- Loss of Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein alpha (alpha SNAP) Induces Epithelial Cell Apoptosis via Down-regulation of Bcl-2 Expression and Disruption of the Golgi
[作者:Naydenov, NG; Harris, G; Brown, B; Schaefer, KL; Das, SK; Fisher, PB; Ivanov, AI,期刊:Journal of Biological Chemistry, 页码:5928-5941 , 文章类型: Article,,卷期:2012年287-8]
- Intracellular trafficking represents a key mechanism that regulates cell fate by participating in either prodeath or prosurvival signaling. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (alpha ...
- Different Requirements for Proteolytic Processing of Bone Morphogenetic Protein 5/6/7/8 Ligands in Drosophila melanogaster
[作者:Fritsch, C; Sawala, A; Harris, R; Maartens, A; Sutcliffe, C; Ashe, HL; Ray, RP,期刊:Journal of Biological Chemistry, 页码:5942-5953 , 文章类型: Article,,卷期:2012年287-8]
- Bone morphogenetic proteins (BMPs) are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein convertases to release the active ligand. Here we study processing of BMP5/6/7/8 protei...
- Modified Low Density Lipoprotein Stimulates Complement C3 Expression and Secretion via Liver X Receptor and Toll-like Receptor 4 Activation in Human Macrophages
[作者:Mogilenko, DA; Kudriavtsev, IV; Trulioff, AS; Shavva, VS; Dizhe, EB; Missyul, BV; Zhakhov, AV; Ischenko, AM; Perevozchikov, AP; Orlov, SV,期刊:Journal of Biological Chemistry, 页码:5954-5968 , 文章类型: Article,,卷期:2012年287-8]
- Complement C3 is a pivotal component of three cascades of complement activation. C3 is expressed in human atherosclerotic lesions and is involved in atherogenesis. However, the mechanism of C3 accumulation in atheroscler...
- SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells
[作者:Shimozaki, K; Zhang, CL; Suh, H; Denli, AM; Evans, RM; Gage, FH,期刊:Journal of Biological Chemistry, 页码:5969-5978 , 文章类型: Article,,卷期:2012年287-8]
- Adult neurogenesis is maintained by self-renewable neural stem cells (NSCs). Their activity is regulated by multiple signaling pathways and key transcription factors. However, it has been unclear whether these factors in...
- Trinucleotide Repeat Containing 6a (Tnrc6a)-mediated MicroRNA Function Is Required for Development of Yolk Sac Endoderm
[作者:Jiang, ZH; Yu, N; Kuang, PP; Chen, M; Shao, FZ; Martin, G; Chui, DHK; Cardoso, WV; Ai, XB; Lu, JN,期刊:Journal of Biological Chemistry, 页码:5979-5987 , 文章类型: Article,,卷期:2012年287-8]
- Tnrc6 family members (Tnrc6a/b/c) are key components of the RNA-induced silencing complex in microRNA (miRNA)mediated gene suppression. Here, we show that Tnrc6a, also known as GW182, is selectively expressed in the yolk...
- Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases
[作者:Lee, S; Thebault, P; Freschi, L; Beaufils, S; Blundell, TL; Landry, CR; Bolanos-Garcia, VM; Elowe, S,期刊:Journal of Biological Chemistry, 页码:5988-6001 , 文章类型: Article,,卷期:2012年287-8]
- Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ens...
- Up-regulation of Cav beta(3) Subunit in Primary Sensory Neurons Increases Voltage-activated Ca2+ Channel Activity and Nociceptive Input in Neuropathic Pain
[作者:Li, L; Cao, XH; Chen, SR; Han, HD; Lopez-Berestein, G; Sood, AK; Pan, HL,期刊:Journal of Biological Chemistry, 页码:6002-6013 , 文章类型: Article,,卷期:2012年287-8]
- High voltage-activated calcium channels (HVACCs) are essential for synaptic and nociceptive transmission. Although blocking HVACCs can effectively reduce pain, this treatment strategy is associated with intolerable adver...
- Axonal Neuropathy-associated TRPV4 Regulates Neurotrophic Factor-derived Axonal Growth
[作者:Jang, Y; Jung, J; Kim, H; Oh, J; Jeon, JH; Jung, S; Kim, KT; Cho, H; Yang, DJ; Kim, SM; Kim, IB; Song, MR; Oh, U,期刊:Journal of Biological Chemistry, 页码:6014-6024 , 文章类型: Article,,卷期:2012年287-8]
- Spinal muscular atrophy and hereditary motor and sensory neuropathies are characterized by muscle weakness and atrophy caused by the degenerations of peripheral motor and sensory nerves. Recent advances in genetics have ...
- Functional RNA Interference (RNAi) Screen Identifies System A Neutral Amino Acid Transporter 2 (SNAT2) as a Mediator of Arsenic-induced Endoplasmic Reticulum Stress
[作者:Oh, RS; Pan, WC; Yalcin, A; Zhang, H; Guilarte, TR; Hotamisligil, GS; Christiani, DC; Lu, Q,期刊:Journal of Biological Chemistry, 页码:6025-6034 , 文章类型: Article,,卷期:2012年287-8]
- Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress at the cellular level. Adaptive responses to ER stress are implicated in canc...
- gamma delta T Cell Receptors Recognize the Non-classical Major Histocompatibility Complex (MHC) Molecule T22 via Conserved Anchor Residues in a MHC Peptide-like Fashion
[作者:Sandstrom, A; Scharf, L; McRae, G; Hawk, AJ; Meredith, SC; Adams, EJ,期刊:Journal of Biological Chemistry, 页码:6035-6043 , 文章类型: Article,,卷期:2012年287-8]
- The molecular mechanisms by which gamma delta T cells recognize ligand remain a mystery. The non-classical MHC molecule T22 represents the best characterized ligand for murine gamma delta T cells, with a motif (W ... EGY...
- The C-terminal Helices of Heat Shock Protein 70 Are Essential for J-domain Binding and ATPase Activation
[作者:Gao, XC; Zhou, CJ; Zhou, ZR; Wu, M; Cao, CY; Hu, HY,期刊:Journal of Biological Chemistry, 页码:6044-6052 , 文章类型: Article,,卷期:2012年287-8]
- The J-domain co-chaperones work together with the heat shock protein 70 (HSP70) chaperone to regulate many cellular events, but the mechanism underlying the J-domain-mediated HSP70 function remains elusive. We studied th...
- Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNF alpha-induced Jun NH2-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein
[作者:Scudiero, I; Zotti, T; Ferravante, A; Vessichelli, M; Reale, C; Masone, MC; Leonardi, A; Vito, P; Stilo, R,期刊:Journal of Biological Chemistry, 页码:6053-6061 , 文章类型: Article,,卷期:2012年287-8]
- The pro-inflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNF alpha treatment is determined by the balance between survival factors and Jun NH2-termin...
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