- NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression
[作者:Reynolds, N; Salmon-Divon, M; Dvinge, H; Hynes-Allen, A; Balasooriya, G; Leaford, D; Behrens, A; Bertone, P; Hendrich, B,期刊:EMBO journal, 页码:593-605 , 文章类型: Article,,卷期:2012年31-3]
- Pluripotent cells possess the ability to differentiate into any cell type. Commitment to differentiate into specific lineages requires strict control of gene expression to coordinate the downregulation of lineage inappro...
- Transcription and histone methylation changes correlate with imprint acquisition in male germ cells
[作者:Henckel, A; Chebli, K; Kota, SK; Arnaud, P; Feil, R,期刊:EMBO journal, 页码:606-615 , 文章类型: Article,,卷期:2012年31-3]
- Genomic imprinting in mammals is controlled by DNA methylation imprints that are acquired in the gametes, at essential sequence elements called 'imprinting control regions' (ICRs). What signals paternal imprint acquisiti...
- The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin
[作者:Driskell, I; Oda, H; Blanco, S; Nascimento, E; Humphreys, P; Frye, M,期刊:EMBO journal, 页码:616-629 , 文章类型: Article,,卷期:2012年31-3]
- Setd8/PR-Set7/KMT5a-dependent mono-methylation of histone H4 at lysine 20 is essential for mitosis of cultured cells; yet, the functional roles of Setd8 in complex mammalian tissues are unknown. We use skin as a model sy...
- Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions
[作者:Durieux, PF; Schiffmann, SN; d'Exaerde, AD,期刊:EMBO journal, 页码:640-653 , 文章类型: Article,,卷期:2012年31-3]
- The dorsal striatum is critically involved in a variety of motor behaviours, including regulation of motor activity, motor skill learning and motor response to psychostimulant and neuroleptic drugs, but contribution of D...
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