- Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities
[作者:Joe, Y; Zheng, M; Kim, HJ; Kim, S; Uddin, MJ; Park, C; Ryu, DG; Kang, SS; Ryoo, S; Ryter, SW; Chang, KC; Chung, HT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:850-858 , 文章类型: Article,,卷期:2012年341-3]
- Salvia miltiorrhiza (Danshen), a traditional Chinese herbal medicine, is commonly used for the prevention and treatment of cardiovascular disorders including atherosclerosis. However, the mechanisms responsible for the v...
- ABT-737 Synergizes with Bortezomib to Induce Apoptosis, Mediated by Bid Cleavage, Bax Activation, and Mitochondrial Dysfunction in an Akt-Dependent Context in Malignant Human Glioma Cell Lines
[作者:Premkumar, DR; Jane, EP; DiDomenico, JD; Vukmer, NA; Agostino, NR; Pollack, IF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:859-872 , 文章类型: Article,,卷期:2012年341-3]
- We observed that glioma cells are differentially sensitive to N-{4-[4-(4'-chloro-biphenyl-2-ylmethyl)-piperazin-1-yl]-benzoyl}-4-(3-dimethylamino-1-phenylsulfanylmethyl-propylamino)3-nitro-benzenesulfonamide (ABT-737) an...
- Pituitary Adenylate Cyclase-Activating Polypeptide Causes Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor in Lung Cancer Cells
[作者:Moody, TW; Osefo, N; Nuche-Berenguer, B; Ridnour, L; Wink, D; Jensen, RT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:873-881 , 文章类型: Article,,卷期:2012年341-3]
- Pituitary adenylate cyclase-activating polypeptide (PACAP) is an autocrine growth factor for some lung cancer cells. The activated PACAP receptor (PAC1) causes phosphatidylinositol turnover, elevates cAMP, and increases ...
- Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Whether Nanomolar Potency Should Be Required of Candidate Agents
[作者:Wong, CC; Cheng, KW; Rigas, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:572-578 , 文章类型: Article,,卷期:2012年341-3]
- In the current paradigm of anticancer drug development, candidate compounds are evaluated by testing their in vitro potency against molecular targets relevant to carcinogenesis, their effect on cultured cancer cells, and...
- The 5-Hydroxytryptamine(4) Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal theta Oscillations
[作者:Johnson, DE; Drummond, E; Grimwood, S; Sawant-Basak, A; Miller, E; Tseng, E; McDowell, LL; Vanase-Frawley, MA; Fisher, KE; Rubitski, DM; Stutzman-Engwall, KJ; Nelson, RT; Horner, WE; Gorczyca, RR; Hajos, M; Siok, CJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:681-691 , 文章类型: Article,,卷期:2012年341-3]
- 5-Hydroxytryptamine (5-HT)(4) receptor agonists reportedly stimulate brain acetylcholine (ACh) release, a property that might provide a new pharmacological approach for treating cognitive deficits associated with Alzheim...
- Tofogliflozin, a Potent and Highly Specific Sodium/Glucose Cotransporter 2 Inhibitor, Improves Glycemic Control in Diabetic Rats and Mice
[作者:Suzuki, M; Honda, K; Fukazawa, M; Ozawa, K; Hagita, H; Kawai, T; Takeda, M; Yata, T; Kawai, M; Fukuzawa, T; Kobayashi, T; Sato, T; Kawabe, Y; Ikeda, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:692-701 , 文章类型: Article,,卷期:2012年341-3]
- Sodium/glucose cotransporter 2 (SGLT2) is the predominant mediator of renal glucose reabsorption and is an emerging molecular target for the treatment of diabetes. We identified a novel potent and selective SGLT2 inhibit...
- Role of A(2B) Adenosine Receptors in Regulation of Paracrine Functions of Stem Cell Antigen 1-Positive Cardiac Stromal Cells
[作者:Ryzhov, S; Goldstein, AE; Novitskiy, SV; Blackburn, MR; Biaggioni, I; Feoktistov, I,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:764-774 , 文章类型: Article,,卷期:2012年341-3]
- The existence of multipotent cardiac stromal cells expressing stem cell antigen (Sca)-1 has been reported, and their proangiogenic properties have been demonstrated in myocardial infarction models. In this study, we test...
- Pharmacologic Properties of Polyethylene Glycol-Modified Bacillus thiaminolyticus Thiaminase I Enzyme
[作者:Liu, SQ; Bae, Y; Leggas, M; Daily, A; Bhatnagar, S; Miriyala, S; St Clair, DK; Moscow, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:775-783 , 文章类型: Article,,卷期:2012年341-3]
- We have previously shown that the bacterial enzyme thiaminase 1 has antitumor activity. In an attempt to make thiaminase I a more effective pharmaceutical agent, we have modified it by adding polyethylene glycol (PEG) ch...
- Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
[作者:El-Ghaiesh, S; Monshi, MM; Whitaker, P; Jenkins, R; Meng, XL; Farrell, J; Elsheikh, A; Peckham, D; French, N; Pirmohamed, M; Park, BK; Naisbitt, DJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:597-610 , 文章类型: Article,,卷期:2012年341-3]
- beta-Lactam antibiotics provide the cornerstone of treatment and reduce the rate of decline in lung function in patients with cystic fibrosis, but their use is limited by a high frequency of delayed-type allergic reactio...
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