- Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide
[作者:Yao, X; Chong, HH; Zhang, C; Waltersperger, S; Wang, MT; Cui, S; He, YX,期刊:Journal of Biological Chemistry, 页码:6788-6796 , 文章类型: Article,,卷期:2012年287-9]
- Sifuvirtide (SFT) is an electrostatically constrained alpha-helical peptide fusion inhibitor showing potent anti-HIV activity, good safety, and pharmacokinetic profiles, and it is currently under phase II clinical trials...
- Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET)
[作者:Davydov, DR; Rumfeldt, JAO; Sineva, EV; Fernando, H; Davydova, NY; Halpert, JR,期刊:Journal of Biological Chemistry, 页码:6797-6809 , 文章类型: Article,,卷期:2012年287-9]
- The mechanisms of ligand binding and allostery in the major human drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) were explored with fluorescence resonance energy transfer (FRET) using a laser dye, fluorol-7GA (F7G...
- Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor kappa B Activation
[作者:Zhang, QH; Wang, CM; Liu, ZL; Liu, XG; Han, CF; Cao, XT; Li, N,期刊:Journal of Biological Chemistry, 页码:6208-6217 , 文章类型: Article,,卷期:2012年287-9]
- Multiple signaling pathways are involved in the tight regulation of Toll-like receptor (TLR) signaling, which is important for the tailoring of inflammatory response to pathogens in macrophages. It is widely accepted tha...
- Nuclear Factor-kappa B (NF-kappa B) Inhibitory Protein I kappa B beta Determines Apoptotic Cell Death following Exposure to Oxidative Stress
[作者:Wright, CJ; Agboke, F; Muthu, M; Michaelis, KA; Mundy, MA; La, P; Yang, G; Dennery, PA,期刊:Journal of Biological Chemistry, 页码:6230-6239 , 文章类型: Article,,卷期:2012年287-9]
- The transcription factor NF-kappa B regulates the cellular response to inflammatory and oxidant stress. Although many studies have evaluated NF-kappa B activity following exposure to oxidative stress, the role of the I k...
- Direct in Vitro and in Vivo Evidence for Interaction between Hsp47 Protein and Collagen Triple Helix
[作者:Ono, T; Miyazaki, T; Ishida, Y; Uehata, M; Nagata, K,期刊:Journal of Biological Chemistry, 页码:6810-6818 , 文章类型: Article,,卷期:2012年287-9]
- Hsp47 ((h) under bar eat (s) under bar hock (p) under bar rotein (47) under bar), a collagen-specific molecular chaperone, is essential for the maturation of various types of procollagens. Previous studies have suggested...
- Receptor Tyrosine Kinase Ephb6 Regulates Vascular Smooth Muscle Contractility and Modulates Blood Pressure in Concert with Sex Hormones
[作者:Luo, HY; Wu, ZH; Tremblay, J; Thorin, E; Peng, JZ; Lavoie, JL; Hu, B; Stoyanova, E; Cloutier, G; Qi, SJ; Wu, T; Cameron, M; Wu, JP,期刊:Journal of Biological Chemistry, 页码:6819-6829 , 文章类型: Article,,卷期:2012年287-9]
- Eph kinases constitute the largest receptor tyrosine kinase family, and their ligands, ephrins (Efns), are also cell surface molecules. Our study is the first to assess the role of Ephb6 in blood pressure (BP) regulation...
- Malin Regulates Wnt Signaling Pathway through Degradation of Dishevelled2
[作者:Sharma, J; Mulherkar, S; Mukherjee, D; Jana, NR,期刊:Journal of Biological Chemistry, 页码:6830-6839 , 文章类型: Article,,卷期:2012年287-9]
- Using yeast-two hybrid screening followed by co-immuno-precipitation assay, we have found that the Lafora disease ubiquitin ligase malin interacts with dishevelled2, a key mediator of Wnt signaling pathway. Overexpressio...
- Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis
[作者:Zhou, K; Gao, Y; Hoy, JA; Mann, FM; Honzatko, RB; Peters, RJ,期刊:Journal of Biological Chemistry, 页码:6840-6850 , 文章类型: Article,,卷期:2012年287-9]
- Abietadiene synthase from Abies grandis (AgAS) is a model system for diterpene synthase activity, catalyzing class I (ionization-initiated) and class II (protonation-initiated) cyclization reactions. Reported here is the...
- Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells
[作者:Deng, JN; Liu, SX; Zou, LQ; Xu, C; Geng, B; Xu, GH,期刊:Journal of Biological Chemistry, 页码:6240-6249 , 文章类型: Article,,卷期:2012年287-9]
- In obesity and diabetes, adipocytes show significant endoplasmic reticulum (ER) stress, which triggers a series of responses. This study aimed to investigate the lipolysis response to ER stress in rat adipocytes. Thapsig...
- Cdc6 Protein Activates p27(KIP1)-bound Cdk2 Protein Only after the Bound p27 Protein Undergoes C-terminal Phosphorylation
[作者:Uranbileg, B; Yamamoto, H; Park, JH; Mohanty, AR; Arakawa-Takeuchi, S; Jinno, S; Okayama, H,期刊:Journal of Biological Chemistry, 页码:6275-6283 , 文章类型: Article,,卷期:2012年287-9]
- In mammalian cells Cdk2 activity during the G(1)-S transition is mainly controlled by p27(KIP1). Although the amount and subcellular localization of p27 influence Cdk2 activity, how Cdk2 activity is regulated during this...
- Contactin-associated Protein 1 (Caspr1) Regulates the Traffic and Synaptic Content of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)-type Glutamate Receptors
[作者:Santos, SD; Iuliano, O; Ribeiro, L; Veran, J; Ferreira, JS; Rio, P; Mulle, C; Duarte, CB; Carvalho, AL,期刊:Journal of Biological Chemistry, 页码:6868-6877 , 文章类型: Article,,卷期:2012年287-9]
- Glutamate receptors of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type mediate fast excitatory synaptic transmission in the CNS. Synaptic strength is modulated by AMPA receptor binding partners, ...
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