- The Transcription Factor Erg Controls Endothelial Cell Quiescence by Repressing Activity of Nuclear Factor (NF)-kappa B p65
[作者:Dryden, NH; Sperone, A; Martin-Almedina, S; Hannah, RL; Birdsey, GM; Khan, ST; Layhadi, JA; Mason, JC; Haskard, DO; Gottgens, B; Randi, AM,期刊:Journal of Biological Chemistry, 页码:12331-12342 , 文章类型: Article,,卷期:2012年287-15]
- The interaction of transcription factors with specific DNA sequences is critical for activation of gene expression programs. In endothelial cells (EC), the transcription factor NF-kappa B is important in the switch from ...
- Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair
[作者:Dunlop, MH; Dray, E; Zhao, WX; Filippo, JS; Tsai, MS; Leung, SG; Schild, D; Wiese, C; Sung, P,期刊:Journal of Biological Chemistry, 页码:12343-12347 , 文章类型: Article,,卷期:2012年287-15]
- Homologous recombination catalyzed by the RAD51 recombinase is essential for maintaining genome integrity upon the induction of DNA double strand breaks and other DNA lesions. By enhancing the recombinase activity of RAD...
- Distinct Control of MyD88 Adapter-dependent and Akt Kinase-regulated Responses by the Interleukin (IL)-1RI Co-receptor, TILRR
[作者:Zhang, X; Pino, GM; Shephard, F; Kiss-Toth, E; Qwarnstrom, EE,期刊:Journal of Biological Chemistry, 页码:12348-12352 , 文章类型: Article,,卷期:2012年287-15]
- Inflammatory responses are controlled through members of the interleukin-1 receptor (IL-1R)/Toll-like receptor superfamily. Our earlier work demonstrates that the IL-1 receptor type 1 (IL-1RI) co-receptor, Toll-like and ...
- Susceptibility of beta 1 Na+-K+ Pump Subunit to Glutathionylation and Oxidative Inhibition Depends on Conformational State of Pump
[作者:Liu, CC; Garcia, A; Mahmmoud, YA; Hamilton, EJ; Galougahi, KK; Fry, NAS; Figtree, GA; Cornelius, F; Clarke, RJ; Rasmussen, HH,期刊:Journal of Biological Chemistry, 页码:12353-12364 , 文章类型: Article,,卷期:2012年287-15]
- Glutathionylation of cysteine 46 of the beta 1 subunit of the Na+-K+ pump causes pump inhibition. However, the crystal structure, known in a state analogous to an E2.2K(+)center dot P-i configuration, indicates that the ...
- Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells
[作者:Noguchi, S; Mori, T; Otsuka, Y; Yamada, N; Yasui, Y; Iwasaki, J; Kumazaki, M; Maruo, K; Akao, Y,期刊:Journal of Biological Chemistry, 页码:11769-11777 , 文章类型: Article,,卷期:2012年287-15]
- MicroRNAs regulate gene expression by repressing translation or directing sequence-specific degradation of their complementary mRNA. We recently reported that miR-203 is down-regulated, and its exogenous expression inhib...
- Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors
[作者:Wang, HC; Kunz, S; Chen, G; Seebeck, T; Wan, YQ; Robinson, H; Martinelli, S; Ke, HM,期刊:Journal of Biological Chemistry, 页码:11788-11797 , 文章类型: Article,,卷期:2012年287-15]
- Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs...
- A Bridging [4Fe-4S] Cluster and Nucleotide Binding Are Essential for Function of the Cfd1-Nbp35 Complex as a Scaffold in Iron-Sulfur Protein Maturation
[作者:Netz, DJA; Pierik, AJ; Stumpfig, M; Bill, E; Sharma, AK; Pallesen, LJ; Walden, WE; Lill, R,期刊:Journal of Biological Chemistry, 页码:12365-12378 , 文章类型: Article,,卷期:2012年287-15]
- The essential P-loop NTPases Cfd1 and Nbp35 of the cytosolic iron-sulfur (Fe-S) protein assembly machinery perform a scaffold function for Fe-S cluster synthesis. Both proteins contain a nucleotide binding motif of unkno...
- Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility
[作者:Wang, HT; Hu, Y; Tong, D; Huang, J; Gu, LY; Wu, XR; Chung, FL; Li, GM; Tang, MS,期刊:Journal of Biological Chemistry, 页码:12379-12386 , 文章类型: Article,,卷期:2012年287-15]
- Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic alpha- and gamma-hydroxy-1, N-2-cyclic propano-2'-deoxyguanosine adducts (alpha-OH-Acr-dG and gamma-...
- Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
[作者:Radic, Z; Sit, RK; Kovarik, Z; Berend, S; Garcia, E; Zhang, LM; Amitai, G; Green, C; Radic, B; Fokin, VV; Sharpless, KB; Taylor, P,期刊:Journal of Biological Chemistry, 页码:11798-11809 , 文章类型: Article,,卷期:2012年287-15]
- We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydroly...
- First and Second Generation gamma-Secretase Modulators (GSMs) Modulate Amyloid-beta (A beta) Peptide Production through Different Mechanisms
[作者:Borgegard, T; Jureus, A; Olsson, F; Rosqvist, S; Sabirsh, A; Rotticci, D; Paulsen, K; Klintenberg, R; Yan, HM; Waldman, M; Stromberg, K; Nord, J; Johansson, J; Regner, A; Parpal, S; Malinowsky, D; Radesater, AC; Li, TS; Singh, R; Eriksson, H; Lundkvist, J,期刊:Journal of Biological Chemistry, 页码:11810-11819 , 文章类型: Article,,卷期:2012年287-15]
- gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The A beta 42 peptide in particular plays a pivotal role in Alzh...
- Polarity and Bypass of DNA Heterology during Branch Migration of Holliday Junctions by Human RAD54, BLM, and RECQ1 Proteins
[作者:Mazina, OM; Rossi, MJ; Deakyne, JS; Huang, F; Mazin, AV,期刊:Journal of Biological Chemistry, 页码:11820-11832 , 文章类型: Article,,卷期:2012年287-15]
- Several proteins have been shown to catalyze branch migration (BM) of the Holliday junction, a key intermediate in DNA repair and recombination. Here, using joint molecules made by human RAD51 or Escherichia coli RecA, w...
- Endotoxin Priming of Neutrophils Requires Endocytosis and NADPH Oxidase-dependent Endosomal Reactive Oxygen Species
[作者:Lamb, FS; Hook, JS; Hilkin, BM; Huber, JN; Volk, APD; Moreland, JG,期刊:Journal of Biological Chemistry, 页码:12395-12404 , 文章类型: Article,,卷期:2012年287-15]
- NADPH oxidase 2 (Nox2)-generated reactive oxygen species (ROS) are critical for neutrophil (polymorphonuclear leukocyte (PMN)) microbicidal function. Nox2 also plays a role in intracellular signaling, but the site of oxi...
- Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD(+) Synthase
[作者:Zhang, T; Berrocal, JG; Yao, J; DuMond, ME; Krishnakumar, R; Ruhl, DD; Ryu, KW; Gamble, MJ; Kraus, WL,期刊:Journal of Biological Chemistry, 页码:12405-12416 , 文章类型: Article,,卷期:2012年287-15]
- NMNAT-1 and PARP-1, two key enzymes in the NAD(+) metabolic pathway, localize to the nucleus where integration of their enzymatic activities has the potential to control a variety of nuclear processes. Using a variety of...
- CtBP-interacting BTB Zinc Finger Protein (CIBZ) Promotes Proliferation and G1/S Transition in Embryonic Stem Cells via Nanog
[作者:Nishii, T; Oikawa, Y; Ishida, Y; Kawaichi, M; Matsuda, E,期刊:Journal of Biological Chemistry, 页码:12417-12424 , 文章类型: Article,,卷期:2012年287-15]
- Mouse embryonic stem cells (ESCs) require transcriptional regulation to ensure rapid proliferation that allows for self-renewal. However, the molecular mechanism by which transcriptional factors regulate this rapid proli...
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