TD; Lou, Y; Hill, RJ; Narula, S; DeMartino, J; Fine, JS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:90-103 , 文章类型: Article,,卷期:2012年341-1]
- Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale for the development of ...
- P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Restrict Brain Accumulation of the Active Sunitinib Metabolite N-Desethyl Sunitinib
[作者:Tang, SC; Lankheet, NAG; Poller, B; Wagenaar, E; Beijnen, JH; Schinkel, AH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:164-173 , 文章类型: Article,,卷期:2012年341-1]
- N-desethyl sunitinib is a major and pharmacologically active metabolite of the tyrosine kinase inhibitor and anticancer drug sunitinib. Because the combination of N-desethyl sunitinib and sunitinib represents total activ...
- Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis
[作者:Verbrugge, SE; Assaraf, YG; Dijkmans, BAC; Scheffer, GL; Al, M; den Uyl, D; Oerlemans, R; Chan, ET; Kirk, CJ; Peters, GJ; Van der Heijden, JW; de Gruijl, TD; Scheper, RJ; Jansen, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:174-182 , 文章类型: Article,,卷期:2012年341-1]
- Bortezomib (BTZ), a registered proteasome inhibitor (PI) for multiple myeloma, has also been proposed as a potential antirheumatic agent. Its reported side effects, however, make it unappealing for long-term administrati...
- Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy
[作者:Xu, XM; Chen, K; Kobayashi, S; Timm, D; Liang, QR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:183-195 , 文章类型: Article,,卷期:2012年341-1]
- Resveratrol is a plant-derived polyphenol that can attenuate the cardiotoxic effects of doxorubicin (DOX), a powerful antibiotic widely used in cancer chemotherapy. However, the underlying protective mechanisms of resver...
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