- Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles
[作者:Bilyy, RO; Shkandina, T; Tomin, A; Munoz, LE; Franz, S; Antonyuk, V; Kit, YY; Zirngibl, M; Furnrohr, BG; Janko, C; Lauber, K; Schiller, M; Schett, G; Stoika, RS; Herrmann, M,期刊:Journal of Biological Chemistry, 页码:496-503 , 文章类型: Article,,卷期:2012年287-1]
- Inappropriate clearance of apoptotic remnants is considered to be the primary cause of systemic autoimmune diseases, like systemic lupus erythematosus. Here we demonstrate that apoptotic cells release distinct types of s...
- Molecular Determinants of Modulation of Ca(V)2.1 Channels by Visinin-like Protein 2
[作者:Nanou, E; Martinez, GQ; Scheuer, T; Catterall, WA,期刊:Journal of Biological Chemistry, 页码:504-513 , 文章类型: Article,,卷期:2012年287-1]
- CaV2.1 channels, which conduct P/Q-type Ca2+ currents, initiate synaptic transmission at most synapses in the central nervous system. Ca2+/calmodulin-dependent facilitation and inactivation of these channels contributes ...
- Neutral Sphingomyelinase 2 Activity and Protein Stability Are Modulated by Phosphorylation of Five Conserved Serines
[作者:Filosto, S; Ashfaq, M; Chung, S; Fry, W; Goldkorn, T,期刊:Journal of Biological Chemistry, 页码:514-522 , 文章类型: Article,,卷期:2012年287-1]
- We previously presented that the neutral sphingomyelinase 2 (nSMase2) is the only SMase activated in human airway epithelial (HAE) cells following exposure to oxidative stress (ox-stress), yielding ceramide accumulation ...
- Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme
[作者:Durcan, TM; Kontogiannea, M; Bedard, N; Wing, SS; Fon, EA,期刊:Journal of Biological Chemistry, 页码:531-541 , 文章类型: Article,,卷期:2012年287-1]
- We reported previously that parkin, a Parkinson disease-associated E3 ubiquitin-ligase interacts with ataxin-3, a deubiquitinating enzyme associated with Machado-Joseph disease. Ataxin-3 was found to counteract parkin se...
- Increasing Rate of Cleavage at Boundary between Non-structural Proteins 4B and 5A Inhibits Replication of Hepatitis C Virus
[作者:Herod, MR; Jones, DM; McLauchlan, J; McCormick, CJ,期刊:Journal of Biological Chemistry, 页码:568-580 , 文章类型: Article,,卷期:2012年287-1]
- In hepatitis C virus, non-structural proteins are cleaved from the viral polyprotein by viral encoded proteases. Although proteolytic processing goes to completion, the rate of cleavage differs between different boundari...
- Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
[作者:Glidden, EJ; Gray, LG; Vemuru, S; Li, D; Harris, TE; Mayo, MW,期刊:Journal of Biological Chemistry, 页码:581-588 , 文章类型: Article,,卷期:2012年287-1]
- The serine/threonine protein kinase Akt is a critical regulator of cell growth and survival in response to growth factors. A key step in Akt activation is phosphorylation at Ser-473 by the mammalian target of rapamycin (...
- Cardiac Hypertrophy Is Positively Regulated by MicroRNA miR-23a
[作者:Wang, K; Lin, ZQ; Long, B; Li, JH; Zhou, J; Li, PF,期刊:Journal of Biological Chemistry, 页码:589-599 , 文章类型: Article,,卷期:2012年287-1]
- MicroRNAs (miRNAs) are a class of small noncoding RNAs that mediate post-transcriptional gene silencing. Myocardial hypertrophy is frequently associated with the development of heart failure. A variety of miRNAs are invo...
- Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes
[作者:Lok, HC; Rahmanto, YS; Hawkins, CL; Kalinowski, DS; Morrow, CS; Townsend, AJ; Ponka, P; Richardson, DR,期刊:Journal of Biological Chemistry, 页码:607-618 , 文章类型: Article,,卷期:2012年287-1]
- Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron release. We showed that NO-mediated iron efflux from cells required glutathione (GSH) (Watts, ...
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