- The Transmembrane Prolines of the Mitochondrial ADP/ATP Carrier Are Involved in Nucleotide Binding and Transport and Its Biogenesis
[作者:Babot, M; Blancard, C; Pelosi, L; Lauquin, GJM; Trezeguet, V,期刊:Journal of Biological Chemistry, 页码:10368-10378 , 文章类型: Article,,卷期:2012年287-13]
- The mitochondrial ADP/ATP carrier (Ancp) is a paradigm of the mitochondrial carrier family, which allows cross-talk between mitochondria, where cell energy is mainly produced, and cytosol, where cell energy is mainly con...
- The Cell Surface Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Contributes to Epidermal Growth Factor Receptor-mediated Cell Migration
[作者:Dong, Y; He, YW; de Boer, L; Stack, MS; Lumley, JW; Clements, JA; Hooper, JD,期刊:Journal of Biological Chemistry, 页码:9792-9803 , 文章类型: Article,,卷期:2012年287-13]
- Epidermal growth factor (EGF) activation of the EGF receptor (EGFR) is an important mediator of cell migration, and aberrant signaling via this system promotes a number of malignancies including ovarian cancer. We have i...
- Transport of Influenza Virus Neuraminidase (NA) to Host Cell Surface Is Regulated by ARHGAP21 and Cdc42 Proteins
[作者:Wang, S; Li, H; Chen, YH; Wei, HT; Gao, GF; Liu, HQ; Huang, SL; Chen, JL,期刊:Journal of Biological Chemistry, 页码:9804-9816 , 文章类型: Article,,卷期:2012年287-13]
- Influenza virus neuraminidase (NA) is transported to the virus assembly site at the plasma membrane and is a major viral envelope component that plays a critical role in the release of progeny virions and in determinatio...
- MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
[作者:Yin, HQ; Hu, M; Zhang, R; Shen, Z; Flatow, L; You, M,期刊:Journal of Biological Chemistry, 页码:9817-9826 , 文章类型: Article,,卷期:2012年287-13]
- Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying mechanisms of this inhibition by identifying a new ...
- Transcription Factor GATA4 Is Activated but Not Required for Insulin-like Growth Factor 1 (IGF1)-induced Cardiac Hypertrophy
[作者:Bisping, E; Ikeda, S; Sedej, M; Wakula, P; McMullen, JR; Tarnavski, O; Sedej, S; Izumo, S; Pu, WT; Pieske, B,期刊:Journal of Biological Chemistry, 页码:9827-9834 , 文章类型: Article,,卷期:2012年287-13]
- Insulin-like growth factor 1 (IGF1) promotes a physiological type of cardiac hypertrophy and has therapeutic effects in heart disease. Here, we report the relationship of IGF1 to GATA4, an essential transcription factor ...
- NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes
[作者:Han, CY; Umemoto, T; Omer, M; Den Hartigh, LJ; Chiba, T; Leboeuf, R; Buller, CL; Sweet, IR; Pennathur, S; Abel, ED; Chait, A,期刊:Journal of Biological Chemistry, 页码:10379-10393 , 文章类型: Article,,卷期:2012年287-13]
- Excess glucose and free fatty acids delivered to adipose tissue causes local inflammation, which contributes to insulin resistance. Glucose and palmitate generate reactive oxygen species (ROS) in adipocytes, leading to m...
- Identification of NIPSNAP1 as a Nocistatin-interacting Protein Involving Pain Transmission
[作者:Okuda-Ashitaka, E; Minami, T; Tsubouchi, S; Kiyonari, H; Iwamatsu, A; Noda, T; Handa, H; Ito, S,期刊:Journal of Biological Chemistry, 页码:10403-10413 , 文章类型: Article,,卷期:2012年287-13]
- 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a molecule of physiologically unknown function, although it is predominantly expressed in the brain, spinal cord, liver, and ki...
- Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21
[作者:Masgras, I; Carrera, S; de Verdier, PJ; Brennan, P; Majid, A; Makhtar, W; Tulchinsky, E; Jones, GDD; Roninson, IB; Macip, S,期刊:Journal of Biological Chemistry, 页码:9845-9854 , 文章类型: Article,,卷期:2012年287-13]
- p21(Waf1/Cip1/Sdi1) is a cyclin-dependent kinase inhibitor that mediates cell cycle arrest. Prolonged p21 up-regulation induces a senescent phenotype in normal and cancer cells, accompanied by an increase in intracellula...
- Crystal Structure of Mitochondrial Fission Complex Reveals Scaffolding Function for Mitochondrial Division 1 (Mdv1) Coiled Coil
[作者:Zhang, Y; Chan, NC; Ngo, HB; Gristick, H; Chan, DC,期刊:Journal of Biological Chemistry, 页码:9855-9861 , 文章类型: Article,,卷期:2012年287-13]
- The mitochondrial fission machinery is best understood in the yeast Saccharomyces cerevisiae, where Fis1, Mdv1, and Dnm1 are essential components. Fis1 is a mitochondrial outer membrane protein that recruits the dynamin-...
- Lack of Plakoglobin in Epidermis Leads to Keratoderma
[作者:Li, DQ; Zhang, WJ; Liu, Y; Haneline, LS; Shou, WN,期刊:Journal of Biological Chemistry, 页码:10435-10443 , 文章类型: Article,,卷期:2012年287-13]
- Loss-of-function mutation of Jup has been associated with Naxos disease, which is characterized by arrhythmogenic cardiomyopathy and the cutaneous disorder palmoplantar keratoderma. Previously, we have shown that genetic...
- Stabilization of RNT-1 Protein, Runt-related Transcription Factor (RUNX) Protein Homolog of Caenorhabditis elegans, by Oxidative Stress through Mitogen-activated Protein Kinase Pathway
[作者:Lee, K; Shim, J; Bae, J; Kim, YJ; Lee, J,期刊:Journal of Biological Chemistry, 页码:10444-10452 , 文章类型: Article,,卷期:2012年287-13]
- RUNX proteins are evolutionarily conserved transcription factors known to be involved in various developmental processes. Here we report a new role for a RUNX protein: a role in stress response. We show that RNT-1, the C...
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