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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共79条记录   Structural Basis for Increased Toxicity of Pathological A beta(42):A beta(40) Ratios in Alzheimer Disease [作者：Pauwels, K; Williams, TL; Morris, KL; Jonckheere, W; Vandersteen, A; Kelly, G; Schymkowitz, J; Rousseau, F; Pastore, A; Serpell, LC; Broersen, K,期刊：Journal of Biological Chemistry, 页码：5650-5660 , 文章类型： Article，,卷期：2012年287-8] The beta-amyloid peptide (A beta) is directly related to neurotoxicity in Alzheimer disease (AD). The two most abundant alloforms of the peptide co-exist under normal physiological conditions in the brain in an A beta(42... Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity [作者：Xu, XP; Sarbeng, EB; Vorvis, C; Kumar, DP; Zhou, L; Liu, QL,期刊：Journal of Biological Chemistry, 页码：5661-5672 , 文章类型： Article，,卷期：2012年287-8] The molecular chaperone 70-kDa heat-shock proteins (Hsp70s) play essential roles in maintaining protein homeostasis. Hsp110, an Hsp70 homolog, is highly efficient in preventing protein aggregation but lacks the hallmark ... Membrane Binding Events in the Initiation and Propagation Phases of Tissue Factor-initiated Zymogen Activation under Flow [作者：Haynes, LM; Dubief, YC; Mann, KG,期刊：Journal of Biological Chemistry, 页码：5225-5234 , 文章类型： Article，,卷期：2012年287-8] This study investigates the dynamics of zymogen activation when both extrinsic tenase and prothrombinase are assembled on an appropriate membrane. Although the activation of prothrombin by surface-localized prothrombinas... Fibril Structure of Human Islet Amyloid Polypeptide [作者：Bedrood, S; Li, YY; Isas, JM; Hegde, BG; Baxa, U; Haworth, IS; Langen, R,期刊：Journal of Biological Chemistry, 页码：5235-5241 , 文章类型： Article，,卷期：2012年287-8] Misfolding and amyloid fibril formation by human islet amyloid polypeptide (hIAPP) are thought to be important in the pathogenesis of type 2 diabetes, but the structures of the misfolded forms remain poorly understood. H... Multiple Members of the UDP-GalNAc: Polypeptide N-Acetylgalactosaminyltransferase Family Are Essential for Viability in Drosophila [作者：Tran, DT; Zhang, LP; Zhang, Y; Tian, E; Earl, LA; Ten Hagen, KG,期刊：Journal of Biological Chemistry, 页码：5243-5252 , 文章类型： Article，,卷期：2012年287-8] Mucin-type O-glycosylation represents a major form of post-translational modification that is conserved across most eukaryotic species. This type of glycosylation is initiated by a family of enzymes (GalNAc-Ts in mammals... Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site [作者：Feng, Y; Mckee, K; Tran, K; O'Dell, S; Schmidt, SD; Phogat, A; Forsell, MN; Hedestam, GBK; Mascola, JR; Wyatt, RT,期刊：Journal of Biological Chemistry, 页码：5673-5686 , 文章类型： Article，,卷期：2012年287-8] HIV-1 gp120 binds the primary receptor CD4. Recently, a plethora of broadly neutralizing antibodies to the gp120 CD4-binding site (CD4bs) validated this region as a target for immunogen design. Here, we asked if modified... Novel cis-Regulatory Modules Control Expression of the Hairy and Enhancer of Split-1 (HES1) Transcription Factor in Myoblasts [作者：Jeziorska, DM; Koentges, G; Vance, KW,期刊：Journal of Biological Chemistry, 页码：5687-5697 , 文章类型： Article，,卷期：2012年287-8] The expression profile of a gene is controlled by DNA sequences called cis-regulatory modules (CRMs). CRMs can function over large genomic distances and can be located many kilobases away from their target promoters. hes... Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90 [作者：Jimenez, B; Ugwu, F; Zhao, RM; Orti, L; Makhnevych, T; Pineda-Lucena, A; Houry, WA,期刊：Journal of Biological Chemistry, 页码：5698-5709 , 文章类型： Article，,卷期：2012年287-8] Tah1 and Pih1 are novel Hsp90 interactors. Tah1 acts as a cofactor of Hsp90 to stabilize Pih1. In yeast, Hsp90, Tah1, and Pih1 were found to form a complex that is required for ribosomal RNA processing through their effe... Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons [作者：Chen, HK; Liu, ZP; Meyer-Franke, A; Brodbeck, J; Miranda, RD; McGuire, JG; Pleiss, MA; Ji, ZS; Balestra, ME; Walker, DW; Xu, Q; Jeong, DE; Budamagunta, MS; Voss, JC; Freedman, SB; Weisgraber, KH; Huang, YD; Mahley, RW,期刊：Journal of Biological Chemistry, 页码：5253-5266 , 文章类型： Article，,卷期：2012年287-8] Apolipoprotein E4 (apoE4), the major genetic risk factor for late onset Alzheimer disease, assumes a pathological conformation, intramolecular domain interaction. ApoE4 domain interaction mediates the detrimental effects... Homo sapiens Systemic RNA Interference-defective-1 Transmembrane Family Member 1 (SIDT1) Protein Mediates Contact-dependent Small RNA Transfer and MicroRNA-21-driven Chemoresistance [作者：Elhassan, MO; Christie, J; Duxbury, MS,期刊：Journal of Biological Chemistry, 页码：5267-5277 , 文章类型： Article，,卷期：2012年287-8] Locally initiated RNA interference (RNAi) has the potential for spatial propagation, inducing posttranscriptional gene silencing in distant cells. In Caenorhabditis elegans, systemic RNAi requires a phylogenetically cons... Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase [作者：Kim, W; Chakraborty, G; Kim, S; Shin, J; Park, CH; Jeong, MW; Bharatham, N; Yoon, HS; Kim, KT,期刊：Journal of Biological Chemistry, 页码：5278-5289 , 文章类型： Article，,卷期：2012年287-8] VRK1-mediated phosphorylation of histone H3 should be restricted in mitosis for consistent cell cycling, and defects in this process trigger cellular catastrophe. However, an interphasic regulator against VRK1 has not be... Axonal Gradient of Arachidonic Acid-containing Phosphatidylcholine and Its Dependence on Actin Dynamics [作者：Yang, HJ; Sugiura, Y; Ikegami, K; Konishi, Y; Setou, M,期刊：Journal of Biological Chemistry, 页码：5290-5300 , 文章类型： Article，,卷期：2012年287-8] Phosphatidylcholine (PC) is the most abundant component of lipid bilayers and exists in various molecular forms, through combinations of two acylated fatty acids. Arachidonic acid (AA)-containing PC (AA-PC) can be a sour... Role of Novel Rat-specific Fc Receptor in Macrophage Activation Associated with Crescentic Glomerulonephritis [作者：Page, TH; D'Souza, Z; Nakanishi, S; Serikawa, T; Pusey, CD; Aitman, TJ; Cook, HT; Behmoaras, J,期刊：Journal of Biological Chemistry, 页码：5710-5719 , 文章类型： Article，,卷期：2012年287-8] Crescentic glomerulonephritis (Crgn) is a complex disease where the initial insult is often the glomerular deposition of antibodies against intrinsic or deposited antigens in the glomerulus. The role of Fc receptors in t... Isolation and Characterization of Homodimeric Type-I Reaction Center Complex from Candidatus Chloracidobacterium thermophilum, an Aerobic Chlorophototroph [作者：Tsukatani, Y; Romberger, SP; Golbeck, JH; Bryant, DA,期刊：Journal of Biological Chemistry, 页码：5720-5732 , 文章类型： Article，,卷期：2012年287-8] The recently discovered thermophilic acidobacterium Candidatus Chloracidobacterium thermophilum is the first aerobic chlorophototroph that has a type-I, homodimeric reaction center (RC). This organism and its type-I RCs ... Interleukin 32 (IL-32) Contains a Typical alpha-Helix Bundle Structure That Resembles Focal Adhesion Targeting Region of Focal Adhesion Kinase-1 [作者：Heinhuis, B; Koenders, MI; van den Berg, WB; Netea, MG; Dinarello, CA; Joosten, LAB,期刊：Journal of Biological Chemistry, 页码：5733-5743 , 文章类型： Article，,卷期：2012年287-8] IL-32 can be expressed in several isoforms. The amino acid sequences of the major IL-32 isoforms were used to predict the secondary and tertiary protein structure by I-TASSER software. The secondary protein structure rev... AMP Is an Adenosine A(1) Receptor Agonist [作者：Rittiner, JE; Korboukh, I; Hull-Ryde, EA; Jin, J; Janzen, WP; Frye, SV; Zylka, MJ,期刊：Journal of Biological Chemistry, 页码：5301-5309 , 文章类型： Article，,卷期：2012年287-8] Numerous receptors for ATP, ADP, and adenosine exist; however, it is currently unknown whether a receptor for the related nucleotide adenosine 5'-monophosphate (AMP) exists. Using a novel cell-based assay to visualize ad...