Understanding electronic communication among interacting constituents of multicomponent molecular architectures is important for rational design in diverse fields including artificial photosynthesis and molecular electro...
Fosmidomycin and its analogue FR-900098 are potent inhibitors of 1-deoxy-D-xylulose 5-phosphate reducto-isomerase (DXR), the second enzyme of the MEP pathway for the biosynthesis of isoprenoids. This paper describes the ...
The existence and stability of the aldehyde-hydrate form of imidazole-2-carboxaldehyde (4) were studied using FTIR together with solution- and solid-state NMR experiments. The results allowed us to conclude that the hydr...
Di- and triphosphorylated small molecules represent key intermediates in a wide range of biological and chemical processes. The importance of polyphosphorylated species in biology and medicine underscores the need to dev...
Polyhalogenated 4,4'-bipyridines were conveniently synthesized in a single step starting from dihalo-pyridines. A mechanism was proposed on the basis of experiments performed with 2-chloro-5-bromopyridine I a. 2-Chloro-4...
We have developed a regiospecific and highly stereoselective strategy for constructing the five-/six-membered monocyclic and bicyclic nitrogen heterocycle skeletons using PhSe group transfer radical cyclization of alpha-...
Cultivation of actinomycete strain CNQ-418, retrieved from a deep ocean sediment sample off the coast of La Jolla, CA, has provided marinopyrroles A F. Sharing just 98% 16S rRNA gene sequence identity with S. sannurensis...
Carbanions of aryl 3-chloropropylsulfoxides react with nonenolizable aldehydes to give 2,3-disubstituted tetrahydrofurans. Deprotonation of the sulfoxides carried out in the presence of aldehydes results in the addition ...
Addition of stabilized carbanionic nucleophiles to cyclic vinylouous acyl triflates (VATs) triggers a ring-opening fragmentation to give acyclic beta-keto ester and related products, much like those observed traditionall...
A series of pillar[5]arene derivatives with alkyl groups of different length were synthesized. The new alkyl-substituted pillar[5]arene derivatives 1,4-bis(ethoxy)pillar[S]arene (C2), 1,4-bis(propoxy)pillar[5]arene (C3),...