- In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
[作者:Nakatani, T; Sarraj, B; Ohnishi, M; Densmore, MJ; Taguchi, T; Goetz, R; Mohammadi, M; Lanske, B; Razzaque, MS,期刊:FASEB Journal, 页码:433-441 , 文章类型: Article,,卷期:2009年23-2]
- A major breakthrough in systemic phosphate homeostasis regulation was achieved by the demonstration of strikingly similar physical, morphological, and biochemical phenotypes of fibroblast growth factor 23 (Fgf23) and klo...
- Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci
[作者:Graham, JD; Hanson, AR; Croft, AJ; Fox, AH; Clarke, CL,期刊:FASEB Journal, 页码:546-556 , 文章类型: Article,,卷期:2009年23-2]
- The ovarian hormone progesterone is essential for normal breast development, and progesterone analogues are implicated in increasing breast cancer risk. The progesterone receptor (PR) is a transcription factor that, when...
- MARCKS silencing differentially affects human vascular smooth muscle and endothelial cell phenotypes to inhibit neointimal hyperplasia in saphenous vein
[作者:Monahan, TS; Andersen, ND; Martin, MC; Malek, JY; Shrikhande, GV; Pradhan, L; Ferran, C; LoGerfo, FW,期刊:FASEB Journal, 页码:557-564 , 文章类型: Article,,卷期:2009年23-2]
- Intimal hyperplasia (IH) limits the patency of all cardiovascular vein bypass grafts. We previously found the myristoylated alanine-rich C kinase substrate (MARCKS), a key protein kinase C (PKC) substrate, to be up-regul...
- Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc gamma RI
[作者:Bonetto, S; Spadola, L; Buchanan, AG; Jermutus, L; Lund, J,期刊:FASEB Journal, 页码:575-585 , 文章类型: Article,,卷期:2009年23-2]
- Identification of short, structured peptides able to mimic potently protein-protein interfaces remains a challenge in drug discovery. We report here the use of a naive cyclic peptide phage display library to identify pep...
- Metabolic profiling of PPAR alpha(-/-) mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
[作者:Makowski, L; Noland, RC; Koves, TR; Xing, WB; Ilkayeva, OR; Muehlbauer, MJ; Stevens, RD; Muoio, DM,期刊:FASEB Journal, 页码:586-604 , 文章类型: Article,,卷期:2009年23-2]
- Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a master transcriptional regulator of beta-oxidation and a prominent target of hypolipidemic drugs. To gain deeper insights into the systemic consequences ...
- Alkaline ceramidase 2 regulates beta 1 integrin maturation and cell adhesion
[作者:Sun, W; Hu, W; Xu, RJ; Jin, JF; Szulc, ZM; Zhang, GF; Galadari, SH; Obeid, LM; Mao, CG,期刊:FASEB Journal, 页码:656-666 , 文章类型: Article,,卷期:2009年23-2]
- The polypeptide core of the integrin beta 1 subunit (beta 1) is glycosylated sequentially in the endoplasmic reticulum and the Golgi complex to form beta 1 precursor and mature beta 1, respectively. The beta 1 precursor ...
- Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone
[作者:Bolego, C; Buccellati, C; Prada, A; Gaion, RM; Folco, G; Sala, A,期刊:FASEB Journal, 页码:605-612 , 文章类型: Article,,卷期:2009年23-2]
- We aimed at evaluating the relative contribution of cyclooxygenase (COX) -1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid...
- Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors
[作者:Sheldon, H; Andre, M; Legg, JA; Heal, P; Herbert, JM; Sainson, R; Sharma, AS; Kitajewski, JK; Heath, VL; Bicknell, R,期刊:FASEB Journal, 页码:513-522 , 文章类型: Article,,卷期:2009年23-2]
- This study aimed to further elucidate the function of Roundabout proteins in endothelium. We show that both Robo1 and Robo4 are present in human umbilical vein endothelial cells (HUVECs) and have knocked expression down ...
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