- Direct Interaction between Scaffolding Proteins RACK1 and 14-3-3 zeta Regulates Brain-derived Neurotrophic Factor ( BDNF) Transcription
[作者：Neasta, J; Kiely, PA; He, DY; Adams, DR; O'Connor, R; Ron, D,期刊：Journal of Biological Chemistry, 页码：322-336 , 文章类型： Article，,卷期：2012年287-1]
- RACK1 is a scaffolding protein that spatially and temporally regulates numerous signaling cascades. We previously found that activation of the cAMP signaling pathway induces the translocation of RACK1 to the nucleus. We ...
- Low Resolution Structure and Dynamics of a Colicin-Receptor Complex Determined by Neutron Scattering
[作者：Clifton, LA; Johnson, CL; Solovyova, AS; Callow, P; Weiss, KL; Ridley, H; Le Brun, AP; Kinane, CJ; Webster, JRP; Holt, SA; Lakey, JH,期刊：Journal of Biological Chemistry, 页码：337-346 , 文章类型： Article，,卷期：2012年287-1]
- Proteins that translocate across cell membranes need to overcome a significant hydrophobic barrier. This is usually accomplished via specialized protein complexes, which provide a polar transmembrane pore. Exceptions to ...
- Fructose Uptake in Bifidobacterium longum NCC2705 Is Mediated by an ATP-binding Cassette Transporter
[作者：Wei, X; Guo, YH; Shao, CL; Sun, ZK; Zhurina, D; Liu, DW; Liu, W; Zou, DY; Jiang, Z; Wang, XS; Zhao, JL; Shang, W; Li, XL; Liao, XR; Huang, LY; Riedel, CU; Yuan, J,期刊：Journal of Biological Chemistry, 页码：357-367 , 文章类型： Article，,卷期：2012年287-1]
- Recently, a putative ATP-binding cassette (ABC) transport system was identified in Bifidobacterium longum NCC2705 that is highly up-regulated during growth on fructose as the sole carbon source. Cloning and expression of...
- Quality Control of Fungus-specific Glucosylceramide in Cryptococcus neoformans by Endoglycoceramidase-related Protein 1 (EGCrP1)
[作者：Ishibashi, Y; Ikeda, K; Sakaguchi, K; Okino, N; Taguchi, R; Ito, M,期刊：Journal of Biological Chemistry, 页码：368-381 , 文章类型： Article，,卷期：2012年287-1]
- A fungus-specific glucosylceramide (GlcCer), which contains a unique sphingoid base possessing two double bonds and a methyl substitution, is essential for pathogenicity in fungi. Although the biosynthetic pathway of the...
- CUEDC2 (CUE Domain-containing 2) and SOCS3 (Suppressors of Cytokine Signaling 3) Cooperate to Negatively Regulate Janus Kinase 1/Signal Transducers and Activators of Transcription 3 Signaling
[作者：Zhang, WN; Wang, L; Wang, Q; Luo, X; Fang, DF; Chen, Y; Pan, X; Man, JH; Xia, Q; Jin, BF; Li, WH; Li, T; Liang, B; Chen, L; Gong, WL; Yu, M; Li, AL; Zhou, T; Li, HY,期刊：Journal of Biological Chemistry, 页码：382-392 , 文章类型： Article，,卷期：2012年287-1]
- Janus kinase 1/signal transducers and activators of transcription 3 (JAK1/STAT3) pathway is one of the recognized oncogenic signaling pathways that frequently overactivated in a variety of human tumors. Despite rapid pro...
- Phospholipase D2 (PLD2) Shortens the Time Required for Myeloid Leukemic Cell Differentiation MECHANISM OF ACTION
[作者：Di Fulvio, M; Frondorf, K; Henkels, KM; Grunwald, WC; Cool, D; Gomez-Cambronero, J,期刊：Journal of Biological Chemistry, 页码：393-407 , 文章类型： Article，,卷期：2012年287-1]
- Cell differentiation is compromised in acute leukemias. We report that mammalian target of rapamycin (mTOR) and S6 kinase (S6K) are highly expressed in the undifferentiated promyelomonocytic leukemic HL-60 cell line, whe...
- Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism
[作者：Maruyama, S; Shibata, R; Kikuchi, R; Izumiya, Y; Rokutanda, T; Araki, S; Kataoka, Y; Ohashi, K; Daida, H; Kihara, S; Ogawa, H; Murohara, T; Ouchi, N,期刊：Journal of Biological Chemistry, 页码：408-417 , 文章类型： Article，,卷期：2012年287-1]
- Obesity-related diseases are associated with vascular dysfunction and impaired revascularization. Omentin is a fat-derived secreted protein, which is down-regulated in association with obese complications. Here, we inves...
- Outer Membrane Lipoprotein Lpp Is Gram-negative Bacterial Cell Surface Receptor for Cationic Antimicrobial Peptides
[作者：Chang, TW; Lin, YM; Wang, CF; Liao, YD,期刊：Journal of Biological Chemistry, 页码：418-428 , 文章类型： Article，,卷期：2012年287-1]
- Antimicrobial peptides/proteins (AMPs) are important components of the host innate defense mechanisms. Here we demonstrate that the outer membrane lipoprotein, Lpp, of Enterobacteriaceae interacts with and promotes susce...
- Loss of the Methyl Lysine Effector Protein PHF20 Impacts the Expression of Genes Regulated by the Lysine Acetyltransferase MOF
[作者：Badeaux, AI; Yang, YZ; Cardenas, K; Vemulapalli, V; Chen, KF; Kusewitt, D; Richie, E; Li, W; Bedford, MT,期刊：Journal of Biological Chemistry, 页码：429-437 , 文章类型： Article，,卷期：2012年287-1]
- In epigenetic signaling pathways, histone tails are heavily modified, resulting in the recruitment of effector molecules that can influence transcription. One such molecule, plant homeodomain finger protein 20 (PHF20), u...
- Unifying Concept of Serotonin Transporter-associated Currents
[作者：Schicker, K; Uzelac, Z; Gesmonde, J; Bulling, S; Stockner, T; Freissmuth, M; Boehm, S; Rudnick, G; Sitte, HH; Sandtner, W,期刊：Journal of Biological Chemistry, 页码：438-445 , 文章类型： Article，,卷期：2012年287-1]
- Serotonin (5-HT) uptake by the human serotonin transporter (hSERT) is driven by ion gradients. The stoichiometry of transported 5-HT and ions is predicted to result in electroneutral charge movement. However, hSERT media...
- Structure-guided Engineering of Human Thymidine Kinase 2 as a Positron Emission Tomography Reporter Gene for Enhanced Phosphorylation of Non-natural Thymidine Analog Reporter Probe
[作者：Campbell, DO; Yaghoubi, SS; Su, Y; Lee, JT; Auerbach, MS; Herschman, H; Satyamurthy, N; Czernin, J; Lavie, A; Radu, CG,期刊：Journal of Biological Chemistry, 页码：446-454 , 文章类型： Article，,卷期：2012年287-1]
- Positron emission tomography (PET) reporter gene imaging can be used to non-invasively monitor cell-based therapies. Therapeutic cells engineered to express a PET reporter gene (PRG) specifically accumulate a PET reporte...
- Multiple SecA Molecules Drive Protein Translocation across a Single Translocon with SecG Inversion
[作者：Morita, K; Tokuda, H; Nishiyama, K,期刊：Journal of Biological Chemistry, 页码：455-464 , 文章类型： Article，,卷期：2012年287-1]
- SecA is a translocation ATPase that drives protein translocation. D209N SecA, a dominant-negative mutant, binds ATP but is unable to hydrolyze it. This mutant was inactive to proOmpA translocation. However, it generated ...
- MicroRNA 34c Gene Down-regulation via DNA Methylation Promotes Self-renewal and Epithelial-Mesenchymal Transition in Breast Tumor-initiating Cells
[作者：Yu, FY; Jiao, Y; Zhu, YH; Wang, Y; Zhu, JD; Cui, XY; Liu, YJ; He, YH; Park, EY; Zhang, HY; Lv, XB; Ma, KL; Su, FX; Park, JH; Song, EW,期刊：Journal of Biological Chemistry, 页码：465-473 , 文章类型： Article，,卷期：2012年287-1]
- Tumor-initiating cells (T-ICs), a subpopulation of cancer cells with stem cell-like properties, are related to tumor relapse and metastasis. Our previous studies identified a distinct profile of microRNA (miRNA) expressi...
- Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)
[作者：Fick, A; Lang, I; Schafer, V; Seher, A; Trebing, J; Weisenberger, D; Wajant, H,期刊：Journal of Biological Chemistry, 页码：484-495 , 文章类型： Article，,卷期：2012年287-1]
- To perform highly sensitive cellular binding studies with TNF-like weak inducer of apoptosis (TWEAK), we developed a bioluminescent variant of soluble TWEAK (GpL-FLAG-TNC-TWEAK) by fusing it genetically to the C terminus...
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