- The Leukemia-associated Fusion Protein Tel-Platelet-derived Growth Factor Receptor beta (Tel-PdgfR beta) Inhibits Transcriptional Repression of PTPN13 Gene by Interferon Consensus Sequence Binding Protein (Icsbp)
[作者:Huang, WQ; Hu, LP; Bei, L; Hjort, E; Eklund, EA,期刊:Journal of Biological Chemistry, 页码:8110-8125 , 文章类型: Article,,卷期:2012年287-11]
- Icsbp is an interferon regulatory transcription factor with leukemia suppressor activity. In previous studies, we identified the gene encoding Fas-associated phosphatase 1 (Fap1; the PTPN13 gene) as an Icsbp target. In t...
- The Role of Ras Guanine Nucleotide Releasing Protein 4 in Fc epsilon RI-mediated Signaling, Mast Cell Function, and T Cell Development
[作者:Zhu, MH; Fuller, DM; Zhang, WG,期刊:Journal of Biological Chemistry, 页码:8135-8143 , 文章类型: Article,,卷期:2012年287-11]
- The RasGRP (Ras guanine nucleotide-releasing protein) family proteins are guanine nucleotide exchange factors that activate Ras GTPases, ultimately leading to MAPK activation and many cellular processes. The RasGRP famil...
- The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine
[作者:Asada, R; Saito, A; Kawasaki, N; Kanemoto, S; Iwamoto, H; Oki, M; Miyagi, H; Izumi, S; Imaizumi, K,期刊:Journal of Biological Chemistry, 页码:8144-8153 , 文章类型: Article,,卷期:2012年287-11]
- OASIS is a basic leucine zipper transmembrane transcription factor localized in the endoplasmic reticulum (ER) that is cleaved in its transmembrane region in response to ER stress. This novel ER stress transducer has bee...
- Pyroglutamate Amyloid beta (A beta) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease
[作者:Wittnam, JL; Portelius, E; Zetterberg, H; Gustavsson, MK; Schilling, S; Koch, B; Demuth, HU; Blennow, K; Wirths, O; Bayer, TA,期刊:Journal of Biological Chemistry, 页码:8154-8162 , 文章类型: Article,,卷期:2012年287-11]
- Pyroglutamate-modified A beta peptides at amino acid position three (A beta(pE3-42)) are gaining considerable attention as potential key players in the pathogenesis of Alzheimer disease (AD). A beta(pE3-42) is abundant i...
- Functional Identification of Triterpene Methyltransferases from Botryococcus braunii Race B
[作者:Niehaus, TD; Kinison, S; Okada, S; Yeo, YS; Bell, SA; Cui, P; Devarenne, TP; Chappell, J,期刊:Journal of Biological Chemistry, 页码:8163-8173 , 文章类型: Article,,卷期:2012年287-11]
- Botryococcus braunii race B is a colony-forming, green algae that accumulates triterpene oils in excess of 30% of its dry weight. The composition of the triterpene oils is dominated by dimethylated to tetramethylated for...
- Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease EFFECTS ON MITOCHONDRIAL TRANSPORT
[作者:Matenia, D; Hempp, C; Timm, T; Eikhof, A; Mandelkow, EM,期刊:Journal of Biological Chemistry, 页码:8174-8186 , 文章类型: Article,,卷期:2012年287-11]
- The kinase MARK2/Par-1 plays key roles in several cell processes, including neurodegeneration such as Alzheimer disease by phosphorylating tau and detaching it from microtubules. In search of interaction partners of MARK...
- Net Proton Uptake Is Preceded by Multiple Proton Transfer Steps upon Electron Injection into Cytochrome c Oxidase
[作者:Kirchberg, K; Michel, H; Alexiev, U,期刊:Journal of Biological Chemistry, 页码:8187-8193 , 文章类型: Article,,卷期:2012年287-11]
- Cytochrome c oxidase (COX), the last enzyme of the respiratory chain of aerobic organisms, catalyzes the reduction of molecular oxygen to water. It is a redox-linked proton pump, whose mechanism of proton pumping has bee...
- Once Phosphorylated, Tyrosines in Carboxyl Terminus of Protein-tyrosine Kinase Syk Interact with Signaling Proteins, Including TULA-2, a Negative Regulator of Mast Cell Degranulation
[作者:de Castro, RO; Zhang, J; Groves, JR; Barbu, EA; Siraganian, RP,期刊:Journal of Biological Chemistry, 页码:8194-8204 , 文章类型: Article,,卷期:2012年287-11]
- Activation of the high affinity IgE-binding receptor (Fc epsilon RI) results in the tyrosine phosphorylation of two conserved tyrosines located close to the COOH terminus of the protein-tyrosine kinase Syk. Synthetic pep...
- Contradictory Functions (Activation/Termination) of Neutrophil Proteinase 3 Enzyme (PR3) in Interleukin-33 Biological Activity
[作者:Bae, S; Kang, T; Hong, J; Lee, S; Choi, J; Jhun, H; Kwak, A; Hong, K; Kim, E; Jo, S; Kim, S,期刊:Journal of Biological Chemistry, 页码:8205-8213 , 文章类型: Article,,卷期:2012年287-11]
- IL-1 family ligand does not possess a typical hydrophobic signal peptide and needs a processing enzyme for maturation. The maturation process of IL-33 (IL-1F11), a new member of the IL-1 family ligand, remains unclear. P...
- NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling
[作者:Lillehoj, EP; Hyun, SW; Feng, CG; Zhang, L; Liu, AG; Guang, W; Nguyen, C; Luzina, IG; Atamas, SP; Passaniti, A; Twaddell, WS; Puche, AC; Wang, LX; Cross, AS; Goldblum, SE,期刊:Journal of Biological Chemistry, 页码:8214-8231 , 文章类型: Article,,卷期:2012年287-11]
- Epithelial cells (ECs) lining the airways provide a protective barrier between the external environment and the internal host milieu. These same airway epithelia express receptors that respond to danger signals and initi...
- An Amino Acid Position at Crossroads of Evolution of Protein Function ANTIBIOTIC SENSOR DOMAIN OF BlaR1 PROTEIN FROM STAPHYLOCOCCUS AUREUS VERSUS CLASS D beta-LACTAMASES
[作者:Kumarasiri, M; Llarrull, LI; Borbulevych, O; Fishovitz, J; Lastochkin, E; Baker, BM; Mobashery, S,期刊:Journal of Biological Chemistry, 页码:8232-8241 , 文章类型: Article,,卷期:2012年287-11]
- The integral membrane protein BlaR1 of Staphylococcus aureus senses the presence of beta-lactam antibiotics in the milieu and transduces the information to its cytoplasmic side, where its activity unleashes the expressio...
- Ca2+-dependent GTPase, Extra-large G Protein 2 (XLG2), Promotes Activation of DNA-binding Protein Related to Vernalization 1 (RTV1), Leading to Activation of Floral Integrator Genes and Early Flowering in Arabidopsis
[作者:Heo, JB; Sung, S; Assmann, SM,期刊:Journal of Biological Chemistry, 页码:8242-8253 , 文章类型: Article,,卷期:2012年287-11]
- Heterotrimeric G proteins, consisting of G alpha, G beta, and G gamma sub-units, play important roles in plant development and cell signaling. In Arabidopsis, in addition to one prototypical G protein alpha subunit, GPA1...
- Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif A PARTIALLY FOLDED DOMAIN
[作者:Howarth, JW; Ramisetti, S; Nolan, K; Sadayappan, S; Rosevear, PR,期刊:Journal of Biological Chemistry, 页码:8254-8262 , 文章类型: Article,,卷期:2012年287-11]
- The structural role of the unique myosin-binding motif (m-domain) of cardiac myosin-binding protein-C remains unclear. Functionally, the m-domain is thought to directly interact with myosin, whereas phosphorylation of th...
- Identification of Residues That Underpin Interactions within the Eukaryotic Initiation Factor (eIF2) 2B Complex
[作者:Wang, XM; Wortham, NC; Liu, R; Proud, CG,期刊:Journal of Biological Chemistry, 页码:8263-8274 , 文章类型: Article,,卷期:2012年287-11]
- Eukaryotic initiation factor 2B (eIF2B) plays a key role in protein synthesis and in its control. It comprises five different subunits, alpha-epsilon, of which eIF2B epsilon contains the catalytic domain. Formation of th...
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