- LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake
[作者:Ye, ZJ; Go, GW; Singh, R; Liu, WZ; Keramati, AR; Mani, A,期刊:Journal of Biological Chemistry, 页码:1335-1344 , 文章类型: Article,,卷期:2012年287-2]
- Genetic variations in LRP6 gene are associated with high serum LDL cholesterol levels. We have previously shown that LDL clearance in peripheral B-lymphocytes of the LRP6(R611C) mutation carriers is significantly impaire...
- Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models
[作者:Mochel, F; Durant, B; Meng, XL; O'Callaghan, J; Yu, H; Brouillet, E; Wheeler, VC; Humbert, S; Schiffmann, R; Durr, A,期刊:Journal of Biological Chemistry, 页码:1361-1370 , 文章类型: Article,,卷期:2012年287-2]
- Brain energy deficit has been a suggested cause of Huntington disease (HD), but ATP depletion has not reliably been shown in preclinical models, possibly because of the immediate post-mortem changes in cellular energy me...
- Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc
[作者:Latypov, RF; Hogan, S; Lau, H; Gadgil, H; Liu, DJ,期刊:Journal of Biological Chemistry, 页码:1381-1396 , 文章类型: Article,,卷期:2012年287-2]
- Understanding the underlying mechanisms of Fc aggregation is an important prerequisite for developing stable and efficacious antibody-based therapeutics. In our study, high resolution two-dimensional nuclear magnetic res...
- Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs
[作者:Kosaka, N; Iguchi, H; Yoshioka, Y; Hagiwara, K; Takeshita, F; Ochiya, T,期刊:Journal of Biological Chemistry, 页码:1397-1405 , 文章类型: Article,,卷期:2012年287-2]
- Normal epithelial cells regulate the secretion of autocrine and paracrine factors that prevent aberrant growth of neighboring cells, leading to healthy development and normal metabolism. One reason for tumor initiation i...
- A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein
[作者:Baldo, B; Weiss, A; Parker, CN; Bibel, M; Paganetti, P; Kaupmann, K,期刊:Journal of Biological Chemistry, 页码:1406-1414 , 文章类型: Article,,卷期:2012年287-2]
- Mechanisms to reduce the cellular levels of mutant huntingtin (mHtt) provide promising strategies for treating Huntington disease (HD). To identify compounds enhancing the degradation of mHtt, we performed a high through...
- Neutrons, Magnets, and Photons: A Career in Structural Biology
[作者:Moore, PB,期刊:Journal of Biological Chemistry, 页码:805-818 , 文章类型: Article,,卷期:2012年287-2]
- The purpose of Reflections articles, it seems, is to give elderly scientists a chance to write about the "good old days," when everyone walked to school in the snow. They enjoy this activity so much that your editor, Mar...
- Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358
[作者:Sharma, M; Jamieson, C; Johnson, M; Molloy, MP; Henderson, BR,期刊:Journal of Biological Chemistry, 页码:819-831 , 文章类型: Article,,卷期:2012年287-2]
- beta-Catenin transduces the Wnt signal from the membrane to nucleus, and certain gene mutations trigger its nuclear accumulation leading to cell transformation and cancer. beta-Catenin shuttles between the nucleus and cy...
- Streptococcus pyogenes in Human Plasma ADAPTIVE MECHANISMS ANALYZED BY MASS SPECTROMETRY-BASED PROTEOMICS
[作者:Malmstrom, J; Karlsson, C; Nordenfelt, P; Ossola, R; Weisser, H; Quandt, A; Hansson, K; Aebersold, R; Malmstrom, L; Bjorck, L,期刊:Journal of Biological Chemistry, 页码:1415-1425 , 文章类型: Article,,卷期:2012年287-2]
- Streptococcus pyogenes is a major bacterial pathogen and a potent inducer of inflammation causing plasma leakage at the site of infection. A combination of label-free quantitative mass spectrometry-based proteomics strat...
- Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparum AN ANTIPARASITIC DRUG TARGET
[作者:Lee, SG; Kim, Y; Alpert, TD; Nagata, A; Jez, JM,期刊:Journal of Biological Chemistry, 页码:1426-1434 , 文章类型: Article,,卷期:2012年287-2]
- In the malarial parasite Plasmodium falciparum, a multifunctional phosphoethanolamine methyltransferase (PfPMT) catalyzes the methylation of phosphoethanolamine (pEA) to phosphocholine for membrane biogenesis. This pathw...
- Signal-dependent Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate without Activation of Phospholipase C IMPLICATIONS ON GATING OF DROSOPHILA TRPL (TRANSIENT RECEPTOR POTENTIAL-LIKE) CHANNEL
[作者:Lev, S; Katz, B; Tzarfaty, V; Minke, B,期刊:Journal of Biological Chemistry, 页码:1436-1447 , 文章类型: Article,,卷期:2012年287-2]
- In Drosophila, a phospholipase C (PLC)-mediated signaling cascade, couples photo-excitation of rhodopsin to the opening of the transient receptor potential (TRP) and TRP-like (TRPL) channels. A lipid product of PLC, diac...
- Alternative Splicing at C Terminus of Ca(V)1.4 Calcium Channel Modulates Calcium-dependent Inactivation, Activation Potential, and Current Density
[作者:Tan, GMY; Yu, DJ; Wang, JJ; Soong, TW,期刊:Journal of Biological Chemistry, 页码:832-847 , 文章类型: Article,,卷期:2012年287-2]
- The Ca(V)1.4 voltage-gated calcium channel is predominantly expressed in the retina, and mutations to this channel have been associated with human congenital stationary night blindness type-2. The L-type Ca(V)1.4 channel...
- Augmented Phosphorylation of Cardiac Troponin I in Hypertensive Heart Failure
[作者:Dong, XT; Sumandea, CA; Chen, YC; Garcia-Cazarin, ML; Zhang, J; Balke, CW; Sumandea, MP; Ge, Y,期刊:Journal of Biological Chemistry, 页码:848-857 , 文章类型: Article,,卷期:2012年287-2]
- An altered cardiac myofilament response to activating Ca(2+) is a hallmark of human heart failure. Phosphorylation of cardiac troponin I (cTnI) is critical in modulating contractility and Ca(2+) sensitivity of cardiac mu...
- A Myeloid Hypoxia-inducible Factor 1 alpha-Kruppel-like Factor 2 Pathway Regulates Gram-positive Endotoxin-mediated Sepsis
[作者:Mahabeleshwar, GH; Qureshi, MA; Takami, Y; Sharma, N; Lingrel, JB; Jain, MK,期刊:Journal of Biological Chemistry, 页码:1448-1457 , 文章类型: Article,,卷期:2012年287-2]
- Although Gram-positive infections account for the majority of cases of sepsis, the molecular mechanisms underlying their effects remains poorly understood. We investigated how cell wall components of Gram-positive bacter...
|