The 3,5-dinitrobenzoyl-derived 1-naphthylethyl amide 3 is an attractive CSA for NMR analysis of protected amines. It is readily prepared in a single step and combines practical resolution of diastereomeric complexes due ...
During the course of a study aimed at constructing azaspirocycles from 2,3-dihydro-4-pyridones, an unexpected product was obtained in the SET ring-opening reaction of photocycloadduct 1. Differences in reactivity between...
A CuI-catalyzed direct access to sulfides from disulfides via C-H bond cleavage of di- or trimethoxybenzene is described. The procedure utilizes O-2 as a clean and cheap oxidant. Direct selenation of the C-H bond also to...
This Perspective details a developing research program that emerged from simple plans for achieving the synthesis of tetrahydrofurans from cyclopropanes and C=O pi bonds. Lewis acid catalyzed annulations of malonate-deri...
Aiming at developing inhibitors of mannosyltransferases, the enzymes that participate in the biosynthesis of the cell envelope of Mycobacterium tuberculosis, the synthesis of a range of designed triazole-linked 1,6-oligo...
Havellockate (1) was isolated from the soft coral Sinularia granosa located on the Havellock island in the Indian Ocean. This highly compact and polyoxygenated marine diterpene bears a cis-fused hydrindane core that cont...
It was recently reported that the venerable Newman-Kwart rearrangement (1 -> 2) proceeds via mixed first- and second-order kinetics. Prior to this, the rearrangement had been considered to proceed exclusively via an intr...
We have devised a modular construction of electron-rich alkene derivatives from trichloroethylene (TCE). The three C-Cl bonds of TCE have sufficiently different reactivities that they can be sequentially and selectively ...
Triplet carbenes t-butylpentadiynylidene (t-BuC5H, 1a) and dimethylpentadiynylidene (MeC5Me, 1b) have been produced photochemically from their corresponding diazo compound precursors and studied spectroscopically in cryo...
A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R-1-C C-C-C C-R-2). In light of the marginal stability associated with these simple system...
Oxyanion holes play a major role in catalyzing enzymatic reactions, yet the corresponding energetics is frequently misunderstood. The main problem may be associated with the nontrivial nature of the electrostatic preorga...
A novel route to 2',3'-dideoxy-beta-L-erythro-hexopyranosyl nucleosides equipped with a 1'-(N-6-benzoyl-adenin-9-yl) or a 1'-(thymin-l-yl) moiety has been developed. Synthesis of the enantiopure sugar moiety was carried ...
Despite its very weak central C C bond, the yet-unknown hexafluorobicyclobutane is predicted to be quite robust. Unlike the parent hydrocarbon, which undergoes thermal rearrangement to butadiene, the perfluoro compound w...
Binding motifs observed in the crystal structures of protein carbohydrate complexes, in particular the participation of the isopropyl/isobutyl side chain of valine/leucine in the formation of van der Waals contacts, have...
Base-functionalized aza-bis(oxazoline) ligands were prepared to explore the concept of dual activation through the Lewis acid and a tethered tertiary amine base, The catalytic activity of the Cu complex was evaluated for...
The study of the polyfluorination and polytrifluoromethylation effects on electronic structure and intrinsic acidities has been performed using DFT B3LYP and NBO calculations for the valence isomers of benzene and phenol...