- Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice
[作者:Zhao, Y; Zhang, Y; Zhou, MY; Wang, SM; Hua, ZC; Zhang, JF,期刊:FEBS Letters, 页码:1306-1311 , 文章类型: Article,,卷期:2012年586-9]
- The existence of peripheral oscillators has been shown, and they are critically important for organizing the metabolism of the whole body. Here we show that mice deficient in mPer2 markedly increase circulatory levels of...
- Mechanical load-dependent cardiac ER stress in vitro and in vivo: Effects of preload and afterload
[作者:Toischer, K; Kochhauser, S; Van, PN; Leineweber, K; Hasenfuss, G; Kogler, H,期刊:FEBS Letters, 页码:1363-1369 , 文章类型: Article,,卷期:2012年586-9]
- Proteins are folded in the endoplasmic reticulum (ER). ER stress initially leads to compensatory upregulation of ER chaperones and later to apoptosis, but the contribution of biomechanical load vs. neurohumoral stress to...
- MiR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1
[作者:Wang, L; Shi, M; Hou, SX; Ding, BJ; Liu, LJ; Ji, XT; Zhang, J; Deng, YC,期刊:FEBS Letters, 页码:1312-1317 , 文章类型: Article,,卷期:2012年586-9]
- MicroRNAs (miRNAs) exhibit tumor-specific expression signatures and play crucial roles in tumorigenesis by targeting oncogenes. Here, through analyzing the miRNA-array profiles of human glioblastoma tissues and the adjac...
- Ceramide kinase deficiency improves diet-induced obesity and insulin resistance
[作者:Mitsutake, S; Date, T; Yokota, H; Sugiura, M; Kohama, T; Igarashi, Y,期刊:FEBS Letters, 页码:1300-1305 , 文章类型: Article,,卷期:2012年586-9]
- Ceramide kinase (CERK) is an enzyme that phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanie...
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