- HSP90 and HSP70 Proteins Are Essential for Stabilization and Activation of WASF3 Metastasis-promoting Protein
[作者:Teng, Y; Ngoka, L; Mei, Y; Lesoon, L; Cowell, JK,期刊:Journal of Biological Chemistry, 页码:10051-10059 , 文章类型: Article,,卷期:2012年287-13]
- Inactivation of HSP90 and HSP70 leads to loss of invasion in a variety of cancer cell types, presumably as a result of destabilization of, as yet, undefined clients of these molecular chaperones that influence this pheno...
- Pattern Recognition Protein Binds to Lipopolysaccharide and beta-1,3-Glucan and Activates Shrimp Prophenoloxidase System
[作者:Amparyup, P; Sutthangkul, J; Charoensapsri, W; Tassanakajon, A,期刊:Journal of Biological Chemistry, 页码:10060-10069 , 文章类型: Article,,卷期:2012年287-13]
- The prophenoloxidase (proPO) system is activated upon recognition of pathogens by pattern recognition proteins (PRPs), including a lipopolysaccharide-and beta-1,3-glucan-bindingprotein (LGBP). However, shrimp LGBPs that ...
- Ringo/Cyclin-dependent Kinase and Mitogen-activated Protein Kinase Signaling Pathways Regulate the Activity of the Cell Fate Determinant Musashi to Promote Cell Cycle Re-entry in Xenopus Oocytes
[作者:Arumugam, K; MacNicol, MC; Wang, YY; Cragle, CE; Tackett, AJ; Hardy, LL; MacNicol, AM,期刊:Journal of Biological Chemistry, 页码:10639-10649 , 文章类型: Article,,卷期:2012年287-13]
- Cell cycle re-entry during vertebrate oocyte maturation is mediated through translational activation of select target mRNAs, culminating in the activation of mitogen-activated protein kinase and cyclin B/cyclin-dependent...
- Transient P2X(7) Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins
[作者:Hanley, PJ; Kronlage, M; Kirschning, C; del Rey, A; Di Virgilio, F; Leipziger, J; Chessell, IP; Sargin, S; Filippov, MA; Lindemann, O; Mohr, S; Konigs, V; Schillers, H; Bahler, M; Schwab, A,期刊:Journal of Biological Chemistry, 页码:10650-10663 , 文章类型: Article,,卷期:2012年287-13]
- The function of P2X(7) receptors (ATP-gated ion channels) in innate immune cells is unclear. In the setting of Toll-like receptor (TLR) stimulation, secondary activation of P2X(7) ion channels has been linked to pro-casp...
- Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex
[作者:Jin, ZN; Leveque, V; Ma, H; Johnson, KA; Klumpp, K,期刊:Journal of Biological Chemistry, 页码:10674-10683 , 文章类型: Article,,卷期:2012年287-13]
- NS5B is the RNA-dependent RNA polymerase responsible for replicating hepatitis C virus (HCV) genomic RNA. Despite more than a decade of work, the formation of a highly active NS5B polymerase.RNA complex suitable for mech...
- Human Protein N-terminal Acetyltransferase hNaa50p (hNAT5/hSAN) Follows Ordered Sequential Catalytic Mechanism COMBINED KINETIC AND NMR STUDY
[作者:Evjenth, RH; Brenner, AK; Thompson, PR; Arnesen, T; Froystein, NA; Lillehaug, JR,期刊:Journal of Biological Chemistry, 页码:10081-10088 , 文章类型: Article,,卷期:2012年287-13]
- N-alpha-Acetylation is a common protein modification catalyzed by different N-terminal acetyltransferases (NATs). Their essential role in the biogenesis and degradation of proteins is becoming increasingly evident. TheNA...
- Identification and Characterization of Nardilysin as a Novel Dimethyl H3K4-binding Protein Involved in Transcriptional Regulation
[作者:Li, J; Chu, MY; Wang, SS; Chan, D; Qi, SK; Wu, M; Zhou, ZL; Li, JW; Nishi, E; Qin, J; Wong, JM,期刊:Journal of Biological Chemistry, 页码:10089-10098 , 文章类型: Article,,卷期:2012年287-13]
- Histone methylation on lysine residues is believed to function primarily as docking sites to recruit specific proteins termed as histone code "readers" or "effectors." Each lysine residue can be mono-, di, and tri-methyl...
- Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity
[作者:Plantier, L; Besnard, V; Xu, Y; Ikegami, M; Wert, SE; Hunt, AN; Postle, AD; Whitsett, JA,期刊:Journal of Biological Chemistry, 页码:10099-10114 , 文章类型: Article,,卷期:2012年287-13]
- Pulmonary inflammation is associated with altered lipid synthesis and clearance related to diabetes, obesity, and various inherited metabolic disorders. In many tissues, lipogenesis is regulated at the transcriptional le...
- Multiple Forms of Spire-Actin Complexes and their Functional Consequences
[作者:Chen, CK; Sawaya, MR; Phillips, ML; Reisler, E; Quinlan, ME,期刊:Journal of Biological Chemistry, 页码:10684-10692 , 文章类型: Article,,卷期:2012年287-13]
- Spire is a WH2 domain-containing actin nucleator essential for establishing an actin mesh during oogenesis. In vitro, in addition to nucleating filaments, Spire can sever them and sequester actin monomers. Understanding ...
- MUC1-C Oncoprotein Induces TCF7L2 Transcription Factor Activation and Promotes Cyclin D1 Expression in Human Breast Cancer Cells
[作者:Rajabi, H; Ahmad, R; Jin, CN; Kosugi, M; Alam, M; Joshi, MD; Kufe, D,期刊:Journal of Biological Chemistry, 页码:10703-10713 , 文章类型: Article,,卷期:2012年287-13]
- MUC1 is a heterodimeric glycoprotein that is overexpressed in breast cancers. The present studies demonstrate that the oncogenic MUC1 C-terminal subunit (MUC1-C) associates with the TCF7L2 transcription factor. The MUC1-...
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