- Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer
[作者:Guttenplan, JB; Kosinska, W; Zhao, ZL; Chen, KM; Aliaga, C; DelTondo, J; Cooper, T; Sun, YW; Zhang, SM; Jiang, K; Bruggeman, R; Sharma, AK; Amin, S; Ahn, K; El-Bayoumy, K,期刊:International Journal of Cancer, 页码:2783-2790 , 文章类型: Article,,卷期:2012年130-12]
- Cancer of the oral cavity is a serious disease, affecting about 30,000 individuals in US annually. There are several animal models of oral cancer, but each has certain disadvantages. As a new model, we investigated wheth...
- Urinary acylcarnitines are altered in human kidney cancer
[作者:Ganti, S; Taylor, SL; Kim, K; Hoppel, CL; Guo, LN; Yang, J; Evans, C; Weiss, RH,期刊:International Journal of Cancer, 页码:2791-2800 , 文章类型: Article,,卷期:2012年130-12]
- Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to novel approaches to diagnosis is needed. Our laboratory has ...
- ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma
[作者:Spangler, B; Kappelmann, M; Schittek, B; Meierjohann, S; Vardimon, L; Bosserhoff, AK; Kuphal, S,期刊:International Journal of Cancer, 页码:2801-2811 , 文章类型: Article,,卷期:2012年130-12]
- Recently, we discovered that the loss of E-cadherin induces c-Jun protein expression, which is a member of the AP-1 transcription factor family and a key player in the processes of cell proliferation and tumor developmen...
- Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells
[作者:Tsui, KH; Chung, LC; Feng, TH; Chang, PL; Juang, HH,期刊:International Journal of Cancer, 页码:2812-2823 , 文章类型: Article,,卷期:2012年130-12]
- Luteolin is a polyphenolic flavone and has antitumor activity for many cancers. The prostate-derived Ets factor (PDEF), a novel epithelium-specific Ets transcription factor, acts as an androgen-independent transcriptiona...
- P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma
[作者:Brambilla, D; Zamboni, S; Federici, C; Lugini, L; Lozupone, F; De Milito, A; Cecchetti, S; Cianfriglia, M; Fais, S,期刊:International Journal of Cancer, 页码:2824-2834 , 文章类型: Article,,卷期:2012年130-12]
- Overexpression of the mdr1 gene encoding P-glycoprotein (Pgp) exerts a major role in reducing the effectiveness of cytotoxic therapy in osteosarcoma. The interaction between actin and Pgp has been shown to be instrumenta...
- Carbidopa abrogates L-dopa decarboxylase coactivation of the androgen receptor and delays prostate tumor progression
[作者:Wafa, LA; Cheng, HL; Plaa, N; Ghaidi, F; Fukumoto, T; Fazli, L; Gleave, ME; Cox, ME; Rennie, PS,期刊:International Journal of Cancer, 页码:2835-2844 , 文章类型: Article,,卷期:2012年130-12]
- The androgen receptor (AR) plays a central role in prostate cancer progression to the castration-resistant (CR) lethal state. L-Dopa decarboxylase (DDC) is an AR coactivator that increases in expression with disease prog...
- High prevalence and breast cancer predisposing role of the BLM c.1642 C > T (Q548X) mutation in Russia
[作者:Sokolenko, AP; Iyevleva, AG; Preobrazhenskaya, EV; Mitiushkina, NV; Abysheva, SN; Suspitsin, EN; Kuligina, ES; Gorodnova, TV; Pfeifer, W; Togo, AV; Turkevich, EA; Ivantsov, AO; Voskresenskiy, DV; Dolmatov, GD; Bit-Sava, EM; Matsko, DE; Semiglazov, VF; Fichtner, I; Larionov, AA; Kuznetsov, SG; Antoniou, AC; Imyanitov, EN,期刊:International Journal of Cancer, 页码:2867-2873 , 文章类型: Article,,卷期:2012年130-12]
- The BLM gene belongs to the RecQ helicase family and has been implicated in the maintenance of genomic stability. Its homozygous germline inactivation causes Bloom syndrome, a severe genetic disorder characterized by gro...
- Different DNA damage and cell cycle checkpoint control in low- and high-risk human papillomavirus infections of the vulva
[作者:Santegoets, LAM; van Baars, R; Terlou, A; Heijmans-Antonissen, C; Swagemakers, SMA; van der Spek, PJ; Ewing, PC; van Beurden, M; van der Meijden, WI; Helmerhorst, TJM; Blok, LJ,期刊:International Journal of Cancer, 页码:2874-2885 , 文章类型: Article,,卷期:2012年130-12]
- Human papillomavirus (HPV) infections may result in benign hyperplasia, caused by low-risk HPV types, or (pre)malignant lesions caused by high-risk HPV types. The molecular basis of this difference in malignant potential...
- Calreticulin promotes tumor lymphocyte infiltration and enhances the antitumor effects of immunotherapy by up-regulating the endothelial expression of adhesion molecules
[作者:Wang, HT; Lee, HI; Guo, JH; Chen, SH; Liao, ZK; Huang, KW; Torng, PL; Hwang, LH,期刊:International Journal of Cancer, 页码:2892-2902 , 文章类型: Article,,卷期:2012年130-12]
- Tumor-induced angiogenesis has been shown to suppress immune responses. One mechanism is to suppress leukocyteendothelial cell interaction by down-regulating the expression of adhesion molecules, such as intercellular ad...
- Dermatopontin: A potential predictor for metastasis of human oral cancer
[作者:Yamatoji, M; Kasamatsu, A; Kouzu, Y; Koike, H; Sakamoto, Y; Ogawara, K; Shiiba, M; Tanzawa, H; Uzawa, K,期刊:International Journal of Cancer, 页码:2903-2911 , 文章类型: Article,,卷期:2012年130-12]
- Dermatopontin (DPT), a component of the extracellular matrix (ECM), is involved in promotion of cellular adhesion and ECM assembly activities. However, the role of DPT in the pathogenesis of carcinoma is unclear. We eval...
- Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancer
[作者:Toiyama, Y; Yasuda, H; Saigusa, S; Matushita, K; Fujikawa, H; Tanaka, K; Mohri, Y; Inoue, Y; Goel, A; Kusunoki, M,期刊:International Journal of Cancer, 页码:2912-2921 , 文章类型: Article,,卷期:2012年130-12]
- Epithelialmesenchymal transition (EMT) promotes and facilitates migration and invasion of epithelial tumor cells. EMT is induced by factors such as hepatocyte growth factor (HGF). This study aimed to establish whether th...
- Serum endostatin levels correlate with enhanced extracellular matrix degradation and poor patients' prognosis in bladder cancer
[作者:Szarvas, T; Laszlo, V; vom Dorp, F; Reis, H; Szendroi, A; Romics, I; Tilki, D; Rubben, H; Ergun, S,期刊:International Journal of Cancer, 页码:2922-2929 , 文章类型: Article,,卷期:2012年130-12]
- Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis i...
- Breast cancer incidence trends in Norway-explained by hormone therapy or mammographic screening?
[作者:Hofvind, S; Sakshaug, S; Ursin, G; Graff-Iversen, S,期刊:International Journal of Cancer, 页码:2930-2938 , 文章类型: Article,,卷期:2012年130-12]
- A decline in breast cancer incidence has been observed in several countries after 2002. Reduced use of menopausal hormonal therapy (HT), as a consequence of the publication of results from the Women's Health Initiative, ...
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