- Asymmetric synthesis and cytotoxicity of (-)-saframycin A analogues
[作者:Dong, WF; Liu, W; Yan, Z; Liao, XW; Guan, BH; Wang, N; Liu, ZZ,期刊:European Journal of Medicinal Chemistry, 页码:239-244 , 文章类型: Article,,卷期:2012年49-1]
- (-)-Saframycin A and its nineteen analogues were prepared from L-tyrosine in 24 steps, and their structures were confirmed through NMR and HRMS. The cytotoxicities of these compounds were tested against HCT-8, BEL-7402, ...
- Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors
[作者:Ha, YM; Park, YJ; Kim, JA; Park, D; Park, JY; Lee, HJ; Lee, JY; Moon, HR; Chung, HY,期刊:European Journal of Medicinal Chemistry, 页码:245-252 , 文章类型: Article,,卷期:2012年49-1]
- In continuing our search for novel tyrosinase inhibitors, a series of 5-(substituted benzylidene)thiazolidine-2,4-diones were rationally designed and synthesized, and their inhibitory effects on mushroom tyrosinase activ...
- Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents
[作者:Li, SY; Guo, CY; Sun, XQ; Li, YZ; Zhao, HL; Zhan, DM; Lan, MB; Tang, Y,期刊:European Journal of Medicinal Chemistry, 页码:271-278 , 文章类型: Article,,卷期:2012年49-1]
- 4-anilinoquinazoline and 4-anilinoquinoline scaffolds bearing a 2,2,6,6-tetramethylpiperidine-N-oxy-1(TEMPO) have been synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and A431 cell lines. Comp...
- Efficient synthesis and anti-enteroviral activity of 9-arylpurines
[作者:Aguado, L; Canela, MD; Thibaut, HJ; Priego, EM; Camarasa, MJ; Leyssen, P; Neyts, J; Perez-Perez, MJ,期刊:European Journal of Medicinal Chemistry, 页码:279-288 , 文章类型: Article,,卷期:2012年49-1]
- To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series of compounds with a dialkylamino, (alkyl)amido, or oxazolidinone substituent at the aryl ring have been synthesized, in m...
- Structure-activity relationships of novel alkylides: 3-O-Arylalkyl clarithromycin derivatives with improved antibacterial activities
[作者:Liang, JH; Li, XL; Wang, H; An, K; Wang, YY; Xu, YC; Yao, GW,期刊:European Journal of Medicinal Chemistry, 页码:289-303 , 文章类型: Article,,卷期:2012年49-1]
- A series of novel alkylides, possessing 3-O-arylallcyl group instead of 3-O-cladinose, were designed, synthesized and evaluated for in vitro antibacterial activities. The increased potency clearly ranked by the order of ...
- Synthesis and evaluation of anticancer activity of some novel 6-aryl-2-(p-sulfamylpheny1)-pyridazin-3(2H)-ones
[作者:Rathish, IG; Javed, K; Ahmad, S; Bano, S; Alam, MS; Akhter, M; Pillai, KK; Ovais, S; Samim, M,期刊:European Journal of Medicinal Chemistry, 页码:304-309 , 文章类型: Article,,卷期:2012年49-1]
- A series of novel pyridazinone derivatives bearing benzenesulfonamide moiety (2a-h) has been synthesized by the condensation of appropriate aroylacrylic acid and 4-hydrazinobenzenesulfonamide hydrochloride in ethanol. Fi...
- Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT(1)/MT(2)) and serotoninergic 5-HT(2C) dual ligands (I)
[作者:Ettaoussi, M; Sabaouni, A; Rami, M; Boutin, JA; Delagrange, P; Renard, P; Spedding, M; Caignard, DH; Berthelot, P; Yous, S,期刊:European Journal of Medicinal Chemistry, 页码:310-323 , 文章类型: Article,,卷期:2012年49-1]
- As part of our ongoing interest in developing new melatoninergic ligands bearing the same pharmacological profile as agomelatine, we focused our attention on this compound as a lead. Several chemical modifications have b...
- Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: Their anti-inflammatory and anti-nociceptive activities
[作者:Shafi, S; Alam, MM; Mulakayala, N; Mulakayala, C; Vanaja, G; Kalle, AM; Pallu, R; Alam, MS,期刊:European Journal of Medicinal Chemistry, 页码:324-333 , 文章类型: Article,,卷期:2012年49-1]
- A focused library of novel bis-heterocycles encompassing 2-mercapto benzothiazole and 1,2,3-triazoles were synthesized using click chemistry approach. The synthesized compounds have been tested for their anti-inflammator...
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