- Structure of Myostatin.Follistatin-like 3 N-TERMINAL DOMAINS OF FOLLISTATIN-TYPE MOLECULES EXHIBIT ALTERNATE MODES OF BINDING
[作者:Cash, JN; Angerman, EB; Kattamuri, C; Nolan, K; Zhao, HY; Sidis, Y; Keutmann, HT; Thompson, TB,期刊:Journal of Biological Chemistry, 页码:1043-1053 , 文章类型: Article,,卷期:2012年287-2]
- TGF-beta family ligands are involved in a variety of critical physiological processes. For instance, the TGF-beta ligand myostatin is a staunch negative regulator of muscle growth and a therapeutic target for muscle-wast...
- Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule
[作者:Zhao, LX; He, F; Liu, HY; Zhu, YS; Tian, WL; Gao, P; He, HP; Yue, W; Lei, XB; Ni, BY; Wang, XH; Jin, HJ; Hao, XJ; Lin, JL; Chen, Q,期刊:Journal of Biological Chemistry, 页码:1054-1065 , 文章类型: Article,,卷期:2012年287-2]
- Overwhelming evidence indicates that Bax and Bak are indispensable for mediating cytochrome c release from mitochondria during apoptosis. Here we report a Bax/Bak-independent mechanism of cytochrome c release and apoptos...
- Formation of Ternary Complex of Human Biliverdin Reductase-Protein Kinase C delta-ERK2 Protein Is Essential for ERK2-mediated Activation of Elk1 Protein, Nuclear Factor-kappa B, and Inducible Nitric-oxidase Synthase (iNOS)
[作者:Gibbs, PEM; Miralem, T; Lerner-Marmarosh, N; Tudor, C; Maines, MD,期刊:Journal of Biological Chemistry, 页码:1066-1079 , 文章类型: Article,,卷期:2012年287-2]
- Growth factors, insulin, oxidative stress, and cytokines activate ERK1/2 by PKC delta and MEK1/2. Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase and intracellular scaffold/bridge/anchor, is a nuclear transporter...
- Connexin 39.9 Protein Is Necessary for Coordinated Activation of Slow-twitch Muscle and Normal Behavior in Zebrafish
[作者:Hirata, H; Wen, H; Kawakami, Y; Naganawa, Y; Ogino, K; Yamada, K; Saint-Amant, L; Low, SE; Cui, WW; Zhou, WB; Sprague, SM; Asakawa, K; Muto, A; Kawakami, K; Kuwada, JY,期刊:Journal of Biological Chemistry, 页码:1080-1089 , 文章类型: Article,,卷期:2012年287-2]
- In many tissues and organs, connexin proteins assemble between neighboring cells to form gap junctions. These gap junctions facilitate direct intercellular communication between adjoining cells, allowing for the transmis...
- Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes
[作者:Schroder, S; Cho, SY; Zeng, L; Zhang, Q; Kaehlcke, K; Mak, L; Lau, J; Bisgrove, D; Schnolzer, M; Verdin, E; Zhou, MM; Ott, M,期刊:Journal of Biological Chemistry, 页码:1090-1099 , 文章类型: Article,,卷期:2012年287-2]
- The positive transcription elongation factor b (P-TEFb) exists in two forms in cells as follows: an inactive form where the core components cyclin T1 and CDK9 are incorporated in the 7SK small nuclear ribonucleoprotein c...
- Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-beta Production by Altering Nicastrin Maturation and Intracellular Localization
[作者:Michaki, V; Guix, FX; Vennekens, K; Munck, S; Dingwall, C; Davis, JB; Townsend, DM; Tew, KD; Feiguin, F; De Strooper, B; Dotti, CG; Wahle, T,期刊:Journal of Biological Chemistry, 页码:1100-1111 , 文章类型: Article,,卷期:2012年287-2]
- Clinical, pharmacological, biochemical, and genetic evidence support the notion that alteration of cholesterol homeostasis strongly predisposes to Alzheimer disease (AD). The ATP-binding cassette transporter-2 (Abca2), w...
- Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy
[作者:Verhalen, B; Ernst, S; Borsch, M; Wilkens, S,期刊:Journal of Biological Chemistry, 页码:1112-1127 , 文章类型: Article,,卷期:2012年287-2]
- P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, functions as an ATP hydrolysis-driven efflux pump torid the cell of toxic organic compounds, including a variety of drugs used in anticancer ...
- Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein alpha B-crystallin
[作者:Mainz, A; Bardiaux, B; Kuppler, F; Multhaup, G; Felli, IC; Pierattelli, R; Reif, B,期刊:Journal of Biological Chemistry, 页码:1128-1138 , 文章类型: Article,,卷期:2012年287-2]
- The human small heat-shock protein alpha B-crystallin (alpha B) rescues misfolded proteins from irreversible aggregation during cellular stress. Binding of Cu(II) was shown to modulate the oligomeric architecture and the...
- Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a '
[作者:Wang, C; Yu, J; Huo, L; Wang, L; Feng, W; Wang, CC,期刊:Journal of Biological Chemistry, 页码:1139-1149 , 文章类型: Article,,卷期:2012年287-2]
- Protein-disulfide isomerase (PDI), with domains arranged as abb'xa'c, is a key enzyme and chaperone localized in the endoplasmic reticulum (ER) catalyzing oxidative folding and preventing misfolding/aggregation of protei...
- Negative Cross-talk between Calcium-sensing Receptor and beta-Catenin Signaling Systems in Colonic Epithelium
[作者:Rey, O; Chang, WH; Bikle, D; Rozengurt, N; Young, SH; Rozengurt, E,期刊:Journal of Biological Chemistry, 页码:1158-1167 , 文章类型: Article,,卷期:2012年287-2]
- Here, we examined the role of the extracellular Ca(2+)-sensing receptor (CaSR) in the control of colonic epithelial cell proliferation in vivo and changes in beta-catenin triggered by CaSR stimulation in human colonic ep...
|