- Seminal Plasma Accelerates Semen-derived Enhancer of Viral Infection (SEVI) Fibril Formation by the Prostatic Acid Phosphatase (PAP(248-286)) Peptide
[作者：Olsen, JS; DiMaio, JTM; Doran, TM; Brown, C; Nilsson, BL; Dewhurst, S,期刊：Journal of Biological Chemistry, 页码：11842-11849 , 文章类型： Article，,卷期：2012年287-15]
- Amyloid fibrils contained in semen, known as SEVI, or semen-derived enhancer of viral infection, have been shown to increase the infectivity of HIV dramatically. However, previous work with these fibrils has suggested th...
- Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling
[作者：Zhang, WJ; Mendoza, MC; Pei, XL; Ilter, D; Mahoney, SJ; Zhang, YM; Ma, DL; Blenis, J; Wang, Y,期刊：Journal of Biological Chemistry, 页码：11850-11858 , 文章类型： Article，,卷期：2012年287-15]
- The acquisition of an invasive phenotype is a critical turning point for malignant tumor cells. CMTM8, a potential tumor suppressor, is frequently down-regulated in solid tumors, and its overexpression induces tumor cell...
- Constitutive Expression of Inter-alpha-inhibitor (I alpha I) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex
[作者：Zhang, SZ; He, H; Day, AJ; Tseng, SCG,期刊：Journal of Biological Chemistry, 页码：12433-12444 , 文章类型： Article，,卷期：2012年287-15]
- Recently, we reported HC-HA, a covalent complex formed between heavy chains (HCs) of inter-alpha -inhibitor (I alpha I) and hyaluronan (HA) by the catalytic action of tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6)...
- ATM Protein Physically and Functionally Interacts with Proliferating Cell Nuclear Antigen to Regulate DNA Synthesis
[作者：Gamper, AM; Choi, S; Matsumoto, Y; Banerjee, D; Tomkinson, AE; Bakkenist, CJ,期刊：Journal of Biological Chemistry, 页码：12445-12454 , 文章类型： Article，,卷期：2012年287-15]
- Ataxia telangiectasia (A-T) is a pleiotropic disease, with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in A-T mutated (ATM), a gene encoding a protein kinase critical for...
- Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis
[作者：Young, MM; Takahashi, Y; Khan, O; Park, S; Hori, T; Yun, J; Sharma, AK; Amin, S; Hu, CD; Zhang, JK; Kester, M; Wang, HG,期刊：Journal of Biological Chemistry, 页码：12455-12468 , 文章类型： Article，,卷期：2012年287-15]
- Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress. However, the functional relationship between these two processes remains far from clear. Here, w...
- Microtubules Regulate Hypoxia-inducible Factor-1 alpha Protein Trafficking and Activity IMPLICATIONS FOR TAXANE THERAPY
[作者：Carbonaro, M; Escuin, D; O'Brate, A; Thadani-Mulero, M; Giannakakou, P,期刊：Journal of Biological Chemistry, 页码：11859-11869 , 文章类型： Article，,卷期：2012年287-15]
- Disruption of the microtubule cytoskeleton impairs tumor angiogenesis by inhibiting the hypoxia-inducible factor (HIF1 alpha) pathway. However, the signaling cascade linking microtubule disruption to HIF-1 alpha inactiva...
- The Kv7.2/Kv7.3 Heterotetramer Assembles with a Random Subunit Arrangement
[作者：Stewart, AP; Gomez-Posada, JC; McGeorge, J; Rouhani, MJ; Villarroel, A; Murrell-Lagnado, RD; Edwardson, JM,期刊：Journal of Biological Chemistry, 页码：11870-11877 , 文章类型： Article，,卷期：2012年287-15]
- Voltage-gated K+ channels composed of Kv7.2 and Kv7.3 are the predominant contributors to the M-current, which plays a key role in controlling neuronal activity. Various lines of evidence have indicated that Kv7.2 and Kv...
- Rac1 Protein Regulates Glycogen Phosphorylase Activation and Controls Interleukin (IL)-2-dependent T Cell Proliferation
[作者：Arrizabalaga, O; Lacerda, HM; Zubiaga, AM; Zugaza, JL,期刊：Journal of Biological Chemistry, 页码：11878-11890 , 文章类型： Article，,卷期：2012年287-15]
- Small GTPases of the Rho family have been implicated in important cellular processes such as cell migration and adhesion, protein secretion, and/or gene transcription. In the lymphoid system, these GTPases participate in...
- Phosphorylation of ORC2 Protein Dissociates Origin Recognition Complex from Chromatin and Replication Origins
[作者：Lee, KY; Bang, SW; Yoon, SW; Lee, SH; Yoon, JB; Hwang, DS,期刊：Journal of Biological Chemistry, 页码：11891-11898 , 文章类型： Article，,卷期：2012年287-15]
- During the late M to the G1 phase of the cell cycle, the origin recognition complex (ORC) binds to the replication origin, leading to the assembly of the prereplicative complex for subsequent initiation of eukaryotic chr...
- The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase delta
[作者：Kamath-Loeb, AS; Shen, JC; Schmitt, MW; Loeb, LA,期刊：Journal of Biological Chemistry, 页码：12480-12490 , 文章类型： Article，,卷期：2012年287-15]
- DNA Polymerase delta (Pol delta) and the Werner syndrome protein, WRN, are involved in maintaining cellular genomic stability. Pol delta synthesizes the lagging strand during replication of genomic DNA and also functions...
- Cross-talk between Integrin alpha 6 beta 4 and Insulin-like Growth Factor-1 Receptor (IGF1R) through Direct alpha 6 beta 4 Binding to IGF1 and Subsequent alpha 6 beta 4-IGF1-IGF1R Ternary Complex Formation in Anchorage-independent Conditions
[作者：Fujita, M; Ieguchi, K; Davari, P; Yamaji, S; Taniguchi, Y; Sekiguchi, K; Takada, YK; Takada, Y,期刊：Journal of Biological Chemistry, 页码：12491-12500 , 文章类型： Article，,卷期：2012年287-15]
- Integrin alpha v beta 3 plays a role in insulin-like growth factor-1 (IGF1) signaling (integrin-IGF1 receptor (IGF1R) cross-talk). The specifics of the cross-talk are, however, unclear. In a current model, "ligand occupa...
- Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling
[作者：Liu, L; Cao, ZY; Chen, J; Li, R; Cao, YH; Zhu, CL; Wu, KL; Wu, JG; Liu, F; Zhu, Y,期刊：Journal of Biological Chemistry, 页码：11899-11910 , 文章类型： Article，,卷期：2012年287-15]
- We previously reported that IL-27, which belongs to the IL-12 family of cytokines, is elevated in the serum of patients infected with influenza A virus (IAV). Here, we show that the expression of IL-27 was significantly ...
- Engineering Mammalian Mucin-type O-Glycosylation in Plants
[作者：Yang, Z; Drew, DP; Jorgensen, B; Mandel, U; Bach, SS; Ulvskov, P; Levery, SB; Bennett, EP; Clausen, H; Petersen, BL,期刊：Journal of Biological Chemistry, 页码：11911-11923 , 文章类型： Article，,卷期：2012年287-15]
- Mucin-type O-glycosylation is an important post-translational modification that confers a variety of biological properties and functions to proteins. This post-translational modification has a particularly complex and di...
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