- Glutathione Degradation by the Alternative Pathway (DUG Pathway) in Saccharomyces cerevisiae Is Initiated by (Dug2p-Dug3p)(2) Complex, a Novel Glutamine Amidotransferase (GATase) Enzyme Acting on Glutathione
[作者:Kaur, H; Ganguli, D; Bachhawat, AK,期刊:Journal of Biological Chemistry, 页码:8920-8931 , 文章类型: Article,,卷期:2012年287-12]
- The recently identified, fungi-specific alternative pathway of glutathione degradation requires the participation of three genes, DUG1, DUG2, and DUG3. Dug1p has earlier been shown to function as a Cys-Gly-specific dipep...
- Sometimes It Takes Two to Tango CONTRIBUTIONS OF DIMERIZATION TO FUNCTIONS OF HUMAN alpha-DEFENSIN HNP1 PEPTIDE
[作者:Pazgier, M; Wei, G; Ericksen, B; Jung, G; Wu, ZB; de Leeuw, E; Yuan, WR; Szmacinski, H; Lu, WY; Lubkowski, J; Lehrer, RI; Lu, WY,期刊:Journal of Biological Chemistry, 页码:8944-8953 , 文章类型: Article,,卷期:2012年287-12]
- Human myeloid alpha-defensins called HNPs play multiple roles in innate host defense. The Trp-26 residue of HNP1 was previously shown to contribute importantly to its ability to kill S. aureus, inhibit anthrax lethal fac...
- Structural and Functional Characterization of Bc28.1, Major Erythrocyte-binding Protein from Babesia canis Merozoite Surface
[作者:Yang, YS; Murciano, B; Moubri, K; Cibrelus, P; Schetters, T; Gorenflot, A; Delbecq, S; Roumestand, C,期刊:Journal of Biological Chemistry, 页码:9495-9508 , 文章类型: Article,,卷期:2012年287-12]
- Babesiosis (formerly known as piroplasmosis) is a tick-borne disease caused by the intraerythrocytic development of protozoa parasites from the genus Babesia. Like Plasmodium falciparum, the agent of malaria, or Toxoplas...
- Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire
[作者:van Lummel, M; van Veelen, PA; Zaldumbide, A; de Ru, A; Janssen, GMC; Moustakas, AK; Papadopoulos, GK; Drijfhout, JW; Roep, BO; Koning, F,期刊:Journal of Biological Chemistry, 页码:9514-9524 , 文章类型: Article,,卷期:2012年287-12]
- HLA-DQ2 and HLA-DQ8 are strongly predisposing haplotypes for type 1 diabetes (T1D). Yet HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with HLA-DQ2 or HLA-DQ8 homozygote subjects that m...
- Lipid Polarity Is Maintained in Absence of Tight Junctions
[作者:Ikenouchi, J; Suzuki, M; Umeda, K; Ikeda, K; Taguchi, R; Kobayashi, T; Sato, SB; Kobayashi, T; Stolz, DB; Umeda, M,期刊:Journal of Biological Chemistry, 页码:9525-9533 , 文章类型: Article,,卷期:2012年287-12]
- The role of tight junctions (TJs) in the establishment and maintenance of lipid polarity in epithelial cells has long been a subject of controversy. We have addressed this issue using lysenin, a toxin derived from earthw...
- Small GTPase Rab17 Regulates Dendritic Morphogenesis and Postsynaptic Development of Hippocampal Neurons
[作者:Mori, Y; Matsui, T; Furutani, Y; Yoshihara, Y; Fukuda, M,期刊:Journal of Biological Chemistry, 页码:8963-8973 , 文章类型: Article,,卷期:2012年287-12]
- Neurons are compartmentalized into two morphologically, molecularly, and functionally distinct domains: axons and dendrites, and precise targeting and localization of proteins within these domains are critical for proper...
- Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor
[作者:Punn, A; Chen, J; Delidaki, M; Tang, JY; Liapakis, G; Lehnert, H; Levine, MA; Grammatopoulos, DK,期刊:Journal of Biological Chemistry, 页码:8974-8985 , 文章类型: Article,,卷期:2012年287-12]
- The type 1 corticotropin-releasing hormone receptor (CRH-R1) influences biological responses important for adaptation to stressful stimuli, through activation of multiple downstream effectors. The structural motifs withi...
- Paramecium bursaria Chlorella Virus 1 Encodes a Polyamine Acetyltransferase
[作者:Charlop-Powers, Z; Jakoncic, J; Gurnon, JR; Van Etten, JL; Zhou, MM,期刊:Journal of Biological Chemistry, 页码:9547-9551 , 文章类型: Article,,卷期:2012年287-12]
- Paramecium bursaria chlorella virus 1 (PBCV-1), a large DNA virus that infects green algae, encodes a histone H3 lysine 27-specific methyltransferase that functions in global transcriptional silencing of the host. PBCV-1...
- Absence of Post-phosphoryl Modification in Dystroglycanopathy Mouse Models and Wild-type Tissues Expressing Non-laminin Binding Form of alpha-Dystroglycan
[作者:Kuga, A; Kanagawa, M; Sudo, A; Chan, YM; Tajiri, M; Manya, H; Kikkawa, Y; Nomizu, M; Kobayashi, K; Endo, T; Lu, QL; Wada, Y; Toda, T,期刊:Journal of Biological Chemistry, 页码:9560-9567 , 文章类型: Article,,卷期:2012年287-12]
- alpha-Dystroglycan (alpha-DG) is a membrane-associated glycoprotein that interacts with several extracellular matrix proteins, including laminin and agrin. Aberrant glycosylation of alpha-DG disrupts its interaction with...
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