Various fullerene-based electron acceptor materials for organic photovoltaic applications were prepared via [3 + 2] and [4 + 2] cycloadditions using a continuous flow approach. The 1,3-dipolar cycloaddition of the tosylh...
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from D-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and s...
The unusual reactivity of carborane mono- and dialdehydes with pyrroles in the presence of acid catalysts leads to the formation of a new class of carboranyl mono- and dipyrro derivatives.
A concise total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C is reported using a 1,4-addition-aldol condensation-ring-dosing metathesis (RCM) strategy. Initial biological studies indicate that ps...
A two-step procedure for deprotection of alkylpinacolyl boronate esters via transesterification with diethanolamine followed by hydrolysis was successfully developed with the advantages of tolerance to various functional...
To develop oligonucleotides containing new 2'-O-modified ribonucleosides as nucleic acid drugs, we synthesized three types of ribonucleoside derivatives modified at the 2'-hydroxyl group with 2-(methoxycarbonyl)ethyl (MO...
2-(2-Chloroaroyl)methyleneimidazolidines with four reactive sites show fascinating structural features and could be used as a new strategy for the synthesis of novel heterocycles. This paper presents our new findings in ...
We report the synthesis of first examples of BF2 and B(OR)(2) complexes of oxasmaragdyrin, the expanded core-modified porphyrin, in decent yields under very simple reaction conditions at room temperature. The boron compl...
The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide f...
Replacing the methano (NCH2N) bridgehead with an ethano (NCH2CH2N) bridgehead affects the conformational equilibrium of the Wilcox molecular torsion balance. With a NCH2CH2N bridgehead, the phenyl and the cyclohexyl este...
Enantiomerically enriched alpha-aryl alpha-cyanoacetates and alpha-aryl alpha-acylacetonitriles bearing a benzylic quaternary stereocenter have been readily synthesized by stereoselective reaction of 2-alkyl-2-[2-(p-toly...
The AgOAc/ThioClicicFerrophos complex catalyzed the asymmetric Mannich reaction of glycine Schiff base with N-tosylimines effectively to give a mixture of syn and anti adducts (syn/anti = 60/40-70/30) at high yields with...
The synthesis of multivalent glycoclusters, designed to be compatible with biological systems, is reported. A variety of 1-thio-beta-D-galactosides linked to a terminal triple bond through oligoethyleneglycol chains of v...
Aza-peptides are peptidomimetics in which one or more of the alpha-carbons, bearing the side-chain residues, has been replaced by a nitrogen. These peptidomimetics have been shown to be promising for the generation of dr...
In this paper, the mechanisms of the intermolecular [3 + 2] and [1 + 2] cycloaddition reactions of 1,1/1,3-dipolar pi-delocalized singlet vinylcarbenes, which is. obtained from cyclopropenone, with an electron-deficient ...