- Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV
[作者:Chen, HL; Lin, LH; Hu, FC; Lee, JT; Lin, WT; Yang, YJ; Huang, FC; Wu, SF; Chen, SCC; Wen, WH; Chu, CH; Ni, YH; Hsu, HY; Tsai, PL; Chiang, CL; Shyu, MK; Lee, PI; Chang, FY; Chang, MH,期刊:Gastroenterology, 页码:773-U186 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant women and administering hepatitis B i...
- Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure
[作者:Kribben, A; Gerken, G; Haag, S; Herget-Rosenthal, S; Treichel, U; Betz, C; Sarrazin, C; Hoste, E; Van Vlierberghe, H; Escorsell, A; Hafer, C; Schreiner, O; Galle, PR; Mancini, E; Caraceni, P; Karvellas, CJ; Salmhofer, H; Knotek, M; Gines, P; Kozik-Jaromin, J; Rifai, K,期刊:Gastroenterology, 页码:782-U197 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Fractionated plasma separation and adsorption (FPSA) is an extracorporeal procedure that supports liver function by removing endogenous toxins that cause complications from acute-on-chronic liver failu...
- Effect of IL28B Genotype on Early Viral Kinetics During Interferon-Free Treatment of Patients With Chronic Hepatitis C
[作者:Chu, TW; Kulkarni, R; Gane, EJ; Roberts, SK; Stedman, C; Angus, PW; Ritchie, B; Lu, XY; Ipe, D; Lopatin, U; Germer, S; Iglesias, VA; Elston, R; Smith, PF; Shulman, NS,期刊:Gastroenterology, 页码:790-795 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Although interleukin 28B (interferon, lambda 3) (IL28B) genotype affects the response of patients with chronic hepatitis C to peginterferon and ribavirin, little is known regarding its effect on respon...
- Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals
[作者:Canto, MI; Hruban, RH; Fishman, EK; Kamel, IR; Schulick, R; Zhang, Z; Topazian, M; Takahashi, N; Fletcher, J; Petersen, G; Klein, AP; Axilbund, J; Griffin, C; Syngal, S; Saltzman, JR; Mortele, KJ; Lee, J; Tamm, E; Vikram, R; Bhosale, P; Margolis, D; Farrell, J; Goggins, M,期刊:Gastroenterology, 页码:796-804 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neopla...
- Endoscopic Ultrasound-Guided Transmural and Percutaneous Transhepatic Gallbladder Drainage Are Comparable for Acute Cholecystitis
[作者:Jang, JW; Lee, SS; Song, TJ; Hyun, YS; Park, DH; Seo, DW; Lee, SK; Kim, MH; Yun, SC,期刊:Gastroenterology, 页码:805-811 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Endoscopic ultrasound-guided transmural gallbladder drainage (EUS-GBD) is an alternative to percutaneous transhepatic gallbladder drainage (PTGBD) for patients with acute, high-risk, or advanced-stage ...
- RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the beta-Catenin Destruction Complex
[作者:Deng, YZ; Yao, F; Li, JJ; Mao, ZF; Hu, PT; Long, LY; Li, G; Ji, XD; Shi, S; Guan, DX; Feng, YY; Cui, L; Li, DS; Liu, Y; Du, X; Guo, MZ; Xu, LY; Li, EM; Wang, HY; Xie, D,期刊:Gastroenterology, 页码:812-U246 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Dysregulation of Wnt signaling has been involved in gastric tumorigenesis by mechanisms that are not fully understood. The receptor for activated protein kinase C (RACK1, GNB2L1) is involved in develop...
- Folic Acid Increases Global DNA Methylation and Reduces Inflammation to Prevent Helicobacter-Associated Gastric Cancer in Mice
[作者:Gonda, TA; Kim, YI; Salas, MC; Gamble, MV; Shibata, W; Muthupalani, S; Sohn, KJ; Abrams, JA; Fox, JG; Wang, TC; Tycko, B,期刊:Gastroenterology, 页码:824-U263 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied, and the mechanisms by which FA exerts chemopreventive effec...
- Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats
[作者:Rasmussen, BA; Breen, DM; Luo, P; Cheung, GWC; Yang, CS; Sun, BY; Kokorovic, A; Rong, WF; Lam, TKT,期刊:Gastroenterology, 页码:834-U276 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: The duodenum senses nutrients to maintain energy and glucose homeostasis, but little is known about the signaling and neuronal mechanisms involved. We tested whether duodenal activation of adenosine 3'...
- Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity
[作者:Hoffman, JM; Tyler, K; MacEachern, SJ; Balemba, OB; Johnson, AC; Brooks, EM; Zhao, H; Swain, GM; Moses, PL; Galligan, JJ; Sharkey, KA; Greenwood-Van Meerveld, B; Mawe, GM,期刊:Gastroenterology, 页码:844-U291 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT4R) agonists promote gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have restricted their availability. We tested the hypo...
- Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis
[作者:Galandiuk, S; Rodriguez-Justo, M; Jeffery, R; Nicholson, AM; Cheng, Y; Oukrif, D; Elia, G; Leedham, SJ; McDonald, SAC; Wright, NA; Graham, TA,期刊:Gastroenterology, 页码:855-U309 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with non-dysplastic but tumorigenic clones) might contribute to intestin...
- The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
[作者:Nishida, A; Lau, CW; Zhang, M; Andoh, A; Shi, HN; Mizoguchi, E; Mizoguchi, A,期刊:Gastroenterology, 页码:865-U321 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: T helper (Th) 17 cells produce the effector cytokine interleukin (IL)-17, along with IL-22, which stimulates colonic epithelial cells to produce a membrane-bound mucin, Muc1. Muc1 is a component of the...
- Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and beta-Catenin Activity in Colon Cancer Cells
[作者:Hinkel, I; Duluc, I; Martin, E; Guenot, D; Freund, JN; Gross, I,期刊:Gastroenterology, 页码:875-U335 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: The intestine-specific homeobox transcription factor Cdx2 is an important determinant of intestinal identity in the embryonic endoderm and regulates the balance between proliferation and differentiatio...
- Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells
[作者:Almeida, MI; Nicoloso, MS; Zeng, LZ; Ivan, C; Spizzo, R; Gafa, R; Xiao, LC; Zhang, XN; Vannini, I; Fanini, F; Fabbri, M; Lanza, G; Reis, RM; Zweidler-McKay, PA; Calin, GA,期刊:Gastroenterology, 页码:886-U355 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in thei...
- Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver
[作者:Ross, J; Gherardi, E; Mallorqui-Fernandez, N; Bocci, M; Sobkowicz, A; Rees, M; Rowe, A; Ellmerich, S; Massie, I; Soeda, J; Selden, C; Hodgson, H,期刊:Gastroenterology, 页码:897-906 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Hepatocyte growth factor/scatter factor (HGF/SF) stimulates hepatocyte DNA synthesis and protects against apoptosis; in vivo it promotes liver regeneration and reduces fibrosis. However, its therapeuti...
- Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared With Differentiated Liver Cells, Requires the BAF Complex
[作者:Kleger, A; Mahaddalkar, PU; Katz, SF; Lechel, A; Joo, JY; Loya, K; Lin, Q; Hartmann, D; Liebau, S; Kraus, JM; Cantz, T; Kestler, HA; Zaehres, H; Scholer, H; Rudolph, KL,期刊:Gastroenterology, 页码:907-917 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Ectopic expression of certain transcription factors can reprogram somatic cells to a pluripotent state. Hematopoietic and muscle stem cells can be more efficiently reprogrammed than differentiated bloo...
- Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats
[作者:Xie, GH; Wang, XD; Wang, L; Wang, L; Atkinson, RD; Kanel, GC; Gaarde, WA; DeLeve, LD,期刊:Gastroenterology, 页码:918-U392 , 文章类型: Article,,卷期:2012年142-4]
- BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated whether restoration of LSEC differentiat...
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