- Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-beta 1
[作者:Kim, SI; Na, HJ; Ding, Y; Wang, ZB; Lee, SJ; Choi, ME,期刊:Journal of Biological Chemistry, 页码:11677-11688 , 文章类型: Article,,卷期:2012年287-15]
- Autophagy is a highly conserved cellular process regulating turnover of cytoplasmic proteins via a lysosome-dependent pathway. Here we show that kidneys from mice deficient in autophagic protein Beclin 1 exhibited profib...
- Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins
[作者:Behal, RH; Miller, MS; Qin, HM; Lucker, BF; Jones, A; Cole, DG,期刊:Journal of Biological Chemistry, 页码:11689-11703 , 文章类型: Article,,卷期:2012年287-15]
- Chlamydomonas reinhardtii intraflagellar transport (IFT) particles can be biochemically resolved into two smaller assemblies, complexes A and B, that contain up to six and 15 protein subunits, respectively. We provide he...
- Neural Crest Deletion of Dlx3 Leads to Major Dentin Defects through Down-regulation of Dspp
[作者:Duverger, O; Zah, A; Isaac, J; Sun, HW; Bartels, AK; Lian, JB; Berdal, A; Hwang, J; Morasso, MI,期刊:Journal of Biological Chemistry, 页码:12230-12240 , 文章类型: Article,,卷期:2012年287-15]
- During development, Dlx3 is expressed in ectodermal appendages such as hair and teeth. Thus far, the evidence that Dlx3 plays a crucial role in tooth development comes from reports showing that autosomal dominant mutatio...
- Noggin Is Novel Inducer of Mesenchymal Stem Cell Adipogenesis IMPLICATIONS FOR BONE HEALTH AND OBESITY
[作者:Sawant, A; Chanda, D; Isayeva, T; Tsuladze, G; Garvey, WT; Ponnazhagan, S,期刊:Journal of Biological Chemistry, 页码:12241-12249 , 文章类型: Article,,卷期:2012年287-15]
- Noggin is a glycosylated-secreted protein known so far for its inhibitory effects on bone morphogenetic protein (BMP) signaling by sequestering the BMP ligand. We report here for the first time a novel mechanism by which...
- Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway
[作者:De Bock, M; Wang, N; Bol, M; Decrock, E; Ponsaerts, R; Bultynck, G; Dupont, G; Leybaert, L,期刊:Journal of Biological Chemistry, 页码:12250-12266 , 文章类型: Article,,卷期:2012年287-15]
- Many cellular functions are driven by changes in the intracellular Ca2+ concentration ([Ca2+](i)) that are highly organized in time and space. Ca2+ oscillations are particularly important in this respect and are based on...
- The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule
[作者:Liu, YC; Chen, ZJ; Burrows, SR; Purcell, AW; McCluskey, J; Rossjohn, J; Gras, S,期刊:Journal of Biological Chemistry, 页码:12267-12276 , 文章类型: Article,,卷期:2012年287-15]
- Although the major histocompatibility complex class I (MHC-I) molecules typically bind short peptide (p) fragments (8-10 amino acids in length), longer, "bulged" peptides are often be presented by MHC-I. Such bulged pMHC...
- RED, a Spindle Pole-associated Protein, Is Required for Kinetochore Localization of MAD1, Mitotic Progression, and Activation of the Spindle Assembly Checkpoint
[作者:Yeh, PC; Yeh, CC; Chen, YC; Juang, YL,期刊:Journal of Biological Chemistry, 页码:11704-11716 , 文章类型: Article,,卷期:2012年287-15]
- The spindle assembly checkpoint (SAC) is essential for ensuring the proper attachment of kinetochores to the spindle and, thus, the precise separation of paired sister chromatids during mitosis. The SAC proteins are recr...
- H2O2-triggered Retrograde Signaling from Chloroplasts to Nucleus Plays Specific Role in Response to Stress
[作者:Maruta, T; Noshi, M; Tanouchi, A; Tamoi, M; Yabuta, Y; Yoshimura, K; Ishikawa, T; Shigeoka, S,期刊:Journal of Biological Chemistry, 页码:11717-11729 , 文章类型: Article,,卷期:2012年287-15]
- Recent findings have suggested that reactive oxygen species (ROS) are important signaling molecules for regulating plant responses to abiotic and biotic stress and that there exist source- and kind-specific pathways for ...
- Wnt/beta-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells
[作者:Konsavage, WM; Kyler, SL; Rennoll, SA; Jin, G; Yochum, GS,期刊:Journal of Biological Chemistry, 页码:11730-11739 , 文章类型: Article,,卷期:2012年287-15]
- Mutations in the Wnt/beta-catenin pathway occur in most colorectal cancers (CRCs), and these mutations lead to increased nuclear accumulation of the beta-catenin transcriptional co-activator. In the nucleus, beta-catenin...
- Herpes Simplex Virus ICP27 Protein Directly Interacts with the Nuclear Pore Complex through Nup62, Inhibiting Host Nucleocytoplasmic Transport Pathways
[作者:Malik, P; Tabarraei, A; Kehlenbach, RH; Korfali, N; Iwasawa, R; Graham, SV; Schirmer, EC,期刊:Journal of Biological Chemistry, 页码:12277-12292 , 文章类型: Article,,卷期:2012年287-15]
- The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners, inc...
- New Tricks of an Old Pattern STRUCTURAL VERSATILITY OF SCORPION TOXINS WITH COMMON CYSTEINE SPACING
[作者:Saucedo, AL; Flores-Solis, D; de la Vega, RCR; Ramirez-Cordero, B; Hernandez-Lopez, R; Cano-Sanchez, P; Navarro, RN; Garcia-Valdes, J; Coronas-Valderrama, F; de Roodt, A; Brieba, LG; Possani, LD; del Rio-Portilla, F,期刊:Journal of Biological Chemistry, 页码:12321-12330 , 文章类型: Article,,卷期:2012年287-15]
- Scorpion venoms are a rich source of K+ channel-blocking peptides. For the most part, they are structurally related small disulfide-rich proteins containing a conserved pattern of six cysteines that is assumed to dictate...
- Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria
[作者:Xu, YB; Moeller, A; Jun, SY; Le, M; Yoon, BY; Kim, JS; Lee, K; Ha, NC,期刊:Journal of Biological Chemistry, 页码:11740-11750 , 文章类型: Article,,卷期:2012年287-15]
- Gram-negative bacteria are capable of expelling diverse xenobiotic substances from within the cell by use of three-component efflux pumps in which the energy-activated inner membrane transporter is connected to the outer...
- alpha-Catenin Inhibits beta-Catenin-T-cellFactor/Lymphoid Enhancing Factor Transcriptional Activity and Collagen Type II Expression in Articular Chondrocytes through Formation of Gli3R.alpha-Catenin.beta-Catenin Ternary Complex
[作者:Rhee, J; Ryu, JH; Kim, JH; Chun, CH; Chun, JS,期刊:Journal of Biological Chemistry, 页码:11751-11760 , 文章类型: Article,,卷期:2012年287-15]
- Chondrocytes, a unique cell type in cartilage tissue, are responsible for the regulation of anabolic and catabolic homeostasis in cartilage-specific extracellular matrix synthesis. Activation of Wnt/beta-catenin signalin...
- p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy
[作者:Mei, S; Gu, HH; Ward, A; Yang, XF; Guo, HL; He, K; Liu, ZQ; Cao, WH,期刊:Journal of Biological Chemistry, 页码:11761-11768 , 文章类型: Article,,卷期:2012年287-15]
- p38 MAPK has been strongly implicated in the development of atherosclerosis, but its role in cholesterol ester accumulation in macrophages and formation of foam cells, an early step in the development of atherosclerosis,...
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