- Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound
[作者:Wang, A; Savas, U; Hsu, MH; Stout, CD; Johnson, EF,期刊:Journal of Biological Chemistry, 页码:10834-10843 , 文章类型: Article,,卷期:2012年287-14]
- Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor, prinomastat, to 2.85 an...
- Mutant Protein A30P alpha-Synuclein Adopts Wild-type Fibril Structure, Despite Slower Fibrillation Kinetics
[作者:Lemkau, LR; Comellas, G; Kloepper, KD; Woods, WS; George, JM; Rienstra, CM,期刊:Journal of Biological Chemistry, 页码:11526-11532 , 文章类型: Article,,卷期:2012年287-14]
- alpha-Synuclein (AS) is associated with both sporadic and familial forms of Parkinson disease (PD). In sporadic disease, wild-type AS fibrillates and accumulates as Lewy bodies within dopaminergic neurons of the substant...
- Adaptor Protein Cerebral Cavernous Malformation 3 (CCM3) Mediates Phosphorylation of the Cytoskeletal Proteins Ezrin/Radixin/Moesin by Mammalian Ste20-4 to Protect Cells from Oxidative Stress
[作者:Fidalgo, M; Guerrero, A; Fraile, M; Iglesias, C; Pombo, CM; Zalvide, J,期刊:Journal of Biological Chemistry, 页码:11556-11565 , 文章类型: Article,,卷期:2012年287-14]
- While studying the functions of CCM3/PDCD10, a gene encoding an adaptor protein whose mutation results in vascular malformations, we have found that it is involved in a novel response to oxidative stress that results in ...
- Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells
[作者:Forsberg, M; Holmborn, K; Kundu, S; Dagalv, A; Kjellen, L; Forsberg-Nilsson, K,期刊:Journal of Biological Chemistry, 页码:10853-10862 , 文章类型: Article,,卷期:2012年287-14]
- Heparan sulfate proteoglycans, present on cell surfaces and in the extracellular matrix, interact with growth factors and morphogens to influence growth and differentiation of cells. The sulfation pattern of the heparan ...
- Cdc73 Subunit of Paf1 Complex Contains C-terminal Ras-like Domain That Promotes Association of Paf1 Complex with Chromatin
[作者:Amrich, CG; Davis, CP; Rogal, WP; Shirra, MK; Heroux, A; Gardner, RG; Arndt, KM; VanDemark, AP,期刊:Journal of Biological Chemistry, 页码:10863-10875 , 文章类型: Article,,卷期:2012年287-14]
- The conserved Paf1 complex localizes to the coding regions of genes and facilitates multiple processes during transcription elongation, including the regulation of histone modifications. However, the mechanisms that gove...
- Crystal Structure of Inhibitor of Growth 4 (ING4) Dimerization Domain Reveals Functional Organization of ING Family of Chromatin-binding Proteins
[作者:Culurgioni, S; Munoz, IG; Moreno, A; Palacios, A; Villate, M; Palmero, I; Montoya, G; Blanco, FJ,期刊:Journal of Biological Chemistry, 页码:10876-10884 , 文章类型: Article,,卷期:2012年287-14]
- The protein ING4 binds to histone H3 trimethylated at Lys-4 (H3K4me3) through its C-terminal plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters. The structure of the plant h...
- Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation
[作者:Kwon, JY; Seo, SG; Heo, YS; Yue, SH; Cheng, JX; Lee, KW; Kim, KH,期刊:Journal of Biological Chemistry, 页码:11566-11578 , 文章类型: Article,,卷期:2012年287-14]
- Piceatannol, a natural stilbene, is an analog and a metabolite of resveratrol. Despite a well documented health benefit of resveratrol in intervention of the development of obesity, the role of piceatannol in the develop...
- Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses
[作者:Racioppi, L; Noeldner, PK; Lin, FM; Arvai, S; Means, AR,期刊:Journal of Biological Chemistry, 页码:11579-11591 , 文章类型: Article,,卷期:2012年287-14]
- Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) plays a key role in regulating food intake and energy expenditure at least in part by its actions in hypothalamic neurons. Previously, we showed that loss of CaMKK2 p...
- High-capacity Ca2+ Binding of Human Skeletal Calsequestrin
[作者:Sanchez, EJ; Lewis, KM; Danna, BR; Kang, C,期刊:Journal of Biological Chemistry, 页码:11592-11601 , 文章类型: Article,,卷期:2012年287-14]
- Calsequestrin, the major calcium storage protein in both cardiac and skeletal muscle, binds large amounts of Ca2+ in the sarcoplasmic reticulum and releases them during muscle contraction. For the first time, the crystal...
- Histone Deacetylase 6 (HDAC6) Deacetylates Survivin for Its Nuclear Export in Breast Cancer
[作者:Riolo, MT; Cooper, ZA; Holloway, MP; Cheng, Y; Bianchi, C; Yakirevich, E; Ma, L; Chin, YE; Altura, RA,期刊:Journal of Biological Chemistry, 页码:10885-10893 , 文章类型: Article,,卷期:2012年287-14]
- Survivin is an oncogenic protein that is highly expressed in breast cancer and has a dual function that is dependent on its subcellular localization. In the cytosol, survivin blocks programmed cell death by inactivating ...
- Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages
[作者:Valdearcos, M; Esquinas, E; Meana, C; Pena, L; Gil-de-Gomez, L; Balsinde, J; Balboa, MA,期刊:Journal of Biological Chemistry, 页码:10894-10904 , 文章类型: Article,,卷期:2012年287-14]
- Lipin-2 is a member of the lipin family of enzymes, which are key effectors in the biosynthesis of lipids. Mutations in the humanlipin-2 gene are associated with inflammatory-based disorders; however, the role of lipin-2...
- Androgen Receptor Exon 1 Mutation Causes Androgen Insensitivity by Creating Phosphorylation Site and Inhibiting Melanoma Antigen-A11 Activation of NH2- and Carboxyl-terminal Interaction-dependent Transactivation
[作者:Lagarde, WH; Blackwelder, AJ; Minges, JT; Hnat, AT; French, FS; Wilson, EM,期刊:Journal of Biological Chemistry, 页码:10905-10915 , 文章类型: Article,,卷期:2012年287-14]
- Naturally occurring germ line mutations in the X-linked human androgen receptor (AR) gene cause incomplete masculinization of the external genitalia by disrupting AR function in males with androgen insensitivity syndrome...
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