- Augmentation of Kv4.2-encoded Currents by Accessory Dipeptidyl Peptidase 6 and 10 Subunits Reflects Selective Cell Surface Kv4.2 Protein Stabilization
[作者:Foeger, NC; Norris, AJ; Wren, LM; Nerbonne, JM,期刊:Journal of Biological Chemistry, 页码:9640-9650 , 文章类型: Article,,卷期:2012年287-12]
- Rapidly activating and inactivating somatodendritic voltage-gated K+ (Kv) currents, I-A, play critical roles in the regulation of neuronal excitability. Considerable evidence suggests that native neuronal I-A channels fu...
- Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
[作者:Romero-Ruiz, A; Bautista, L; Navarro, V; Heras-Garvin, A; March-Diaz, R; Castellano, A; Gomez-Diaz, R; Castro, MJ; Berra, E; Lopez-Barneo, J; Pascual, A,期刊:Journal of Biological Chemistry, 页码:9651-9658 , 文章类型: Article,,卷期:2012年287-12]
- Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly known. We have studied the post-transcriptional changes in the proteome of mammalian cells elicit...
- Mapping of the Localization of Type 1 Angiotensin Receptor in Membrane Microdomains Using Bioluminescence Resonance Energy Transfer-based Sensors
[作者:Balla, A; Toth, DJ; Soltesz-Katona, E; Szakadati, G; Erdelyi, LS; Varnai, P; Hunyady, L,期刊:Journal of Biological Chemistry, 页码:9090-9099 , 文章类型: Article,,卷期:2012年287-12]
- Initiation and termination of signaling of the type I angiotensin receptor (AT(1)-R) can lead to dynamic changes in its localization in plasma membrane microdomains. Several markers were recently developed to investigate...
- NT-PGC-1 alpha Protein Is Sufficient to Link beta(3)-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis
[作者:Chang, JS; Fernand, V; Zhang, YB; Shin, J; Jun, HJ; Joshi, Y; Gettys, TW,期刊:Journal of Biological Chemistry, 页码:9100-9111 , 文章类型: Article,,卷期:2012年287-12]
- PGC-1 alpha is an inducible transcriptional coactivator that regulates cellular energy metabolism and adaptation to environmental and nutritional stimuli. In tissues expressing PGC-1 alpha, alternative splicing produces ...
- Cytosolic Bax DOES IT REQUIRE BINDING PROTEINS TO KEEP ITS PRO-APOPTOTIC ACTIVITY IN CHECK?
[作者:Vogel, S; Raulf, N; Bregenhorn, S; Biniossek, ML; Maurer, U; Czabotar, P; Borner, C,期刊:Journal of Biological Chemistry, 页码:9112-9127 , 文章类型: Article,,卷期:2012年287-12]
- Bax is kept inactive in the cytosol by refolding its C-terminal transmembrane domain into the hydrophobic binding pocket. Although energetic calculations predicted this conformation to be stable, numerous Bax binding pro...
- Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair
[作者:Li, XX; Liu, KX; Li, FD; Wang, JC; Huang, HD; Wu, JH; Shi, YY,期刊:Journal of Biological Chemistry, 页码:9137-9146 , 文章类型: Article,,卷期:2012年287-12]
- Rtt107 (regulator of Ty1 transposition 107; Esc4) is a DNA repair protein from Saccharomyces cerevisiae that can restore stalled replication forks following DNA damage. There are six BRCT (BRCA1 C-terminal) domains in Rt...
- Serine/Threonine Phosphatase (SP-STP), Secreted from Streptococcus pyogenes, Is a Pro-apoptotic Protein
[作者:Agarwal, S; Agarwal, S; Jin, H; Pancholi, P; Pancholi, V,期刊:Journal of Biological Chemistry, 页码:9147-9167 , 文章类型: Article,,卷期:2012年287-12]
- This investigation illustrates an important property of eukaryote-type serine/threonine phosphatase (SP-STP) of group A Streptococcus (GAS) in causing programmed cell death of human pharyngeal cells. The secretory nature...
- Curcumin Prevents Aggregation in alpha-Synuclein by Increasing Reconfiguration Rate
[作者:Ahmad, B; Lapidus, LJ,期刊:Journal of Biological Chemistry, 页码:9193-9199 , 文章类型: Article,,卷期:2012年287-12]
- alpha-Synuclein is a protein that is intrinsically disordered in vitro and prone to aggregation, particularly at high temperatures. In this work, we examined the ability of curcumin, a compound found in turmeric, to prev...
- Ligand-dependent Corepressor (LCoR) Recruitment by Kruppel-like Factor 6 (KLF6) Regulates Expression of the Cyclin-dependent Kinase Inhibitor CDKN1A Gene
[作者:Calderon, MR; Verway, M; An, BS; Difeo, A; Bismar, TA; Ann, DK; Martignetti, JA; Shalom-Barak, T; White, JH,期刊:Journal of Biological Chemistry, 页码:8662-8674 , 文章类型: Article,,卷期:2012年287-12]
- The widely expressed transcriptional coregulator, ligand-dependent corepressor (LCoR), initially characterized as a regulator of nuclear receptor-mediated transactivation, functions through recruitment of C-terminal bind...
- Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin
[作者:Karst, JC; Barker, R; Devi, U; Swann, MJ; Davi, M; Roser, SJ; Ladant, D; Chenal, A,期刊:Journal of Biological Chemistry, 页码:9200-9212 , 文章类型: Article,,卷期:2012年287-12]
- The adenylate cyclase (CyaA) toxin, one of the virulence factors secreted by Bordetella pertussis, the pathogenic bacteria responsible for whooping cough, plays a critical role in the early stages of respiratory tract co...
- Functional Association of Catalytic and Ancillary Modules Dictates Enzymatic Activity in Glycoside Hydrolase Family 43 beta-Xylosidase
[作者:Morais, S; Salama-Alber, O; Barak, Y; Hadar, Y; Wilson, DB; Lamed, R; Shoham, Y; Bayer, EA,期刊:Journal of Biological Chemistry, 页码:9213-9221 , 文章类型: Article,,卷期:2012年287-12]
- beta-Xylosidases are hemicellulases that hydrolyze short xylo-oligosaccharides into xylose units, thus complementing endoxylanase degradation of the hemicellulose component of lignocellulosic substrates. Here, we describ...
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