- Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family
[作者：Garcia, BL; Summers, BJ; Lin, Z; Ramyar, KX; Ricklin, D; Kamath, DV; Fu, ZQ; Lambris, JD; Geisbrecht, BV,期刊：Journal of Biological Chemistry, 页码：628-640 , 文章类型： Article，,卷期：2012年287-1]
- To survive in immune-competent hosts, the pathogen Staphylococcus aureus expresses and secretes a sophisticated array of proteins that inhibit the complement system. Among these are the staphylococcal complement inhibito...
- Wogonin and Related Natural Flavones Overcome Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein Resistance of Tumors by Down-regulation of c-FLIP Protein and Up-regulation of TRAIL Receptor 2 Expression
[作者：Ding, J; Polier, G; Kohler, R; Giaisi, M; Krammer, PH; Li-Weber, M,期刊：Journal of Biological Chemistry, 页码：641-649 , 文章类型： Article，,卷期：2012年287-1]
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent that kills various tumor cells without damaging normal tissues. However, many cancers remain resistant to TRAIL. To overcome...
- Action of Protein Disulfide Isomerase on Proinsulin Exit from Endoplasmic Reticulum of Pancreatic beta-Cells
[作者：Rajpal, G; Schuiki, I; Liu, M; Volchuk, A; Arvan, P,期刊：Journal of Biological Chemistry, 页码：43-47 , 文章类型： Article，,卷期：2012年287-1]
- For insulin synthesis, the proinsulin precursor is translated at the endoplasmic reticulum (ER), folds to include its three native disulfide bonds, and is exported to secretory granules for processing and secretion. Prot...
- Anion Activation Site of Insulin-degrading Enzyme
[作者：Noinaj, N; Song, ES; Bhasin, S; Alper, BJ; Schmidt, WK; Hersh, LB; Rodgers, DW,期刊：Journal of Biological Chemistry, 页码：48-57 , 文章类型： Article，,卷期：2012年287-1]
- Insulin-degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive peptides, including insulin and the amyloid beta peptide. IDE is an unusual metallopeptidase in that it is alloster...
- HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions
[作者：Skasko, M; Wang, Y; Tian, Y; Tokarev, A; Munguia, J; Ruiz, A; Stephens, EB; Opella, SJ; Guatelli, J,期刊：Journal of Biological Chemistry, 页码：58-67 , 文章类型： Article，,卷期：2012年287-1]
- The Vpu protein of HIV-1 antagonizes BST-2 (tetherin), a broad spectrum effector of the innate immune response to viral infection, by an intermolecular interaction that maps genetically to the alpha-helical transmembrane...
- A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation
[作者：Canals, M; Lane, JR; Wen, A; Scammells, PJ; Sexton, PM; Christopoulos, A,期刊：Journal of Biological Chemistry, 页码：650-659 , 文章类型： Article，,卷期：2012年287-1]
- The Monod-Wyman-Changeux (MWC) model was initially proposed to describe the allosteric properties of regulatory enzymes and subsequently extended to receptors. Yet despite GPCRs representing the largest family of recepto...
- Yeast Sterol Regulatory Element-binding Protein (SREBP) Cleavage Requires Cdc48 and Dsc5, a Ubiquitin Regulatory X Domain-containing Subunit of the Golgi Dsc E3 Ligase
[作者：Stewart, EV; Lloyd, SJA; Burg, JS; Nwosu, CC; Lintner, RE; Daza, R; Russ, C; Ponchner, K; Nusbaum, C; Espenshade, PJ,期刊：Journal of Biological Chemistry, 页码：672-681 , 文章类型： Article，,卷期：2012年287-1]
- Schizosaccharomyces pombe Sre1 is a membrane-bound transcription factor that controls adaptation to hypoxia. Like its mammalian homolog, sterol regulatory element-binding protein (SREBP), Sre1 activation requires release...
- Proapoptotic Protein Smac Mediates Apoptosis in Cisplatin-resistant Ovarian Cancer Cells When Treated with the Anti-tumor Agent AT101
[作者：Hu, WB; Wang, F; Tang, JS; Liu, XY; Yuan, Z; Nie, CL; Wei, YQ,期刊：Journal of Biological Chemistry, 页码：68-80 , 文章类型： Article，,卷期：2012年287-1]
- Chemoresistance of ovarian cancer has been previously attributed to the expression and activation of Bcl-2 family proteins. BH3-mimetic molecules possessing potential anticancer activity are able to inhibit antiapoptotic...
- Sulfiredoxin Protein Is Critical for Redox Balance and Survival of Cells Exposed to Low Steady-state Levels of H2O2
[作者：Baek, JY; Han, SH; Sung, SH; Lee, HE; Kim, YM; Noh, H; Bae, SH; Rhee, SG; Chang, TS,期刊：Journal of Biological Chemistry, 页码：81-89 , 文章类型： Article，,卷期：2012年287-1]
- Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins (Prxs). Having high affinity toward H2O2, 2-Cys Prxs can efficiently reduce H2O2 at low concentration...
- Modulation of L-alpha-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids
[作者：Anavi-Goffer, S; Baillie, G; Irving, AJ; Gertsch, J; Greig, IR; Pertwee, RG; Ross, RA,期刊：Journal of Biological Chemistry, 页码：91-104 , 文章类型： Article，,卷期：2012年287-1]
- GPR55 is activated by L-alpha-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various cannabinoids, including analogues of the CB1 receptor antago...
- alpha-N-Acetylgalactosaminidase from Infant-associated Bifidobacteria Belonging to Novel Glycoside Hydrolase Family 129 Is Implicated in Alternative Mucin Degradation Pathway
[作者：Kiyohara, M; Nakatomi, T; Kurihara, S; Fushinobu, S; Suzuki, H; Tanaka, T; Shoda, S; Kitaoka, M; Katayama, T; Yamamoto, K; Ashida, H,期刊：Journal of Biological Chemistry, 页码：693-700 , 文章类型： Article，,卷期：2012年287-1]
- Bifidobacteria inhabit the lower intestine of mammals including humans where the mucin gel layer forms a space for commensal bacteria. We previously identified that infant-associated bifidobacteria possess an extracellul...
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