- Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes
[作者:Tan, SX; Ng, Y; Meoli, CC; Kumar, A; Khoo, PS; Fazakerley, DJ; Junutula, JR; Vali, S; James, DE; Stockli, J,期刊:Journal of Biological Chemistry, 页码:6128-6138 , 文章类型: Article,,卷期:2012年287-9]
- Akt plays a major role in insulin regulation of metabolism in muscle, fat, and liver. Here, we show that in 3T3-L1 adipocytes, Akt operates optimally over a limited dynamic range. This indicates that Akt is a highly sens...
- Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
[作者:Hubbi, ME; Gilkes, DM; Baek, JH; Semenza, GL,期刊:Journal of Biological Chemistry, 页码:6139-6149 , 文章类型: Article,,卷期:2012年287-9]
- Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that promotes angiogenesis, metabolic reprogramming, and other critical aspects of cancer biology. The four-and-a-half LIM domain (FHL) proteins are a family o...
- Composition and Dynamics of the Nucleolinus, a Link between the Nucleolus and Cell Division Apparatus in Surf Clam (Spisula) Oocytes
[作者:Alliegro, MC; Hartson, S; Alliegro, MA,期刊:Journal of Biological Chemistry, 页码:6702-6713 , 文章类型: Article,,卷期:2012年287-9]
- The nucleolinus is a little-known cellular structure, discovered over 150 years ago (Agassiz, L. (1857) Contributions to the Natural History of the United States of America, First Monograph, Part IIL, Little, Brown and C...
- Dimeric alpha-Cobratoxin X-ray Structure LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS
[作者:Osipov, AV; Rucktooa, P; Kasheverov, IE; Filkin, SY; Starkov, VG; Andreeva, TV; Sixma, TK; Bertrand, D; Utkin, YN; Tsetlin, VI,期刊:Journal of Biological Chemistry, 页码:6725-6734 , 文章类型: Article,,卷期:2012年287-9]
- In Naja kaouthia cobra venom, we have earlier discovered a covalent dimeric form of alpha-cobratoxin (alpha CT-alpha CT) with two intermolecular disulfides, but we could not determine their positions. Here, we report the...
- Adaptive Evolution of Class 5 Fimbrial Genes in Enterotoxigenic Escherichia coli and Its Functional Consequences
[作者:Chattopadhyay, S; Tchesnokova, V; McVeigh, A; Kisiela, DI; Dori, K; Navarro, A; Sokurenko, EV; Savarino, SJ,期刊:Journal of Biological Chemistry, 页码:6150-6158 , 文章类型: Article,,卷期:2012年287-9]
- Class 5 fimbriae of enterotoxigenic Escherichia coli (ETEC) comprise eight serologically discrete colonization factors that mediate small intestinal adhesion. Their differentiation has been attributed to the pressure imp...
- Characterization of CYP76M5-8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster
[作者:Wang, Q; Hillwig, ML; Okada, K; Yamazaki, K; Wu, YS; Swaminathan, S; Yamane, H; Peters, RJ,期刊:Journal of Biological Chemistry, 页码:6159-6168 , 文章类型: Article,,卷期:2012年287-9]
- Recent reports have revealed genomic clustering of enzymatic genes for particular biosynthetic pathways in plant specialized/secondary metabolism. Rice (Oryza sativa) carries two such clusters for production of antimicro...
- The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain
[作者:Wu, S; Hong, F; Gewirth, D; Guo, BC; Liu, B; Li, ZH,期刊:Journal of Biological Chemistry, 页码:6735-6742 , 文章类型: Article,,卷期:2012年287-9]
- The structural basis for molecular chaperones to discern mis-folded proteins has long been an enigma. As the endoplasmic reticulum paralogue of the cytosolic HSP90, gp96 (GRP94, HSP90b1) is an essential molecular chapero...
- gamma-Aminobutyric Acid Type A (GABA(A)) Receptor Activation Modulates Tau Phosphorylation
[作者:Nykanen, NP; Kysenius, K; Sakha, P; Tammela, P; Huttunen, HJ,期刊:Journal of Biological Chemistry, 页码:6743-6752 , 文章类型: Article,,卷期:2012年287-9]
- Abnormal phosphorylation and aggregation of the microtubule-associated protein Tau are hallmarks of various neurodegenerative diseases, such as Alzheimer disease. Molecular mechanisms that regulate Tau phosphorylation ar...
- Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA
[作者:Xia, W; Li, HY; Yang, XM; Wong, KB; Sun, HZ,期刊:Journal of Biological Chemistry, 页码:6753-6763 , 文章类型: Article,,卷期:2012年287-9]
- The maturation of [NiFe]-hydrogenase is highly dependent on a battery of chaperone proteins. Among these, HypA and HypB were proposed to exert nickel delivery functions in the metallocenter assembly process, although the...
- Chromodomain Helicase DNA-binding Protein 4 (CHD4) Regulates Homologous Recombination DNA Repair, and Its Deficiency Sensitizes Cells to Poly(ADP-ribose) Polymerase (PARP) Inhibitor Treatment
[作者:Pan, MR; Hsieh, HJ; Dai, H; Hung, WC; Li, KY; Peng, G; Lin, SY,期刊:Journal of Biological Chemistry, 页码:6764-6772 , 文章类型: Article,,卷期:2012年287-9]
- To ensure genome stability, cells have evolved a robust defense mechanism to detect, signal, and repair damaged DNA that is generated by exogenous stressors such as ionizing radiation, endogenous stressors such as free r...
- Role of Integrin-beta 3 Protein in Macrophage Polarization and Regeneration of Injured Muscle
[作者:Zhang, LP; Dong, YJ; Dong, YL; Cheng, JZ; Du, J,期刊:Journal of Biological Chemistry, 页码:6177-6186 , 文章类型: Article,,卷期:2012年287-9]
- Following injury, skeletal muscle achieves repair by a highly coordinated, dynamic process resulting from interplay among numerous inflammatory, growth factors and myogenic regulators. To identify genes involved in muscl...
- Regulation of the ATP-sensitive Potassium Channel Subunit, Kir6.2, by a Ca2+-dependent Protein Kinase C
[作者:Aziz, Q; Thomas, AM; Khambra, T; Tinker, A,期刊:Journal of Biological Chemistry, 页码:6196-6207 , 文章类型: Article,,卷期:2012年287-9]
- The activity of ATP-sensitive potassium (K-ATP) channels is governed by the concentration of intracellular ATP and ADP and is thus responsive to the metabolic status of the cell. Phosphorylation of KATP channels by prote...
- The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-beta-dependent Signaling, and Inhibits TGF-beta-dependent Fibrotic Response in Skeletal Muscles
[作者:Cabello-Verrugio, C; Santander, C; Cofre, C; Acuna, MJ; Melo, F; Brandan, E,期刊:Journal of Biological Chemistry, 页码:6773-6787 , 文章类型: Article,,卷期:2012年287-9]
- Decorin is a small proteoglycan, composed of 12 leucine-rich repeats (LRRs) that modulates the activity of transforming growth factor type beta (TGF-beta) and other growth factors, and thereby influences proliferation an...
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