- Fibronectin Extra Domain-A Promotes Hepatic Stellate Cell Motility but Not Differentiation Into Myofibroblasts
[作者：Olsen, AL; Sackey, BK; Marcinkiewicz, C; Boettiger, D; Wells, RG,期刊：Gastroenterology, 页码：928-U405 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Myofibroblasts are the primary cell type involved in physiologic wound healing and its pathologic counterpart, fibrosis. Cellular fibronectin that contains the alternatively spliced extra domain A (EII...
- Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues
[作者：Hernandez-Gea, V; Ghiassi-Nejad, Z; Rozenfeld, R; Gordon, R; Fiel, MI; Yue, ZY; Czaja, MJ; Friedman, SL,期刊：Gastroenterology, 页码：938-946 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid droplets. When hepatocytes undergo autophagy, intracellular l...
- Diverse Functional Properties of Wilson Disease ATP7B Variants
[作者：Huster, D; Kuhne, A; Bhattacharjee, A; Raines, L; Jantsch, V; Noe, J; Schirrmeister, W; Sommerer, I; Sabri, O; Berr, F; Mossner, J; Stieger, B; Caca, K; Lutsenko, S,期刊：Gastroenterology, 页码：947-U429 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Wilson disease is a severe disorder of copper metabolism caused by mutations in ATP7B, which encodes a copper-transporting adenosine triphosphatase. The disease presents with a variable phenotype that ...
- Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival
[作者：Roessler, S; Long, EL; Budhu, A; Chen, YD; Zhao, XL; Ji, JF; Walker, R; Jia, HL; Ye, QH; Qin, LX; Tang, ZY; He, P; Hunter, KW; Thorgeirsson, SS; Meltzer, PS; Wang, XW,期刊：Gastroenterology, 页码：957-U451 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as...
- Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice
[作者：Dill, MT; Rothweiler, S; Djonov, V; Hlushchuk, R; Tornillo, L; Terracciano, L; Meili-Butz, S; Radtke, F; Heim, MH; Semela, D,期刊：Gastroenterology, 页码：967-U464 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has ...
- HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons
[作者：Thomas, E; Gonzalez, VD; Li, QS; Modi, AA; Chen, WP; Noureddin, M; Rotman, Y; Liang, TJ,期刊：Gastroenterology, 页码：978-988 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Polymorphisms in the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection. Little is known about the function of...
- Estrogen Receptor alpha Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4 alpha
[作者：Wang, SH; Yeh, SH; Lin, WH; Yeh, KH; Yuan, Q; Xia, NS; Chen, DS; Chen, PJ,期刊：Gastroenterology, 页码：989-U489 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Women with hepatitis B virus (HBV) infection usually have lower viral loads than men, reducing their risk of liver cancer. There are 2 androgen-responsive elements in the HBV enhancer I that contribute...
- Pancreas-Specific Deletion of Prox1 Affects Development and Disrupts Homeostasis of the Exocrine Pancreas
[作者：Westmoreland, JJ; Kilic, G; Sartain, C; Sirma, S; Blain, J; Rehg, J; Harvey, N; Sosa-Pineda, B,期刊：Gastroenterology, 页码：999-U506 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: The exocrine portion of the pancreas functions in digestion and preserves pancreatic homeostasis. Learning how this tissue forms during embryogenesis could improve our understanding of human pancreatic...
- CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
[作者：Saeki, K; Kanai, T; Nakano, M; Nakamura, Y; Miyata, N; Sujino, T; Yamagishi, Y; Ebinuma, H; Takaishi, H; Ono, Y; Takeda, K; Hozawa, S; Yoshimura, A; Hibi, T,期刊：Gastroenterology, 页码：1010-U526 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Acute pancreatitis is a common inflammatory disease mediated by damage to acinar cells and subsequent pancreatic inflammation with recruitment of leukocytes. We investigated the pathologic roles of inn...
- Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors
[作者：Andersen, JB; Spee, B; Blechacz, BR; Avital, I; Komuta, M; Barbour, A; Conner, EA; Gillen, MC; Roskams, T; Roberts, LR; Factor, VM; Thorgeirsson, SS,期刊：Gastroenterology, 页码：1021-U552 , 文章类型： Article，,卷期：2012年142-4]
- BACKGROUND & AIMS: Cholangiocarcinoma is a heterogeneous disease with a poor outcome that accounts for 5% - 10% of primary liver cancers. We characterized its genomic and genetic features and associated these with patien...
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