- Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability
[作者:Ashpole, NM; Song, WH; Brustovetsky, T; Engleman, EA; Brustovetsky, N; Cummins, TR; Hudmon, A,期刊:Journal of Biological Chemistry, 页码:8495-8506 , 文章类型: Article,,卷期:2012年287-11]
- Aberrant glutamate and calcium signalings are neurotoxic to specific neuronal populations. Calcium/calmodulin-dependent kinase II (CaMKII), a multifunctional serine/threonine protein kinase in neurons, is believed to reg...
- Biochemical Characterization of Ribosome Assembly GTPase RbgA in Bacillus subtilis
[作者:Achila, D; Gulati, M; Jain, N; Britton, RA,期刊:Journal of Biological Chemistry, 页码:8417-8423 , 文章类型: Article,,卷期:2012年287-11]
- The ribosome biogenesis GTPase A protein RbgA is involved in the assembly of the large ribosomal subunit in Bacillus subtilis, and homologs of RbgA are implicated in the biogenesis of mitochondrial, chloroplast, and cyto...
- Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
[作者:Seeliger, JC; Holsclaw, CM; Schelle, MW; Botyanszki, Z; Gilmore, SA; Tully, SE; Niederweis, M; Cravatt, BF; Leary, JA; Bertozzi, CR,期刊:Journal of Biological Chemistry, 页码:7990-8000 , 文章类型: Article,,卷期:2012年287-11]
- Mycobacterium tuberculosis possesses unique cell-surface lipids that have been implicated in virulence. One of the most abundant is sulfolipid-1 (SL-1), a tetraacyl-sulfotrehalose glycolipid. Although the early steps in ...
- Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity
[作者:Pruitt, RN; Chumbler, NM; Rutherford, SA; Farrow, MA; Friedman, DB; Spiller, B; Lacy, DB,期刊:Journal of Biological Chemistry, 页码:8013-8020 , 文章类型: Article,,卷期:2012年287-11]
- The principle virulence factors in Clostridium difficile pathogenesis are TcdA and TcdB, homologous glucosyltransferases capable of inactivating small GTPases within the host cell. We present crystal structures of the Tc...
- Preparation of Site-specific T = (m)CG cis-syn Cyclobutane Dimer-containing Template and Its Error-free Bypass by Yeast and Human Polymerase eta
[作者:Song, Q; Sherrer, SM; Suo, ZC; Taylor, JS,期刊:Journal of Biological Chemistry, 页码:8021-8028 , 文章类型: Article,,卷期:2012年287-11]
- C-to-T mutations are a hallmark of UV light and, in humans, occur preferentially at methylated Py(m)CG sites, which are also sites of preferential cyclobutane pyrimidine dimer (CPD) formation. In response, cells have evo...
- Molecular Determinants of Proteolytic Disassembly of the Reovirus Outer Capsid
[作者:Doyle, JD; Danthi, P; Kendall, EA; Ooms, LS; Wetzel, JD; Dermody, TS,期刊:Journal of Biological Chemistry, 页码:8029-8038 , 文章类型: Article,,卷期:2012年287-11]
- Following attachment and internalization, mammalian reoviruses undergo intracellular proteolytic disassembly followed by viral penetration into the cytoplasm. The initiating event in reovirus disassembly is the cathepsin...
- Structural Insights into Charge Pair Interactions in Triple Helical Collagen-like Proteins
[作者:Fallas, JA; Dong, JH; Tao, YZJ; Hartgerink, JD,期刊:Journal of Biological Chemistry, 页码:8039-8047 , 文章类型: Article,,卷期:2012年287-11]
- The collagen triple helix is the most abundant protein fold in humans. Despite its deceptively simple structure, very little is understood about its folding and fibrillization energy landscape. In this work, using a comb...
- Met Kinase-dependent Loss of the E3 Ligase Cbl in Gastric Cancer
[作者:Lai, AZ; Durrant, M; Zuo, DM; Ratcliffe, CDH; Park, M,期刊:Journal of Biological Chemistry, 页码:8048-8059 , 文章类型: Article,,卷期:2012年287-11]
- Strict regulation of signaling by receptor tyrosine kinases (RTKs) is essential for normal biological processes, and disruption of this regulation can lead to tumor initiation and progression. Signal duration by the Met ...
- Inhibin alpha-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling
[作者:Zhu, J; Lin, SJ; Zou, C; Makanji, Y; Jardetzky, TS; Woodruff, TK,期刊:Journal of Biological Chemistry, 页码:8060-8070 , 文章类型: Article,,卷期:2012年287-11]
- Inhibin is a heterodimeric peptide hormone produced in the ovary that antagonizes activin signaling and FSH synthesis in the pituitary. The inhibin beta-subunit interacts with the activin type II receptor (ActRII) to fun...
- Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis
[作者:Colletti, GA; Miedel, MT; Quinn, J; Andharia, N; Weisz, OA; Kiselyov, K,期刊:Journal of Biological Chemistry, 页码:8082-8091 , 文章类型: Article,,卷期:2012年287-11]
- Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the gene MCOLN1, which codes for the transient receptor potential family ion channel TRPML1. MLIV has an early onset and is characterized...
- PRELP Protein Inhibits the Formation of the Complement Membrane Attack Complex
[作者:Happonen, KE; Furst, CM; Saxne, T; Heinegard, D; Blom, AM,期刊:Journal of Biological Chemistry, 页码:8092-8100 , 文章类型: Article,,卷期:2012年287-11]
- PRELP is a 58-kDa proteoglycan found in a variety of extracellular matrices, including cartilage and at several basement membranes. In rheumatoid arthritis (RA), the cartilage tissue is destroyed and fragmented molecules...
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