- Loss of Brain-enriched miR-124 MicroRNA Enhances Stem-like Traits and Invasiveness of Glioma Cells
[作者:Xia, HP; Cheung, WKC; Ng, SS; Jiang, XC; Jiang, SS; Sze, J; Leung, GKK; Lu, G; Chan, DTM; Bian, XW; Kung, HF; Poon, WS; Lin, MC,期刊:Journal of Biological Chemistry, 页码:9962-9971 , 文章类型: Article,,卷期:2012年287-13]
- miR-124 is a brain-enriched microRNA that plays a crucial role in neural development and has been shown to be down-regulated in glioma and medulloblastoma, suggesting its possible involvement in brain tumor progression. ...
- Contribution of Host Nucleoporin 62 in HIV-1 Integrase Chromatin Association and Viral DNA Integration
[作者:Ao, ZJ; Jayappa, KD; Wang, BC; Zheng, YF; Wang, XX; Peng, JY; Yao, XJ,期刊:Journal of Biological Chemistry, 页码:10544-10555 , 文章类型: Article,,卷期:2012年287-13]
- HIV-1 integration is promoted by viral integrase (IN) and its cellular cofactors. The lens epithelium-derived growth factor (LEDGF/p75), an IN interacting cellular cofactor, has been shown to play an important role in HI...
- Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells
[作者:Yeang, HXA; Hamdam, JM; Al-Huseini, LMA; Sethu, S; Djouhri, L; Walsh, J; Kitteringham, N; Park, BK; Goldring, CE; Sathish, JG,期刊:Journal of Biological Chemistry, 页码:10556-10564 , 文章类型: Article,,卷期:2012年287-13]
- Dendritic cells (DCs) are critical mediators of immunity and immune tolerance by orchestrating multiple aspects of T cell activation and function. Immature DCs (iDCs) expressing low levels of co-stimulatory receptors are...
- Phospholipase C-related but Catalytically Inactive Protein (PRIP) Modulates Synaptosomal-associated Protein 25 (SNAP-25) Phosphorylation and Exocytosis
[作者:Gao, J; Takeuchi, H; Zhang, Z; Fukuda, M; Hirata, M,期刊:Journal of Biological Chemistry, 页码:10565-10578 , 文章类型: Article,,卷期:2012年287-13]
- Exocytosis is one of the most fundamental cellular events. The basic mechanism of the final step, membrane fusion, is mediated by the formation of the SNARE complex, which is modulated by the phosphorylation of proteins ...
- Mutated Major Histocompatibility Complex Class II Transactivator Up-regulates Interleukin-33-dependent Differentiation of Th2 Subset through Nod2 Binding for NLR (NOD-like Receptor) Signaling Initiation
[作者:Yang, ZQ; Gu, P; Shao, XY; Li, ZQ; Zhou, Y; Lu, LM; Chou, KY,期刊:Journal of Biological Chemistry, 页码:9972-9981 , 文章类型: Article,,卷期:2012年287-13]
- Dominant-negative mutants of class II transactivator (mCIITAs) with N-terminal depletion have been used to repress the transcription of class II genes in xenotransplantation. Here, we report that mCIITA overexpressing my...
- Role of Metalloproteases in Vaccinia Virus Epitope Processing for Transporter Associated with Antigen Processing (TAP)-independent Human Leukocyte Antigen (HLA)-B7 Class I Antigen Presentation
[作者:Lorente, E; Garcia, R; Mir, C; Barriga, A; Lemonnier, FA; Ramos, M; Lopez, D,期刊:Journal of Biological Chemistry, 页码:9990-10000 , 文章类型: Article,,卷期:2012年287-13]
- The transporter associated with antigen processing (TAP) translocates the viral proteolytic peptides generated by the proteasome and other proteases in the cytosol to the endoplasmic reticulum lumen. There, they complex ...
- Role of Epithelial-Stem Cell Interactions during Dental Cell Differentiation
[作者:Arakaki, M; Ishikawa, M; Nakamura, T; Iwamoto, T; Yamada, A; Fukumoto, E; Saito, M; Otsu, K; Harada, H; Yamada, Y; Fukumoto, S,期刊:Journal of Biological Chemistry, 页码:10590-10601 , 文章类型: Article,,卷期:2012年287-13]
- Epithelial-mesenchymal interactions regulate the growth and morphogenesis of ectodermal organs such as teeth. Dental pulp stem cells (DPSCs) are a part of dental mesenchyme, derived from the cranial neural crest, and dif...
- Bivalent Carbohydrate Binding Is Required for Biological Activity of Clitocybe nebularis Lectin (CNL), the N, N '-Diacetyllactosediamine (GalNAc beta 1-4GlcNAc, LacdiNAc)-specific Lectin from Basidiomycete C. nebularis
[作者:Pohleven, J; Renko, M; Magister, S; Smith, DF; Kunzler, M; Strukelj, B; Turk, D; Kos, J; Sabotic, J,期刊:Journal of Biological Chemistry, 页码:10602-10612 , 文章类型: Article,,卷期:2012年287-13]
- Lectins are carbohydrate-binding proteins that exert their biological activity by binding to specific cell glycoreceptors. We have expressed CNL, a ricin B-like lectin from the basidiomycete Clitocybe nebularis in Escher...
- Ubiquitin- and MDM2 E3 Ligase-independent Proteasomal Turnover of Nucleostemin in Response to GTP Depletion
[作者:Lo, D; Dai, MS; Sun, XX; Zeng, SX; Lu, H,期刊:Journal of Biological Chemistry, 页码:10013-10020 , 文章类型: Article,,卷期:2012年287-13]
- Nucleostemin (NS) is a nucleolar GTP-binding protein essential for ribosomal biogenesis, proliferation, and animal embryogenesis. It remains largely unclear how this protein is regulated. While working on its role in sup...
- Nrf2-dependent Induction of Proteasome and Pa28 alpha beta Regulator Are Required for Adaptation to Oxidative Stress
[作者:Pickering, AM; Linder, RA; Zhang, HQ; Forman, HJ; Davies, KJA,期刊:Journal of Biological Chemistry, 页码:10021-10031 , 文章类型: Article,,卷期:2012年287-13]
- The ability to adapt to acute oxidative stress (e.g. H2O2, peroxynitrite, menadione, and paraquat) through transient alterations in gene expression is an important component of cellular defense mechanisms. We show that s...
- Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants
[作者:Zhao, B; Lei, L; Kagawa, N; Sundaramoorthy, M; Banerjee, S; Nagy, LD; Guengerich, FP; Waterman, MR,期刊:Journal of Biological Chemistry, 页码:10613-10622 , 文章类型: Article,,卷期:2012年287-13]
- Steroid 21-hydroxylase (cytochrome P450 21A2, CYP21A2) deficiency accounts for similar to 95% of individuals with congenital adrenal hyperplasia, a common autosomal recessive metabolic disorder of adrenal steroidogenesis...
- Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy
[作者:Kondo-Okamoto, N; Noda, NN; Suzuki, SW; Nakatogawa, H; Takahashi, I; Matsunami, M; Hashimoto, A; Inagaki, F; Ohsumi, Y; Okamoto, K,期刊:Journal of Biological Chemistry, 页码:10631-10638 , 文章类型: Article,,卷期:2012年287-13]
- Autophagy-related degradation selective for mitochondria (mitophagy) is an evolutionarily conserved process that is thought to be critical for mitochondrial quality and quantity control. In budding yeast, autophagy-relat...
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