- Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine gamma-Lyase CROSS-TALK BETWEEN INTEGRATED STRESS RESPONSE AND THIOL METABOLISM
[作者:Dickhout, JG; Carlisle, RE; Jerome, DE; Mohammed-Ali, Z; Jiang, H; Yang, GD; Mani, S; Garg, SK; Banerjee, R; Kaufman, RJ; Maclean, KN; Wang, R; Austin, RC,期刊:Journal of Biological Chemistry, 页码:7603-7614 , 文章类型: Article,,卷期:2012年287-10]
- The integrated stress response mediated by eukaryotic translation initiation factor 2 alpha (eIF2 alpha) phosphorylation maintains cellular homeostasis under endoplasmic reticulum (ER) stress. eIF2 alpha phosphorylation ...
- Apolipoprotein A-II-mediated Conformational Changes of Apolipoprotein A-I in Discoidal High Density Lipoproteins
[作者:Gauthamadasa, K; Vaitinadin, NS; Dressman, JL; Macha, S; Homan, R; Greis, KD; Silva, RAGD,期刊:Journal of Biological Chemistry, 页码:7615-7625 , 文章类型: Article,,卷期:2012年287-10]
- It is well accepted that HDL has the ability to reduce risks for several chronic diseases. To gain insights into the functional properties of HDL, it is critical to understand the HDL structure in detail. To understand i...
- Critical Role of Leucine-Valine Change in Distinct Low pH Requirements for Membrane Fusion between Two Related Retrovirus Envelopes
[作者:Cote, M; Zheng, YM; Li, K; Xiang, SH; Albritton, LM; Liu, SL,期刊:Journal of Biological Chemistry, 页码:7640-7651 , 文章类型: Article,,卷期:2012年287-10]
- Many viruses use a pH-dependent pathway for fusion with host cell membrane, the mechanism of which is still poorly understood. Here we report that a subtle leucine (Leu)-valine (Val) change at position 501 in the envelop...
- Structural Dynamics of C-domain of Cardiac Troponin I Protein in Reconstituted Thin Filament
[作者:Zhou, ZQ; Li, KL; Rieck, D; Ouyang, YX; Chandra, M; Dong, WJ,期刊:Journal of Biological Chemistry, 页码:7661-7674 , 文章类型: Article,,卷期:2012年287-10]
- The regulatory function of cardiac troponin I (cTnI) involves three important contiguous regions within its C-domain: the inhibitory region (IR), the regulatory region (RR), and the mobile domain (MD). Within these regio...
- Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells
[作者:Ueta, T; Inoue, T; Furukawa, T; Tamaki, Y; Nakagawa, Y; Imai, H; Yanagi, Y,期刊:Journal of Biological Chemistry, 页码:7675-7682 , 文章类型: Article,,卷期:2012年287-10]
- Oxidative stress is implicated in the pathologies of photoreceptor cells, and the protective role of antioxidant enzymes for photoreceptor cells have been well understood. However, their essentiality has remained unknown...
- Structural Basis for Sequence-specific DNA Recognition by an Arabidopsis WRKY Transcription Factor
[作者:Yamasaki, K; Kigawa, T; Watanabe, S; Inoue, M; Yamasaki, T; Seki, M; Shinozaki, K; Yokoyama, S,期刊:Journal of Biological Chemistry, 页码:7683-7691 , 文章类型: Article,,卷期:2012年287-10]
- The WRKY family transcription factors regulate plant-specific reactions that are mostly related to biotic and abiotic stresses. They share the WRKY domain, which recognizes a DNA element (TTGAC(C/T)) termed the W-box, in...
- Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome A ROLE FOR THE NUCLEAR EXPORT SIGNAL, CRM1, AND AURORA A KINASE
[作者:Brodie, KM; Henderson, BR,期刊:Journal of Biological Chemistry, 页码:7701-7716 , 文章类型: Article,,卷期:2012年287-10]
- BRCA1 is a DNA damage response protein and functions in the nucleus to stimulate DNA repair and at the centrosome to inhibit centrosome overduplication in response to DNA damage. The loss or mutation of BRCA1 causes cent...
- Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase
[作者:Hall, J; Aulabaugh, A; Rajamohan, F; Liu, SP; Kaila, N; Wan, ZK; Ryan, M; Magyar, R; Qiu, XY,期刊:Journal of Biological Chemistry, 页码:7717-7727 , 文章类型: Article,,卷期:2012年287-10]
- Extracellular stimulation of the B cell receptor or mast cell Fc epsilon RI receptor activates a cascade of protein kinases, ultimately leading to antigenic or inflammation immune responses, respectively. Syk is a solubl...
- alpha-Catenin Uses a Novel Mechanism to Activate Vinculin
[作者:Peng, X; Maiers, JL; Choudhury, D; Craig, SW; Demali, KA,期刊:Journal of Biological Chemistry, 页码:7728-7737 , 文章类型: Article,,卷期:2012年287-10]
- Vinculin, an actin-binding protein, is emerging as an important regulator of adherens junctions. In focal-adhesions, vinculin is activated by simultaneous binding of talin to its head domain and actin filaments to its ta...
- Roles of Hydrophobicity and Charge Distribution of Cationic Antimicrobial Peptides in Peptide-Membrane Interactions
[作者:Yin, LM; Edwards, MA; Li, J; Yip, CM; Deber, CM,期刊:Journal of Biological Chemistry, 页码:7738-7745 , 文章类型: Article,,卷期:2012年287-10]
- Cationic antimicrobial peptides (CAPs) occur as important innate immunity agents in many organisms, including humans, and offer a viable alternative to conventional antibiotics, as they physically disrupt the bacterial m...
- Solution Structure of RING Finger-like Domain of Retinoblastoma-binding Protein-6 (RBBP6) Suggests It Functions as a U-box
[作者:Kappo, MA; Eiso, AB; Hassem, F; Atkinson, RA; Faro, A; Muleya, V; Mulaudzi, T; Poole, JO; McKenzie, JM; Chibi, M; Moolman-Smook, JC; Rees, DJG; Pugh, DJR,期刊:Journal of Biological Chemistry, 页码:7146-7158 , 文章类型: Article,,卷期:2012年287-10]
- Retinoblastoma-binding protein-6 (RBBP6) plays a facilitating role, through its RING finger-like domain, in the ubiquitination of p53 by Hdm2 that is suggestive of E4-like activity. Although the presence of eight conserv...
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